Combined application of simulated reuse and quantitative carrier tests to assess high-level disinfection: Experiments with an accelerated hydrogen peroxide-based formulation

Sattar, Syed A.; Adegbunrin, Olusola; Ramírez, José Antonio

doi:10.1067/mic.2002.126428

Cited by 23 publications

(13 citation statements)

References 3 publications

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“…Taking into account the biocidal efficacy of disinfectants, as well as security to users and the environment and compatibility with disinfected materials, a new formulation based on hydrogen peroxide (accelerated hydrogen peroxide, AHD) was developed [18,19]. It contains very low levels of certain food-grade anionic and non-ionic surfactants, which act in synergy with hydrogen peroxide to produce the desired microbicidal activity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of mycobactericidal activity of selected chemical disinfectants and antiseptics according to European standards

2014

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BackgroundThe history of the investigation of standardized mycobactericidal activity of disinfectants and antiseptics is not very long. There is growing interest among the manufacturers of disinfectants in carrying out research on the antimicrobial activities in accordance with European standards (EN). This research could facilitate the introduction of high-quality disinfectants to the market. The aim of this study was to evaluate the mycobactericidal activity of selected chemical disinfectants and antiseptics used in the medical and veterinary fields.Material/MethodsThis study included 19 products submitted to the National Medicines Institute in Poland for evaluation of mycobactericidal activity. These products contain in their composition active substances belonging to different chemical groups, including aldehydes, alcohols, amines, quaternary ammonium compounds, phenols, guanidine, and oxidizing compounds. This study, conducted according to the manufacturers’ description of the preparations, was carried out in accordance with European standards, which also met the Polish standards: PN-EN 14204: 2013, PN-EN 14348: 2006, and PN-EN 14563: 2012.ResultsTested products for disinfection and antiseptics containing active substances from different chemical groups showed high mycobactericidal activity and met the requirements of the appropriate European standards in most cases. In the case of products containing guanidine and amine compounds, the concentration of active ingredients used in the test and the test conditions specified by the manufacturer did not provide the mycobactericidal activity required by the standards.ConclusionsPrior to the launch of a new product on the market, it is important to establish the appropriate usage and testing conditions of the preparation, such as its practical concentration, contact time, and environment condition (clean or dirty).

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Section: Discussionmentioning

confidence: 99%

Evaluation of mycobactericidal activity of selected chemical disinfectants and antiseptics according to European standards

2014

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“…It was reported that all chlorine-based disinfectants were significantly more effective in killing bacteria and fungi in 5 min and the efficiency was generally increased when the contact time was prolonged from 5 to 15 min (Van Klingeren et al, 1998;Özalp et al, 2007;Salo and Wirtanen, 2005). Other groups reported that 3-25% hydrogen peroxide was able to inactivate bacteria and fungi by > 6 log 10 reduction in a contact time of 5 min, while, Sanipine and Sanismel were effective only at 1:15 for 30 min requiring prolonged exposure time or greater concentration (Russell, 1998;Alfa and Jackson, 2001;Sattar et al, 2002). Quaternary ammonium compounds gained popularity due to its good antibacterial and antifungal at relatively low concentration within shorter contact time (Russell, 1998;Fraise, 1999).…”

Section: Discussionmentioning

confidence: 99%

Quantitative suspension tests for the evaluation of bactericidal, fungicidal and sporicidal effects of biocides used in vaccine production facility

Sheraba¹,

Yassin²,

Fahmy³

et al. 2014

Afr. J. Microbiol. Res.

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The appropriate use of biocides is essential in any vaccine production facility and their proper evaluation using standardized tests marks the first step to ensure their proper use. Quantitative suspension tests against reference and environmental isolates were carried out to evaluate the efficacy of various biocides used in the main vaccine production facility in Egypt. Several use-dilutions of the biocides were evaluated at contact times of up to 5 min in case of antiseptics and 30 min in case of disinfectants to measure the biocide activity against bacteria, fungi and spores. Standard strains were used in addition to the main bacterial isolates identified in an environmental monitoring program carried out in the same facility. Alcohol based biocides showed bactericidal and fungicidal activity but no sporicidal activity. Chlorine based compounds and glutaraldehyde showed bactericidal and fungicidal effect while, the sporicidal effects depended on the used dilution and the contact time. Hydrogen peroxide showed bactericidal, fungicidal and sporicidal activity. Quaternary ammonium compounds tested showed very weak activity in all tests. Evaluation of the biocide is an essential step to guarantee the use of the most appropriate agent in any location.

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“…Pinheiro (1990), portanto, concluiu que experimentos visando o aperfeiçoamento do método microbiológico convencional para um rápido diagnóstico representam uma grande vantagem na luta contra a tuberculose no homem e nos animais (SCHABERG et. al.…”

Section: Panamericano De Zoonosis 1979) (Anexo A)unclassified

“…Requer estufas incubadoras, meios de cultura, autoclaves para preparação e descontaminação dos materiais utilizados e exige recurso humano mais qualificado, uma vez que o risco de infecção quando se trabalha com culturas de bactérias patogênicas são maiores. Entretanto, esta técnica é muito mais acessível aos laboratórios com menos recursos (principalmente nos paises em desenvolvimento) e aos médicos veterinários do que as modernas técnicas radiométricas e métodos envolvendo engenharia molecular, como a reação em cadeia da polimerase (PCR), dado o alto custo dos equipamentos para esses exames (SCHABERG et al, 1995;MEJIA et al, 1999 KONEMAN et al, 1993;IDIGORAS et al, 1995).…”

Section: Introdução 1 Introduçãounclassified

“…O aperfeiçoamento do método microbiológico convencional para um rápido diagnóstico representa uma grande vantagem na luta contra a tuberculose no homem e no bovino (SCHABERG et al, 1995;MEJIA et al, 1999). Além disso, permitiria a realização de avaliações da atividade de produtos químicos frente a micobactérias patogênicas em um período de tempo mais curto, influenciando diretamente na velocidade das ações profiláticas e sanitárias dos programas de controle da tuberculose.…”

Section: Introdução 1 Introduçãounclassified

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Avaliação da atividade micobactericida de desinfetantes químicos utilizando a técnica de cultivo em camada de ágar Middlebrook 7H11

Morato¹

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Combined application of simulated reuse and quantitative carrier tests to assess high-level disinfection: Experiments with an accelerated hydrogen peroxide-based formulation

Cited by 23 publications

References 3 publications

Evaluation of mycobactericidal activity of selected chemical disinfectants and antiseptics according to European standards

Evaluation of mycobactericidal activity of selected chemical disinfectants and antiseptics according to European standards

Quantitative suspension tests for the evaluation of bactericidal, fungicidal and sporicidal effects of biocides used in vaccine production facility

Avaliação da atividade micobactericida de desinfetantes químicos utilizando a técnica de cultivo em camada de ágar Middlebrook 7H11

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