Combined cancer therapy with hyaluronan-decorated fullerene-silica multifunctional nanoparticles to target cancer stem-like cells

Evolving understanding of structural and biological complexity of tumors has stimulated development of physiologically relevant tumor models for cancer research and drug discovery. A major motivation for developing new tumor models is to recreate the 3D environment of tumors and context-mediated functional regulation of cancer cells. Such models overcome many limitations of standard monolayer cancer cell cultures. Under defined culture conditions, cancer cells self-assemble into 3D constructs known as spheroids. Additionally, cancer cells may recapitulate steps in embryonic development to self-organize into 3D cultures known as organoids. Importantly, spheroids and organoids reproduce morphology and biologic properties of tumors, providing valuable new tools for research, drug discovery, and precision medicine in cancer. This Progress Report discusses uses of both natural and synthetic biomaterials to culture cancer cells as spheroids or organoids, specifically highlighting studies that demonstrate how these models recapitulate key properties of native tumors. The report concludes with the perspectives on the utility of these models and areas of need for future developments to more closely mimic pathologic events in tumors.

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Section: Figurementioning

confidence: 99%

Biomaterials‐Based Approaches to Tumor Spheroid and Organoid Modeling

Thakuri

Liu

Luker

et al. 2017

Adv Healthcare Materials

102

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“…The release of drug molecules from the eukaryotic cell‐like hybrid nanoparticles can be precisely regulated by the near‐IR laser irradiation. The same research group have also synthesized hyaluronan‐decorated hybrid nanoparticles of silica and C 60 for a combined cancer therapy to target cancer stem‐like cells, which by nature are typically resistant to chemotherapy, highly tumourigenic and aggressive. The hyaluronan‐covered hybrid nanoparticles can encapsulate both doxorubicin hydrochloride and indocyanine green with extremely high encapsulation efficiency and loading.…”

Section: From the Nano‐world: Fullerene‐based Hybrid Nanoarchitectonicsmentioning

confidence: 99%

Nanoarchitectonics for Hybrid and Related Materials for Bio‐Oriented Applications

Ariga

Leong

Mori

2017

Adv Funct Materials

152

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Atom/molecular-level controls in nanotechnology are important for the precise placement of components in device applications. Despite many advances, nanotechnology still uses simple systems to make precise atom/ molecule-scale changes. This is in contrast with the many phenomena observed in biological systems, where there appears to be a well-designed integrative approach involving molecular units to achieve atomic-and molecular-scale changes. Inspired by nature, we introduced a novel concept-nanoarchitectonics-to develop nanoscale functional materials for bio-oriented applications. Nanoarchitectonics is a unified concept combining nanotechnology and methodologies in related research fields, such as supramolecular chemistry, self-assembly, and self-organization, to satisfy the major features of nanosciences for the creation of functional materials or even devices and machines. This concept guides the harmonized assembly of nanoscale objects into higher order functional materials. In this Feature Article, recent research activities are introduced regarding the development of advanced functional materials of hybrid and related architectures on the basis of nanoarchitectonics from diverse contexts of organic and inorganic materials: i) from biology (DNA-based hybrid); ii) from geology (clay-based hybrid); iii) from 0D nanotechnology (fullerene-based hybrid); and iv) from other nanoarchitectonics. Therefore, this Feature Article showcases some examples of the nanoarchitectonic concepts at work in diverse material types.

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“…[7,8] However, complicated fabrication and compositions often increase the cost and require better quality control, which bring obstacles to industrial production and clinical translation. [9,10] Moreover, balancing the ratio of loading agents also compromises their therapeutic and imaging effect and increases the chance of instability. [11] Therefore, simple theranostic nanoplatform with a high performance of curative effect and imaging function should be explored to overcome these challenges.…”

Section: Introductionmentioning

confidence: 99%

Single‐Photomolecular Nanotheranostics for Synergetic Near‐Infrared Fluorescence and Photoacoustic Imaging‐Guided Highly Effective Photothermal Ablation

Xiao

Xiang

et al. 2020

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Multi‐modality imaging‐guided cancer therapy is considered as a powerful theranostic platform enabling simultaneous precise diagnosis and treatment of cancer. However, recently reported multifunctional systems with multiple components and sophisticate structures remain major obstacles for further clinical translation. In this work, a single‐photomolecular theranostic nanoplatform is fabricated via a facile nanoprecipitation strategy. By encapsulating a semiconductor oligomer (IT‐S) into an amphiphilic lipid, water‐dispersible IT‐S nanoparticles (IT‐S NPs) are prepared. The obtained IT‐S NPs have a very simple construction and possess ultra‐stable near‐infrared (NIR) fluorescence (FL)/photoacoustic (PA) dual‐modal imaging and high photothermal conversion efficiency of 72.3%. Accurate spatiotemporal distribution profiles of IT‐S NPs are successfully visualized by NIR FL/PA dual‐modal imaging. With the comprehensive in vivo imaging information provided by IT‐S NPs, tumor photothermal ablation is readily realized under precise manipulation of laser irradiation, which greatly improves the therapeutic efficacy without any obvious side effects. Therefore, the IT‐S NPs allow high tumor therapeutic efficacy under the precise guidance of FL/PA imaging techniques and thus hold great potential as an effective theranostic platform for future clinical applications.

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Combined cancer therapy with hyaluronan-decorated fullerene-silica multifunctional nanoparticles to target cancer stem-like cells

Cited by 89 publications

References 38 publications

Biomaterials‐Based Approaches to Tumor Spheroid and Organoid Modeling

Biomaterials‐Based Approaches to Tumor Spheroid and Organoid Modeling

Nanoarchitectonics for Hybrid and Related Materials for Bio‐Oriented Applications

Single‐Photomolecular Nanotheranostics for Synergetic Near‐Infrared Fluorescence and Photoacoustic Imaging‐Guided Highly Effective Photothermal Ablation

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