Combined change of behavioral traits for domestication and <scp>gene‐networks</scp> in mice selectively bred for active tameness

Matsumoto, Yuki; Nagayama, Hiromichi; Nakaoka, Hirofumi; Toyoda, Atsushi; Goto, Tatsuhiko; Koide, Tsuyoshi

doi:10.1111/gbb.12721

Cited by 9 publications

(17 citation statements)

References 48 publications

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“…Further genetic analysis and transcriptome analyses found several candidate genes for tameness, such as Slc6a4 , Oxtr , etc . 27 , 42 . The limitation with using heterogeneous stock was a lack of a method for genetic engineering in the genetically heterogeneous population, because the mice group is an outbred stock and is derived from eight wild strains.…”

Section: Discussionmentioning

confidence: 99%

Efficient genome editing in wild strains of mice using the i-GONAD method

Imai

Tanave

Matsuyama

et al. 2022

Sci Rep

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Wild mouse strains have been used for many research studies, because of the high level of inter-strain genetic and phenotypic variations in them, in addition to the characteristic phenotype maintained from wild mice. However, since application of the current genetic engineering method on wild strains is not easy, there are limited studies that have attempted to apply gene modification techniques in wild strains. Recently, i-GONAD, a new method for genome editing that does not involve any ex vivo manipulation of unfertilized or fertilized eggs has been reported. We applied i-GONAD method for genome editing on a series of wild strains and showed that genome editing is efficiently possible using this method. We successfully made genetically engineered mice in seven out of the nine wild strains. Moreover, we believe that it is still possible to apply milder conditions and improve the efficiencies for the remaining two strains. These results will open avenues for studying the genetic basis of various phenotypes that are characteristic to wild strains. Furthermore, applying i-GONAD will be also useful for other mouse resources in which genetic manipulation is difficult using the method of microinjection into fertilized eggs.

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Section: Discussionmentioning

confidence: 99%

Efficient genome editing in wild strains of mice using the i-GONAD method

Imai

Tanave

Matsuyama

et al. 2022

Sci Rep

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“…However, we did not find any signs of other features related to the domestication syndrome. The oxytocin receptor gene, which is involved in social preference, was identified as a candidate gene that was differentially expressed in selected tame groups 37 . Thus, the mechanisms underlying active tameness and sociability may be similar.…”

Section: Discussionmentioning

confidence: 99%

“…Within 12 generations of breeding, the selected WHS groups exhibited higher active tameness than the control groups 33 . The difference in active tameness was more evident in the 16th generation, suggesting that alleles related to active tameness became more abundant in later generations of the selected groups 37 …”

Section: Introductionmentioning

confidence: 93%

“…33 The difference in active tameness was more evident in the 16th generation, suggesting that alleles related to active tameness became more abundant in later generations of the selected groups. 37 Given that the selected and control groups originated from the same stock of the WHS, the difference observed between these groups is likely to be caused by selecting only for a behavioural phenotype of active tameness. These groups of mice are useful for examining how selection for active tameness, a phenotype related to the domestication of animals, changes other behavioural phenotypes and traits associated with the domestication syndrome.…”

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Association of tameness and sociability but no sign of domestication syndrome in mice selectively bred for active tameness

Venkatachalam,

Biswa,

Nagayama

et al. 2024

Genes Brain and Behavior

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Domesticated animals have been developed by selecting desirable traits following the initial unconscious selection stage, and now exhibit phenotypes desired by humans. Tameness is a common behavioural trait found in all domesticated animals. At the same time, these domesticated animals exhibit a variety of morphological, behavioural, and physiological traits that differ from their wild counterparts of their ancestral species. These traits are collectively referred to as domestication syndrome. However, whether this phenomenon exists is debatable. Previously, selective breeding has been used to enhance active tameness, a motivation to interact with humans, in wild heterogeneous stock mice derived from eight wild inbred strains. In the current study, we used tame mice to study how selective breeding for active tameness affects behavioural and morphological traits. A series of behavioural and morphological analyses on mice showed an increased preference for social stimuli and a longer duration of engagement in non‐aggressive behaviour. However, no differences were observed in exploratory or anxiety‐related behaviours. Similarly, selection for tameness did not affect ultrasonic vocalisations in mice, and no changes were observed in known morphological traits associated with domestication syndrome. These results suggest that there may be a link between active tameness and sociability and provide insights into the relationship between tameness and other behaviours in the context of domestication.

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“…Characterizing an archetype opens potential for testing Darwin’s [2] two-step model of domestication as an alternative to the hypothesis that domestication represents a continuum [5]. Under the scenario that the dingo has been unconsciously selected, we predict genomic signatures of tameness, as an outcome of unconscious selection [100-102]. Morphologically, we predict lowest shape variation in the rostrum and facial skeleton in the wolf (natural selection), intermediate in the dingo (unconscious selection) and highest in domestic breeds (artificial selection) (i.e., rank order wolf< dingo < modern breeds).…”

Section: Discussionmentioning

confidence: 99%

The Australasian dingo archetype:De novochromosome-length genome assembly, DNA methylome, and cranial morphology

Ballard

Field

Edwards

et al. 2023

Preprint

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Background: One difficulty in testing the hypothesis that the Australasian dingo is a functional intermediate between wild wolves and domesticated breed dogs is that there is no reference specimen. Here we link a high-quality de novo long read chromosomal assembly with epigenetic footprints and morphology to describe the Alpine dingo female named Cooinda. It was critical to establish an Alpine dingo reference because this ecotype occurs throughout coastal eastern Australia where the first drawings and descriptions were completed. Findings: We generated a high-quality chromosome-level reference genome assembly (Canfam_ADS) using a combination of Pacific Bioscience, Oxford Nanopore, 10X Genomics, Bionano, and Hi-C technologies. Compared to the previously published Desert dingo assembly, there are large structural rearrangements on Chromosomes 11, 16, 25 and 26. Phylogenetic analyses of chromosomal data from Cooinda the Alpine dingo and nine previously published de novo canine assemblies show dingoes are monophyletic and basal to domestic dogs. Network analyses show that the mtDNA genome clusters within the southeastern lineage, as expected for an Alpine dingo. Comparison of regulatory regions identified two differentially methylated regions within glucagon receptor GCGR and histone deacetylase HDAC4 genes that are unmethylated in the Alpine dingo genome but hypermethylated in the Desert dingo. Morphological data, comprising geometric morphometric assessment of cranial morphology place dingo Cooinda within population-level variation for Alpine dingoes. Magnetic resonance imaging of brain tissue show she had a larger cranial capacity than a similar-sized domestic dog. Conclusions: These combined data support the hypothesis that the dingo Cooinda fits the spectrum of genetic and morphological characteristics typical of the Alpine ecotype. We propose that she be considered the archetype specimen for future research investigating the evolutionary history, morphology, physiology, and ecology of dingoes. The female has been taxidermically prepared and is now at the Australian Museum, Sydney.

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Combined change of behavioral traits for domestication and gene‐networks in mice selectively bred for active tameness

Cited by 9 publications

References 48 publications

Efficient genome editing in wild strains of mice using the i-GONAD method

Efficient genome editing in wild strains of mice using the i-GONAD method

Association of tameness and sociability but no sign of domestication syndrome in mice selectively bred for active tameness

The Australasian dingo archetype:De novochromosome-length genome assembly, DNA methylome, and cranial morphology

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