Combined central odontogenic fibroma and giant cell granuloma-like lesion of the mandible: Report of a case and review of the literature

So-called Hybrid Central Odontogenic Fibroma/Central Giant Cell Lesion of the Jaws. A Report on Seven Additional Cases, Including an Example in a Patient with Cherubism, and Hypotheses on the Pathogenesis

“…Histologically, COF and CGCL areas can be either distinct and separate, with occasional foci of CGCL surrounded by large zones or septa of COF, or traversing and intermingling [9,10]. In all examples, the COF areas did not feature dysplastic dentin or cementum.…”

“…''Giant cell reaction'' was found by Fowler et al [8] in 3 of 24 central odontogenic fibromas, while Odell et al [9] gave detailed microscopic description of 8 patients with ''hybrid central giant cell granuloma and central odontogenic fibroma-like'' (hCOF/CGCL). A patient with ''combined central odontogenic fibroma and giant cell granuloma-like lesion'' was described by Mosqueda-Taylor et al [10]. Finally, Kessler presented a case diagnosed as central odontogenic fibroma with central giant cell granuloma in the 2006 Meeting of the Western Society of Teachers of Oral Pathology bringing the total number of reported patients, known to the authors, to 16.…”

Odontogenic Fibroma, Including Amyloid and Ossifying Variants

“…The concomitant occurrence of odontogenic fibroma and central giant cell lesion, while rare, is well documented [37][38][39][40]. The congeniality of these two entities growing side by side is a special and significant event.…”

Simultaneous occurrence of an odontogenic keratocyst and giant cell granuloma-like lesion in the mandible

“…There are no reports in the literature of a GCG developing in association with an OKC, but several investigators have reported cases of odontogenic fibroma and ameloblastoma associated with giant cell reaction 1,3,6,8,9 . This combination was interpreted as an odontogenic tumor in which there was a reactive giant cell component rather than a collision lesion 1,6,8,9 . The giant cell reaction in the odontogenic fibroma may have a reactive origin because of the small amount of the GCG component 1,8 .…”

“…This combination was interpreted as an odontogenic tumor in which there was a reactive giant cell component rather than a collision lesion 1,6,8,9 . The giant cell reaction in the odontogenic fibroma may have a reactive origin because of the small amount of the GCG component 1,8 . Its explanation might be applicable to this case.…”