Combined Assessment of Preoperative Frailty and Sarcopenia Allows the Prediction of Overall Survival in Patients with Lung Cancer (NSCLC) and Surgically Treated Brain Metastasis

Ilic, Inja; Faron, Anton; Heimann, Muriel; Potthoff, Anna-Laura; Schäfer, Niklas; Bode, Christian; Borger, Valeri; Eichhorn, Lars; Giordano, Frank A.; Güresir, Erdem; Ko, Yon‐Dschun; Landsberg, Jennifer; Lehmann, Felix; Radbruch, Alexander; Herrlinger, Ulrich; Vatter, Hartmut; Schuss, Patrick; Schneider, Matthias

doi:10.3390/cancers13133353

Cited by 24 publications

(16 citation statements)

References 31 publications

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“…Since this report, there have been several papers on the temporalis muscle and prognosis, especially in brain tumors. There are several reports on overall survival and temporal muscle in glioblastoma [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ], metastatic brain tumor [ 31 , 46 , 47 ], and primary central nervous system lymphoma [ 37 , 48 ]. As in reports on TMT and stroke, all of these reports used temporal muscle to indicate nutritional status and skeletal muscle mass volume.…”

Section: Discussionmentioning

confidence: 99%

Temporal Muscle and Stroke—A Narrative Review on Current Meaning and Clinical Applications of Temporal Muscle Thickness, Area, and Volume

et al. 2022

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Background: Evaluating muscle mass and function among stroke patients is important. However, evaluating muscle volume and function is not easy due to the disturbances of consciousness and paresis. Temporal muscle thickness (TMT) has been introduced as a novel surrogate marker for muscle mass, function, and nutritional status. We herein performed a narrative literature review on temporal muscle and stroke to understand the current meaning of TMT in clinical stroke practice. Methods: The search was performed in PubMed, last updated in October 2021. Reports on temporal muscle morphomics and stroke-related diseases or clinical entities were collected. Results: Four studies reported on TMT and subarachnoid hemorrhage, two studies on intracerebral hemorrhage, two studies on ischemic stroke, two studies on standard TMT values, and two studies on nutritional status. TMT was reported as a prognostic factor for several diseases, a surrogate marker for skeletal muscle mass, and an indicator of nutritional status. Computed tomography, magnetic resonance imaging, and ultrasonography were used to measure TMT. Conclusions: TMT is gradually being used as a prognostic factor for stroke or a surrogate marker for skeletal muscle mass and nutritional status. The establishment of standard methods to measure TMT and large prospective studies to further investigate the relationship between TMT and diseases are needed.

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Section: Discussionmentioning

confidence: 99%

Temporal Muscle and Stroke—A Narrative Review on Current Meaning and Clinical Applications of Temporal Muscle Thickness, Area, and Volume

et al. 2022

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“…Age itself seems to play an equally important role with regard to OS in patients with surgically treated BM, as shown by the present multivariate analysis. Apart from intratumoral hemorrhage, (older) age is an important prognostic factor for overall survival in patients with BM (15)(16)(17). Older age might also lead to an increased correlating burden of comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Metastatic Brain Tumor-Associated Intracerebral Hemorrhage Is Associated With Dismal Prognosis

et al. 2021

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ObjectIntra-tumoral hemorrhage is considered an imaging characteristic of advanced cancer disease. However, data on the influence of intra-tumoral hemorrhage in patients with brain metastases (BM) remains scarce. We aimed at investigating patients with BM who underwent neurosurgical resection of the metastatic lesion for a potential impact of preoperative hemorrhagic transformation on overall survival (OS).MethodsBetween 2013 and 2018, 357 patients with BM were surgically treated at the authors’ neuro-oncological center. Preoperative magnetic resonance imaging (MRI) examinations were assessed for the occurrence of malignant hemorrhagic transformation.Results122 of 375 patients (34%) with BM revealed preoperative intra-tumoral hemorrhage. Patients with hemorrhagic transformed BM exhibited a median OS of 5 months compared to 12 months for patients without intra-tumoral hemorrhage. Multivariate analysis revealed preoperative hemorrhagic transformation as an independent and significant predictor for worsened OS.ConclusionsThe present study identifies preoperative intra-tumoral hemorrhage as an indicator variable for poor prognosis in patients with BM undergoing neurosurgical treatment.

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“…It appears likely that parameters that better reflect multimorbidity or frailty like the Hurria [ 49 ] or G8 score [ 50 ] may aid in prognostic assessment in BM patients. Further, it would be interesting to validate temporal muscle thickness, which appears to be a relevant independent prognostic parameter in patients with BM, [ 51 , 52 ] in LTS.…”

Section: Discussionmentioning

confidence: 99%

Long-term survival in patients with brain metastases—clinical characterization of a rare scenario

Hügel,

Stöhr,

Kuhnt

et al. 2023

Strahlenther Onkol

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Purpose This study aimed to assess clinical, treatment, and prognostic features in patients with brain metastases (BM) from solid tumors achieving long-term survival (LTS). Further, the accuracy of diagnosis-specific Graded Prognostic Assessment scores (ds-GPA) to predict LTS was evaluated. Methods Patients admitted for radiotherapy of BM between 2010 and 2020 at a large tertiary cancer center with survival of at least 3 years from diagnosis of BM were included. Patient, tumor, treatment characteristics and ds-GPA were compiled retrospectively. Results From a total of 1248 patients with BM, 61 (4.9%) survived ≥ 3 years. In 40 patients, detailed patient charts were available. Among LTS patients, median survival time from diagnosis of BM was 51.5 months. Most frequent primary tumors were lung cancer (45%), melanoma (20%), and breast cancer (17.5%). At the time of diagnosis of BM, 11/40 patients (27.5%) had oligometastatic disease. Estimated mean survival time based on ds-GPA was 19.7 months (in 8 cases estimated survival < 12 months). Resection followed by focal or whole-brain radiotherapy (WBRT) was often applied (60%), followed by primary stereotactic radiotherapy (SRT) (20%) or WBRT (20%). 80% of patients received systemic treatment, appearing particularly active in specifically altered non-small lung cancer (NSCLC), melanoma, and HER2-positive breast cancer. Karnofsky performance score (KPS) and the presence of oligometastatic disease at BM diagnosis were persisting prognostic factors in LTS patients. Conclusion In this monocentric setting reflecting daily pattern of care, LTS with BM is heterogeneous and difficult to predict. Effective local treatment and modern systemic therapies often appear crucial for LTS. The impact of concomitant diseases and frailty is not clear.

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Combined Assessment of Preoperative Frailty and Sarcopenia Allows the Prediction of Overall Survival in Patients with Lung Cancer (NSCLC) and Surgically Treated Brain Metastasis

Cited by 24 publications

References 31 publications

Temporal Muscle and Stroke—A Narrative Review on Current Meaning and Clinical Applications of Temporal Muscle Thickness, Area, and Volume

Temporal Muscle and Stroke—A Narrative Review on Current Meaning and Clinical Applications of Temporal Muscle Thickness, Area, and Volume

Preoperative Metastatic Brain Tumor-Associated Intracerebral Hemorrhage Is Associated With Dismal Prognosis

Long-term survival in patients with brain metastases—clinical characterization of a rare scenario

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