Combined ciprofloxacin/rifampicin therapy in methicillin‐resistant<i>Staphylococcus aureus</i>(MRSA) infection

Cheong, I; Zin, Zainuddin; Tan, Seng Chye; Wong, Yick Hei; Rahman, Mohd Z A

doi:10.5694/j.1326-5377.1992.tb121632.x

Cited by 4 publications

(5 citation statements)

References 7 publications

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“…In another report by the author, 35% of clinical isolates of S. aureus in the same hospital in 1990‐1991 were cases of MRSA 6 . The present finding reaffirms that initial finding, suggesting that despite preventive measures following the initial report, MRSA is fairly well entrenched in the hospital and will continue to contribute to future patient morbidity and mortality.…”

Section: Discussionsupporting

confidence: 83%

“…Since then, MRSA colonisation/infection has spread to many community hospitals in the country. The percentages of MRSA of the total Staphylococus aureus isolates at the Hospital Kuala Lumpur between 1987 and 1990 were 23.4%, 27.0%, 22.2% and 25.5%, respectively 6 . This paper describes our experience with 25 cases of MRSA bacteraemia seen between July and December 1994 in the same hospital.…”

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confidence: 91%

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METHICILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS BACTERAEMIA AT A TERTIARY TEACHING HOSPITAL

Cheong

Samsudin

Law

1996

Int J Clinical Practice

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SUMMARY Between July and December 1994, 25 patients with MRSA bacteraemia were treated at the Hospital Kuala Lumpur, a tertiary hospital in Malaysia with 3000 beds. The patients included 15 males and 10 females whose mean age was 46.7 years (range 13‐75). The sources of their MRSA were: Urology/Nephrology, 11; General ICU, six; Orthopaedic, four; Medicine, three; Surgery, one. Their underlying diseases were: end‐stage and chronic renal failure, 11; burns, three; acute necrotising pancreatitis, two; haematological malignancies, two; and one each of fracture of the neck of the femur, pustular psoriasis, alcoholic cirrhosis, liver abscess, peptic ulcer (antrectomy), choledochol cyst, and abdominal aneurysm with gangrene of the legs. Six patients were also diabetic. A total of 19 infections were considered nosocomial. The duration of hospital stay ranged from one to 60 days, mean 16 days. On the day of blood culture, 20 patients (80%) were febrile and 15 (60%) had leucocytosis. A total of 14 patients were considered to have received prolonged broad‐spectrum antibiotics before the bacteraemia; of these, 11 had had either a third‐generation cephalosporin and/or a quinolone. The primary foci of infection were: vascular access dialysis catheters, six; infected AV fistulae, three; non‐surgical wounds, five; orthopaedic pin, one; multiple venous lines and catheters, nine; unknown, one. The sensitivities to anti‐MRSA antibiotics were: vancomycin, 100%; fusidic acid, 96%; rifampicin, 96%; ciprofloxacin and perfloxacin 28% each. In all, 13 patients (52%) eventually died; nine of these deaths were directly attributed to MRSA bacteraemia. The microbiological eradication rate was 88%. Mortality was significantly associated with duration of hospital stay and failure to remove the infected catheters/peripheral lines after the development of MRSA bacteraemia.

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Section: Discussionsupporting

confidence: 83%

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confidence: 91%

METHICILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS BACTERAEMIA AT A TERTIARY TEACHING HOSPITAL

Cheong

Samsudin

Law

1996

Int J Clinical Practice

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“…Unfortunately, epidemiological data on MRSA in Malaysian neonates are scarce and limited to one or two centers of study. For instance, in the 1990s, Cheong et al (1994) found a high number of MRSA isolates (26.3%, 142/539) in the pediatric and special care nurseries of two Kuala Lumpur hospitals between August 1990 and November 1991 [ 20 ]. In the late 2000s, Kuala Lumpur Hospital reported an MRSA rate of 9.2% (174/1887) in pediatrics patients between October 2007 and September 2008 [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus Associated with Hospitalized Newborn Infants

et al. 2023

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Multidrug resistance (MDR) is a significant challenge in healthcare management, and addressing it requires a comprehensive approach. In this study, we employed a combination of phenotypic and genotypic approaches, along with whole genome sequencing (WGS) to investigate five hospital-associated MDR methicillin-resistant Staphylococcus aureus (MRSA) strains that were isolated from newborn infants. Our analysis revealed the following for the MDR-MRSA strains: SauR31 was resistant to three antimicrobial classes; SauR12, SauR91 and SauR110 were resistant to four antimicrobial classes; and SauR23 exhibited resistance to seven classes. All the MDR-MRSA strains were capable of producing slime and biofilms, harbored SCCmec type IV, and belonged to different spa types (t022, t032, and t548), with varying profiles for microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) and virulence genes. The WGS data for the MDR SauR23 and SauR91 strains revealed that most of the antimicrobial resistance genes were present in the chromosomes, including blaZ, mecA, norA, lmrS, and sdrM, with only the ermC gene found in a small (<3 kb) plasmid. The presence of MDR-MRSA strains among neonates raises public concern, hence implementation of multifaceted interventions is recommended to address this issue. In addition, metadata is needed to improve the investigation of antimicrobial resistance genes in MDR isolates.

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“…An arising number of MRSA infections was encountered in Malaysian hospitals since the mid 1970s. The increment has been noted in large tertiarycare teaching hospitals as well as in community hospitals [20][21]. The ability of S. aureus to develop and acquire antimicrobial resistance has ushered to the emergence of multidrug resistant strains such as MRSA.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Susceptibility Profiles of Staphylococcus Aureus in Hospital Angkatan Tentera Tuanku Mizan (Hattm), Malaysia: A Preliminary Study

Mohamed Shakrin,

Amat Junaidi,

Daman Huri

et al. 2021

ZJDSET

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Background: Staphylococcus aureus is a human pathogen causing a variety of diseases ranging from superficial skin and soft-tissue infections to life-threatening infections. Nowadays, the treatment has become complicated due to the emergence of methicillin-resistant S. aureus (MRSA). It is an established pathogen that causes hospital- and community-acquired infections worldwide. This study was a preliminary retrospective study involving S. aureus clinical isolates from Hospital Angkatan Tentera Tuanku Mizan (HATTM) for a period of 6 months (October 2018 until March 2019). Objectives: The study was conducted to determine the S. aureus antibiotic susceptibility profiles and its association with types of infection, gender, wards, age of patients and types of specimens. Methods: Standard bacteriological method was used for S. aureus isolation from various clinical specimens including blood, urine, pus and wound, eye, throat, nasal, pericardial fluid, tracheal aspirate, high vagina swab (HVS), bronchial alveolar lavage (BAL) and tissue. Kirby-Bauer disc diffusion method was utilized for antibiotic susceptibility profiles determination. Results: Ninety-five S. aureus strains were isolated from 3571 specimens. Twenty-six of the isolates (27%) was identified as MRSA and 69 (73%) was identified as methicillin-sensitive S. aureus (MSSA). Among the MRSA, 4 isolates were hospital-acquired MRSA (HA-MRSA) and the rest were community-acquired MRSA (CA-MRSA). There was a statistically significant association between isolation of MRSA with age of patient as well as types of infection or origin of the MRSA (p<0.05). Only 42 (44.2%) of the S. aureus isolates were fully susceptible to all antibiotics. Almost half isolates (n=46, 48.4%) were resistant to at least two antibiotics and seven (7.4%) isolates were resistant to one type of antibiotic only. Conclusions: None of the isolate showed reduced susceptibility nor resistant to vancomycin. Future study with a larger sample size using a wider study period needs to be done to confirm that vancomycin-resistant S. aureus has not yet been established in HATTM.

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Combined ciprofloxacin/rifampicin therapy in methicillin‐resistantStaphylococcus aureus(MRSA) infection

Cited by 4 publications

References 7 publications

METHICILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS BACTERAEMIA AT A TERTIARY TEACHING HOSPITAL

METHICILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS BACTERAEMIA AT A TERTIARY TEACHING HOSPITAL

Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus Associated with Hospitalized Newborn Infants

Antibiotic Susceptibility Profiles of Staphylococcus Aureus in Hospital Angkatan Tentera Tuanku Mizan (Hattm), Malaysia: A Preliminary Study

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