Combined approach of FTIR imaging and conventional dissolution tests applied to drug release

Weerd, Jaap van der; Kazarian, Sergei G.

doi:10.1016/j.jconrel.2004.05.007

Cited by 101 publications

(60 citation statements)

References 11 publications

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“…Nevertheless, it is clear that the boundaries observed in photography are sharp, unlike the fluent gradients obtained from mathematical simulation based on Fick's laws [19][20][21] and the results of FTIR spectroscopic imaging [12,13,15,17,22]. This can be attributed to the fact that photography does not provide a quantitative value for the concentration of the different materials.…”

Section: Time Resolution Specificitymentioning

confidence: 87%

“…Surface sensitive [10,11] ATR-FTIR imaging Quantitative Surface sensitive [12][13][14][15][16][17] Transmission-FTIR imaging Quantitative Unrealistic tablet needed (thickness <20µm) [18] An advantage of MRI is the ease of sampling. A slice or line can be selected in a tablet completely immersed in the dissolution fluid, as MRI is a 3D technique.…”

Section: Time Resolution Specificitymentioning

confidence: 99%

“…These channels can be connected to ordinary tubing. ATR-FTIR spectra are acquired as described previously [17], while optical images can be acquired simultaneously through the window using a CCD camera (indicated as a TV camera in the Fig. 1).…”

Section: Cell Design Considerationsmentioning

confidence: 99%

“…The set-up can be used as a flow-through dissolution test by determining the amount of drug in the solution after contact with the tablet [17]. This is possible by any flowthrough detector, such as the detectors used in high pressure liquid chromatography.…”

Section: Cell Design Considerationsmentioning

confidence: 99%

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Simultaneous FTIR Spectroscopic Imaging and Visible Photography to Monitor Tablet Dissolution and Drug Release

Kazarian

Weerd

2007

Pharm Res

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A method to study tablet dissolution simultaneously by Fourier transform infraredattenuated total reflection (FTIR-ATR) imaging and macro-photography is described. Such a combined approach appeared important as the results of macro-photography, which have been provided by a number of authors, led to contradictory interpretations. The macro-photographs of a pharmaceutical tablet during exposure to water show a number of 'fronts' moving into the tablet. These fronts are obviously related to water penetration into and dissolution of the tablet, but the exact nature can not be derived from photographic evidence. Therefore, the combination of macro-photography and FTIR-ATR imaging was developed and used to interpret the physical changes leading to the observed fronts. The quantitative results obtained by FTIR-ATR imaging enabled the attribution of the three observed fronts (inside to outside) to: 1. True water penetration, possibly combined with (partial) dissolution of buflomedyl pyridoxal phosphate (BPP) 2. Total gellification of hydroxypropyl-methylcellulose (HPMC) 3. Erosion front IntroductionIn recent years, a number of new approaches has been reported to study the behaviour of pharmaceutical tablets during dissolution. These studies aim to generate an understanding of the processes in a dissolving tablet. This is a welcome addition to the standard dissolution tests, which obtain the amount of dissolved active ingredient as a function of time, but do not provide indications on the underlying mechanisms of tablet dissolution.

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Section: Time Resolution Specificitymentioning

confidence: 87%

Section: Time Resolution Specificitymentioning

confidence: 99%

Section: Cell Design Considerationsmentioning

confidence: 99%

Section: Cell Design Considerationsmentioning

confidence: 99%

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Simultaneous FTIR Spectroscopic Imaging and Visible Photography to Monitor Tablet Dissolution and Drug Release

Kazarian

Weerd

2007

Pharm Res

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“…FT-IR imaging of PEG dissolution in an aqueous environment has been implemented to investigate the drug release mechanism [12][13][14][15]. While this method provides chemical selectivity, the long excitation wavelength used in FT-IR microscopy offers the spatial resolution of several to tens micrometer, which does not allow the visualization of 3D distribution of drug molecules in thin polymer films or microparticles.…”

Section: Introductionmentioning

confidence: 99%

Paclitaxel distribution in poly(ethylene glycol)/poly(lactide-co-glycolic acid) blends and its release visualized by coherent anti-Stokes Raman scattering microscopy

Kang¹,

Robinson²,

Park³

et al. 2007

Journal of Controlled Release

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Mechanisms underlying the release of paclitaxel (PTX) from poly(ethylene glycol)/poly(lactic-coglycolic acid) (PEG/PLGA) blends were investigated by coherent anti-Stokes Raman scattering (CARS) microscopy. PLGA, PEG, and PTX were selectively imaged by using the resonant CARS signal from the CH 3 , CH 2 , and aromatic CH stretch vibrations, respectively. Phase segregation was observed in PLGA films containing 10 to 40 wt.% PEG in the absence of PTX loading. The PEG phase existed in the form of crystalline fibers in the (8:2, weight ratio) and (7:3) PLGA/PEG films. CARS observation indicated that PTX preferentially partitioned into the PEG domains in the (9:1) and (8:2) PLGA/PTX films, but exhibited a uniform mixing with both PLGA and PEG in the (7:3) PLGA/PEG film. The solid dispersion of PTX into PEG domains was attributed to a strong interaction between PTX and PEG, supported by the disappearance of PEG crystallization in the PTX-loaded PLGA/PEG film evidenced through X-ray diffraction analysis. PTX release was induced by exposing the film to an aqueous solution and monitored in real time by CARS and two-photon fluorescence microscopy. Fast dissolution of both PEG and PTX was observed at the film surface. Upon infiltration of water into the film, the PEG domains rearranged into ring structures enriched by both PTX and PEG. The CARS data provided a visual evidence explaining the accelerated burst release followed by more sustained release of PTX from the PLGA/PEG films as measured by HPLC.

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Applications of FTIR Spectroscopic Imaging in Pharmaceutical Science

Kazarian

Wray

2010

Raman, Infrared, and Near‐Infrared Chemical Imaging

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Combined approach of FTIR imaging and conventional dissolution tests applied to drug release

Cited by 101 publications

References 11 publications

Simultaneous FTIR Spectroscopic Imaging and Visible Photography to Monitor Tablet Dissolution and Drug Release

Simultaneous FTIR Spectroscopic Imaging and Visible Photography to Monitor Tablet Dissolution and Drug Release

Paclitaxel distribution in poly(ethylene glycol)/poly(lactide-co-glycolic acid) blends and its release visualized by coherent anti-Stokes Raman scattering microscopy

Applications of FTIR Spectroscopic Imaging in Pharmaceutical Science

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