Combined CML and CLL in four patients, including one with 17p deletion

Armarego, Michael; Gottlieb, David; Cooney, Julian

doi:10.1016/j.pathol.2017.12.284

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“…A group performed a study on three-way translocations by flow cytometric sorting using monoclonal antibody anti-CD19 lacked the BCR-ABL rearrangement. Their results suggested CML and CLL were from two different clones B-cell transformation occurred in a Ph-B-cell subset [57].…”

Section: Issues Of the Combination Of CML And Chronic Lymphocytic Leumentioning

confidence: 99%

Milestone Histories and Paradigmatic Genetic Discoveries of Chronic Myeloid Leukemia (CML)

Wu¹

2020

Rare Diseases

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Chronic myeloid leukemia (CML) is classified as a hematological malignant rare disease by National Organization for Rare Disease (NORD, USA) based on the estimated incidence of 1-2 cases/100,000 per year internationally. CML occurs in all ages but commonly seen in the 45-55 years group. Males are slightly more affected than females. CML is one of the oldest known diseases with new faces and one of the fastest developing diseases with many extraordinary discoveries in human history of conquering the disease. CML possesses at least Nine First findings in leukemia and cancer research and even in human medical histories: the First named as leukemia in 1845, the First of a live case of CML patient diagnosed in 1846, the First used of arsenic in CML treatment in 1865, the First defined as a myeloproliferative disorder in 1951, the First finding of Philadelphia chromosome (Ph chromosome) in 1960, the First finding of chromosome 9 and 22 translocations in 1973, the First identified as a clonal hematological malignancy derived from the stage of pluripotent bone hematopoietic stem cells in 1977, the First finding of the chromosomal fusion gene-BCR-ABL as an oncogene in 1984, and the First designed target therapy of use of tyrosine kinase inhibitor (TKI) in 1998. The footprints of the studies on CML established the milestone histories. Remarkable and fascinating genetic discoveries were made of the mysteries of human diseases, the multiway translocation of Ph chromosome, and the latest issues. The association of the combination of chronic myeloid leukemia and chronic lymphocytic leukemia will be reviewed in this chapter with the aim of increasing the understanding of CML further from laboratory bench to clinical bedside.

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Section: Issues Of the Combination Of CML And Chronic Lymphocytic Leumentioning

confidence: 99%

Milestone Histories and Paradigmatic Genetic Discoveries of Chronic Myeloid Leukemia (CML)

Wu¹

2020

Rare Diseases

View full text Add to dashboard Cite

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Combined CML and CLL in four patients, including one with 17p deletion

Cited by 1 publication

References 0 publications

Milestone Histories and Paradigmatic Genetic Discoveries of Chronic Myeloid Leukemia (CML)

Milestone Histories and Paradigmatic Genetic Discoveries of Chronic Myeloid Leukemia (CML)

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