Combined clear and granular cell leiomyoma of soft tissue: evidence of transformation to a histiocytic phenotype

Dobashi, Yoh; Iwabuchi, Kazuya; Nakahata, Junichi; Yanagimoto, Kunio; Kameya, T

doi:10.1111/j.1365-2559.1999.00680.x

Cited by 15 publications

(8 citation statements)

References 18 publications

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“…However, the evidence of ultrastructural and immunohistochemical observations have suggested that a small number of granular cell tumor arises from non‐neural cells. The granular cell tumor comprises a heterogeneous group of neoplasms, so some researchers have adapted the term granular cell leiomyoma or leiomyosarcoma to differentiate it from granular cell schwannoma (Suster et al., 1988; Shimokama and Watanabe, 1992; Dobashi et al., 1999).…”

Section: Discussionmentioning

confidence: 99%

A Malar Granular Cell Tumor in a Djungarian Hamster

Sato

Takada

Shibuya

et al. 2004

Journal of Veterinary Medicine Series A

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'Granular cell' tumor observed in the malar subcutis of a Djungarian hamster was examined to determine its cellular origin. Histologically, the tumor consisted of a solid growth of oval or spindle-shaped large cells with abundant cytoplasm filled with eosinophilic granules that were periodic acid-Schiff-positive and diastase-resistant. Immunohistochemically, the tumor cells were positive to anti-vimentin and anti-desmin antibodies and a few cells showed positivity to anti-actin antibody as well. They did not react to myoglobin, S-100 protein, and glial fibrillary acidic protein (GFAP). Electron microscopic studies revealed that the tumor cells had pinocytotic vesicles, dense plaque and microfilaments. The first granular cell variant of myogenic tumor reported here in Djungarian hamsters was differentiated from granular cell tumor of Schwann cell origin.

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Section: Discussionmentioning

confidence: 99%

A Malar Granular Cell Tumor in a Djungarian Hamster

Sato

Takada

Shibuya

et al. 2004

Journal of Veterinary Medicine Series A

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“…Granular cell differentiation is due to an increased number of secondary lysosomes and hallmarked by the presence of abundant eosinophilic granularity of cytoplasm. In the differential diagnosis of GCT, we consider leiomyoma [10], schwannoma [11,12], GIST [6] and xanthoma in GI tract, leiomyoma [13,14], neurofibroma, dermatofibroma, melanocytic nevi [15] and xanthalesma in the skin lesions and fibroma in the oral lesions. In our study, Nestin was positive in GISTs, schwannomas and neurofibromas.…”

Section: Discussionmentioning

confidence: 99%

Granüler hücreli tümör tanısında Nestin immunhistokimyasının kullanımı

Erinanç¹,

Gokturk²,

Unler³

et al. 2018

Archives of Clinical and Experimental Medicine

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Aim: Granular cell tumors (GCTs) show neuroectodermal differentiation. Morphologically, a wide variety of mesencymal tumors may have granular cell appearance. Nestin, which is an intermediate filament protein expressed in undifferentiated cells during central nerves system development and its tumors. We aim to determine the diagnostic utility of Nestin in diagnosis of GCTs. Methods: Nestin immunohistochemistry applied to GCT cases and other mesenchymal tumors which may have granular cytoplasm and the major differential diagnostic consideration of GCT. A total of 21 GCT from different tissues (including 7 in the esophagus, 8 originating from skin tissues, 4 in the tongue, 2 in the vocal cord), 17 gastrointestinal stromal tumor in the gastrointestinal tract, 8 leiomyoma (5 in the esophagus and 3 originating from skin tissues), 4 schwannoma (1 in the esophagus and 3 originating from skin tissues), subcutaneous mesenchymal tumors ( including 7 neurofibroma, 5 fibroma, 15 dermatofibroma), 20 melanocytic nevi, 15 gastric xanthomas and 15 xanthalesma of the skin were included the study. Results: Nestin positivity was detected in all GCTs. Additionally, strong Nestin positivity was seen in all gastrointestinal stromal tumors, schwannoma and neurofibroma cases. However, Nestin was negative in all leiomyoma, fibroma, dermatofibroma, melanocytic nevi, gastric xanthoma and xanthalesma cases. Conclusion: The study showed that Nestin immunohistochemistry has limitation in distinction of GCT from tumors arising from neural cell lineage such as gastrointestinal stromal tumor, schwannoma and neurofibroma; however, Nestin as a neural marker provides an evidence to neural origin of GCT and could be useful in distinction GCT from other mesenchymal tumors with granular cytoplasm such as leiomyoma, dermatofibroma and melanocytic nevi.

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“…Much has been discussed about the granular nature of GCT cells. Generally, it is believed that it is a response of the tissue to many factors, such as: neoplasia, degenerative or reactive processes like anoxia, metabolic disorders and lysosomic effects (6,7). In the oral cavity, other benign tumors can present granular cells such as granular cell leiomyoma, nonneural granular cell tumor, congenital epulis and also malignancies such as alveolar soft part sarcoma (4).…”

Section: Discussionmentioning

confidence: 99%

The neural histogenetic origin of the oral granular cell tumor: An immunohistochemical evidence

Ra¹,

Ms²,

Cortes³

et al. 2011

Med Oral

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Aims: Granular cell tumor (GCT) is a rare neoplasm that can appear in any site of the body, but most are located intraorally. Its histogenetic origin remains unclear. This report analyzes the immunoprofile of 15 cases of granular cell tumors, occurring in 13 women and 2 men and the lesions were located on the tongue or upper lip. Patient age ranged from 7 to 52. Methods: The patients demographic data and the cytological and architectural features of the lesions were analyzed in oral GCTs (n = 15). The lesions were also submitted to a panel of immunohistochemical stains with antibodies against S-100, p75, NSE, CD-68, Ki-67, Synaptofisin, HHF-35, SMA, EMA, Chromogranin, Progesterone, Androgen and Estrogen. Results: Among the fifteen cases analyzed, the most common location was the tongue (84.6%). Histologically, the tumors exhibited cellular proliferation composed mainly by polygonal cells presenting an abundant granular eosinophilic cytoplasm. The nuclei were central, and the cell membranes were moderately clear. No mitotic figures were observed. The immunohistochemical analysis showed positivity in all cases for S-100, p75, NSE and CD-68, and no immunoreactivity for Ki-67, Synaptofisin, HHF-35, SMA, EMA, Chromogranin, Progesterone, Androgen and Estrogen. Conclusion: The immunoprofile of granular cell tumors showed nerve sheath differentiation -lending support to their neural origin -and helping to establish a differential diagnosis between this lesion and other oral granular cell tumors, whether benign or malignant.

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Combined clear and granular cell leiomyoma of soft tissue: evidence of transformation to a histiocytic phenotype

Cited by 15 publications

References 18 publications

A Malar Granular Cell Tumor in a Djungarian Hamster

A Malar Granular Cell Tumor in a Djungarian Hamster

Granüler hücreli tümör tanısında Nestin immunhistokimyasının kullanımı

The neural histogenetic origin of the oral granular cell tumor: An immunohistochemical evidence

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