Combined application of neural stem/progenitor cells and scaffolds on locomotion recovery following spinal cord injury in rodents: a systematic review and meta-analysis

Yousefifard, Mahmoud; Askarian‐Amiri, Shaghayegh; Maleki, Solmaz Nasseri; Alavi, Seyedeh Niloufar Rafiei; Neishaboori, Arian Madani; Haghani, Leila; Vaccaro, Alexander R.; Lu, Yi; Rahimi‐Movaghar, Vafa; Hosseini, Mostafa

doi:10.1007/s10143-022-01859-4

Cited by 4 publications

(1 citation statement)

References 79 publications

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“…In order to achieve the ideal recovery effect of cell transplantation therapy, the emergence of scaffolds has enriched the treatment of cell transplantation. At present, the curative effects of SCI may not be significantly improved through single-cell transplantation, which may be associated with the survival of transplanted cells, directional migration to the lesion site, differentiation, and axonal regeneration of transplanted cells (Yousefifard et al 2022 ; Yousefifard et al 2019 ). Comprehensive cell transplantation therapy combined with tissue engineering scaffolds became a trend.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis

Wang,

Li,

et al. 2024

Cell Mol Neurobiol

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Cell transplantation is a promising treatment option for spinal cord injury (SCI). However, there is no consensus on the choice of carrier scaffolds to host the cells. This study aims to evaluate the efficacy of different material scaffold-mediated cell transplantation in treating SCI in rats. According to PRISMA’s principle, Embase, PubMed, Web of Science, and Cochrane databases were searched, and relevant literature was referenced. Only original research on cell transplantation plus natural or synthetic scaffolds in SCI rats was included. Direct and indirect evidence for improving hind limb motor function was pooled through meta-analysis. A subgroup analysis of some factors that may affect the therapeutic effect was conducted to understand the results fully. In total, 25 studies met the inclusion criteria, in which 293 rats received sham surgery, 78 rats received synthetic material scaffolds, and 219 rats received natural materials scaffolds. The network meta-analysis demonstrated that although synthetic scaffolds were slightly inferior to natural scaffolds in terms of restoring motor function in cell transplantation of SCI rats, no statistical differences were observed between the two (MD: −0.35; 95% CI −2.6 to 1.9). Moreover, the subgroup analysis revealed that the type and number of cells may be important factors in therapeutic efficacy (P < 0.01). Natural scaffolds and synthetic scaffolds are equally effective in cell transplantation of SCI rats without significant differences. In the future, the findings need to be validated in multicenter, large-scale, randomized controlled trials in clinical practice. Trial registration: Registration ID CRD42024459674 (PROSPERO). Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis

Wang,

Li,

et al. 2024

Cell Mol Neurobiol

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Efficacy of growth factor gene–modified stem cells for motor function after spinal cord injury in rodents: a systematic review and meta‑analysis

Shang,

Ren,

et al. 2024

Neurosurg Rev

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Neural Stem Cells in Tissue Engineering

Zhang,

Gao,

Chen

et al. 2024

Stem Cells in Clinical Application and Productization

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Neural stem cells (NSCs) are unique subsets of stem cells with self-renewal and multiple lineage differentiation potential, which are considered promising cell sources for neuron generation and complex cognitive and sensory functions, and the resultant NSC-based cryotherapy for regenerative purposes. Of them, distinguished from the small amount of activated subset, most of the NSCs are maintained in the quiescent state and reveal a low level of metabolic activity but a high sensitivity to the environment. The dynamic balance between quiescence and the activity of NSCs determines both the efficiency of neurogenesis and the long-term maintenance and self-renewal of the NSC pool as well as the neurogenic capacity of the brain. In this chapter, we mainly review the classification and biofunction of NSCs, and introduce the significant progress in the understanding of NSC-based applications and the underlying molecular mechanism for NSC quiescence, the dysfunction in neurogenesis, and the pathogenesis of neurological disorders. Collectively, these data will facilitate the development of NSC-based cytotherapy for a broad spectrum of refractory and recurrent diseases in the future.

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Combined application of neural stem/progenitor cells and scaffolds on locomotion recovery following spinal cord injury in rodents: a systematic review and meta-analysis

Cited by 4 publications

References 79 publications

The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis

The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis

Efficacy of growth factor gene–modified stem cells for motor function after spinal cord injury in rodents: a systematic review and meta‑analysis

Neural Stem Cells in Tissue Engineering

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