Combined cerium oxide nanocapping and layer-by-layer coating of porous silicon containers for controlled drug release

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

“…Ceria-containing LbL antioxidant coatings have shown great promise in both cellular implantation and in areas where mitigation of chronic inflammation is desired. Implantable drug delivery systems have been designed by Sedighi et al to achieve controlled and sustained drug release [ 73 ]. Curcumin as a model drug was loaded into porous silicon containers (8.94 ± 0.72% w/w); then the containers were capped with cerium oxide nanoparticles for drug protection and release prolongation following layer-by-layer surface coating of the container with anionic (alginate) and cationic (chitosan) polymers, thus providing pH sensitivity.…”

Preparation and characterization of pH-sensitive hydrogels from photo-crosslinked poly(ethylene glycol) diacrylate incorporating titanium dioxide

“…Drug delivery systems improve bioavailability, selectivity, and release profile of therapeutic agents. These systems can maintain precise control over drug concentration within the therapeutic window [8,9]. Also, controlled drug delivery has * E-mail: eakyol@yildiz.edu.tr a robust structure and large loading capacity of hydrophilic drugs [10][11][12].…”

Controlled Tyrosine Kinase Inhibitor Delivery to Liver Cancer Cells by Gate-Capped Mesoporous Silica Nanoparticles

“…17,20 Utilization of gatekeepers, which block the MSN pores upon drug loading, is a promising approach to inhibit the undesired release and improve cellular internalization and intracellular drug delivery. 21 Inorganic nanoparticles (NPs), such as gold NPs and superparamagnetic iron oxide NPs with small size diameters, have been used to cap pores of nanostructures, endowing nanocomposites with dual functionality. 22,23 In addition to these nanomaterials, cerium oxide NPs (CNPs) have drawn attention due to their high biocompatibility and potential therapeutic functionalities, such as anticancer effects, as well as neuroprotective, cardioprotective, and anti-inflammatory potentials.…”

“…30 In addition, CNPs can be reduced to cerium ions in the presence of reducing agents, providing great potential for the development of smart stimuli-responsive nanocomposites. 21,31 Herein we developed a TKI encapsulating nanocomposite based on amine-functionalized MSNs (NH 2 -MSN) capped with CNPs to overcome undesirable characteristics such as poor colloidal stability, burst drug release, protein corona formation, and low cellular uptake of particles. Particularly, we aimed to combine the specific pH and redox responsive characteristics of small CNPs with the advantageous physicochemical and biological properties of MSNs in a single nanocomposite system.…”

“…However, despite a high pharmacological activity, the effectiveness of SFN is limited by its relatively low bioavailability, which is related to its low aqueous solubility . In this respect, porous nanomaterials have recently demonstrated a significant impact on enhancing the solubility of poorly water-soluble drugs by confining them in their amorphous state. , Among the large variety of available porous nanostructures, mesoporous silica nanoparticles (MSNs) have spearheaded the field of solid nanocarriers due to their biodegradability, the feasibility of surface modification, tunable nanoscale size, controllable shape and pore size, large pore volume and surface area, as well as high surface-to-volume ratio. , In addition to rendering enhancement of drug solubility, bioavailability, and antitumor activity, MSNs can be used for the development of theranostics or multitherapeutic nanosystems. − Nonetheless, several bottlenecks, such as high burst release and rapid aggregation limit the widespread application of mesoporous materials in nanomedicine. − In addition, low cellular association, internalization, and subsequent incapacity for the intracellular endosomal escape might reduce their therapeutic efficiency. , Utilization of gatekeepers, which block the MSN pores upon drug loading, is a promising approach to inhibit the undesired release and improve cellular internalization and intracellular drug delivery . Inorganic nanoparticles (NPs), such as gold NPs and superparamagnetic iron oxide NPs with small size diameters, have been used to cap pores of nanostructures, endowing nanocomposites with dual functionality. , In addition to these nanomaterials, cerium oxide NPs (CNPs) have drawn attention due to their high biocompatibility and potential therapeutic functionalities, such as anticancer effects, as well as neuroprotective, cardioprotective, and anti-inflammatory potentials. − In the cancer microenvironment, CNPs can create reactive oxygen species (ROS) in cancer cells, resulting in apoptosis, while, at the same time, CNPs have the capability of protecting healthy cells from the degenerative effect of ROS production .…”