Combined cognitive-behavioral and time-limited alprazolam treatment of panic disorder

Hegel, Mark T.; Ravaris, C. Lewis; Ahles, Tim A.

doi:10.1016/s0005-7894(05)80282-5

Cited by 61 publications

(29 citation statements)

References 26 publications

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“…But during the subsequent 6 months, half of those who had stopped it without cognitive behavior therapy relapsed, compared with none who had stopped it with cognitive behavior therapy. Although the number of subjects in the trial was small, a comparable success rate was obtained by Hegel et al (68), who used similar cognitive behavior therapy and drug taper procedures with 25 patients with panic disorder.…”

Section: Benzodiazepine Discontinuation Trialsmentioning

confidence: 68%

“…The possibility that cognitive behavior therapy techniques might assist patients to stop benzodiazepine use PANIC DISORDER was suggested by Tyrer et al (66) in 1985 and has since been investigated in several small studies (13,(67)(68)(69)(70)(71). Three of those studies involved patients with panic disorder whose use of benzodiazepines was discontinued.…”

Section: Benzodiazepine Discontinuation Trialsmentioning

confidence: 99%

“…Simply superimposing standard monotherapy protocols, as was done in the London/Toronto trial, has been unsuccessful in achieving that goal. On the other hand, when the individual treatments have been adapted and integrated, as was done in the Peoria and Dartmouth alprazolam discontinuation trials (13,68), the results have been more promising. However, to integrate drug and behavioral therapies effectively, therapists need to make a variety of clinical decisions for which guidelines currently are lacking.…”

Section: Potential Disadvantages Of Combining Treatmentsmentioning

confidence: 99%

“…We have found that procedure to be better tolerated than more rapid taper schedules with regard to both withdrawal symptoms and patients' apprehension about drug discontinuance. In the successful benzodiazepine discontinuation studies (13,68,70), drug taper was initiated during cognitive behavior therapy, in conjunction with interoceptive exposure, and subjects were encouraged to use any emergent symptoms as they would symptoms elicited by the exposure procedures, that is, as opportunities for habituation and cognitive restructuring. It seems wise to keep any drugonly phase of combined treatment as short as possible because longer benzodiazepine use before cognitive behavior therapy has been associated with increased attrition and greater relapse after treatment (14).…”

Section: Integrated Treatment Decisionsmentioning

confidence: 99%

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Benzodiazepines and exposure-based cognitive behavior therapies for panic disorder: conclusions from combined treatment trials

Spiegel

Bruce²

1997

AJP

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Section: Benzodiazepine Discontinuation Trialsmentioning

confidence: 68%

Section: Benzodiazepine Discontinuation Trialsmentioning

confidence: 99%

Section: Potential Disadvantages Of Combining Treatmentsmentioning

confidence: 99%

Section: Integrated Treatment Decisionsmentioning

confidence: 99%

See 2 more Smart Citations

Benzodiazepines and exposure-based cognitive behavior therapies for panic disorder: conclusions from combined treatment trials

Spiegel

Bruce²

1997

AJP

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“…CBT was more effective than control conditions in the reduction of panic (d = , and as effective as antidepressants and their combination in the shorter term outcome on panic, depression, anxiety and agoraphobic avoidance. The shorter term benefits of CBT for panic disorder with or without agoraphobia appear to be sustained at 6 months, 9-15 at 12 months [16][17][18] and at 15 months. 19 …”

Section: Panic Disordermentioning

confidence: 96%

Long-term outcome of cognitive behaviour therapy clinical trials in central Scotland

Durham

Chambers²,

Power³

et al. 2005

Health Technol Assess

109

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A cognitive approach to understanding and treating anxiety

Reilly¹,

Sokol²,

Butler³

1999

Hum. Psychopharmacol. Clin. Exp.

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Combined cognitive-behavioral and time-limited alprazolam treatment of panic disorder

Cited by 61 publications

References 26 publications

Benzodiazepines and exposure-based cognitive behavior therapies for panic disorder: conclusions from combined treatment trials

Benzodiazepines and exposure-based cognitive behavior therapies for panic disorder: conclusions from combined treatment trials

Long-term outcome of cognitive behaviour therapy clinical trials in central Scotland

A cognitive approach to understanding and treating anxiety

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