Combined Antihypertensive Therapy and Sexual Dysfunction: Terra Incognita

Doumas, Michael; Viigimaa, Margus; Papademetriou, Vasilios

doi:10.1159/000351696

Cited by 15 publications

(8 citation statements)

References 36 publications

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“…The findings of existing studies are contradictory. Older antihypertensive drugs (diuretics, beta-blockers, centrally acting agents) have been shown to have a negative impact on erectile function, while newer agents have been shown to have either neutral (ACE inhibitors, calcium antagonists) or beneficial effects (angiotensin receptor blockers, nebivolol) [22][23][24][25][26][27][28][29][30][31][32][33][34][35]: contrasting findings have been described by Erdmann [36] who states that erectile dysfunction is no more common with beta-blockers than with any other drug prescribed for chronic heart failure or hypertension. Similar conclusions are also reached by Ko et al [37].…”

Section: Discussionmentioning

confidence: 99%

Sexual Dysfunction Related to Drugs: A Critical Review. Part IV: Cardiovascular Drugs

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Sexual Dysfunction Related to Drugs: A Critical Review. Part IV: Cardiovascular Drugs

et al. 2014

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“…Data regarding the effects of antihypertensive drug therapy on ED are limited, usually address monotherapy only, and come mainly from observational studies. Data from randomized studies addressing combination therapy are urgently needed [34,35]. To date, ED has never been defined as a primary endpoint in any large clinical trial of antihypertensive drugs.…”

Section: Effects Of Antihypertensive Drugs On Erectile Functionmentioning

confidence: 99%

“…Diuretics are also believed to impair ED, even when used in combined antihypertensive therapy [35]. The type and dosage of the diuretic may be of importance.…”

Section: Effects Of Antihypertensive Drugs On Erectile Functionmentioning

confidence: 99%

Hypertension and Reproduction

et al. 2020

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Purpose of Review Many aspects of reproduction have been associated with increased blood pressure and impaired glucose metabolism that reveals a subsequent increased risk of cardiovascular disease. The aim of this review is to assess reproductive life factors associated with an increased risk of hypertension and cardiovascular disease, e.g., early life programming, sexual, and reproductive health in men and women. Recent Findings Impaired fetal growth, with low birth weight adjusted for gestational age, has been found associated with hypertension in adulthood. Erectile dysfunction, currently considered an early diagnostic marker of cardiovascular disease preceding the manifestation of coronary artery disease by several years, frequently coexisting with hypertension, could also be exacerbated by some antihypertensive drugs. Male hypogonadism or subfertility are associated with increased cardiovascular risk. Hypertensive disorders in pregnancy including preeclampsia represent a major cause of maternal, fetal and neonatal morbidity, and mortality. The risk of developing preeclampsia can be substantially reduced in women at its high or moderate risk with a low dose of acetylsalicylic acid initiated from 12 weeks of gestation. An increased risk of hypertension in women following invasive-assisted reproductive technologies has been newly observed. Blood pressure elevation has been noticed following contraceptive pill use, around the menopause and in postmenopausal age. Furthermore, drug treatment of hypertension has to be considered as a factor with a potential impact on reproduction (e.g., due to teratogenic drug effects). Summary In summary, a deeper understanding of reproductive life effects on hypertension and metabolic abnormalities may improve prediction of future cardiovascular disease.

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“…The increased prevalence of erectile dysfunction in arterial hypertension and other cardiovascular disease conditions raises the question whether erectile dysfunction is the result of high blood pressure and atherosclerosis or antihypertensive drugs contribute to the appearance of erectile dysfunction [35][36][37][38]. Accumulating evidence indicates that hypertension per se results in structural and functional abnormalities of the penile tissue and subsequent erectile dysfunction [3,6].…”

Section: Antihypertensive Drugs and Erectile Dysfunctionmentioning

confidence: 99%

Erectile Function in Cardiovascular Disease and Hypertension: the Role of Nebivolol

Manolis¹,

Doumas²

2016

J Hypertens (Los Angel)

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Beta blockers are used for the management of arterial hypertension and are gold standard treatment for coronary artery disease and heart failure, medical conditions that affect large numbers of older patients and are associated with very high morbidity and mortality rates.Lifelong therapy in primary and secondary prevention (without and with established cardiovascular disease, respectively) is limited by low adherence to drugs which is accompanied by increased mortality. Drug adverse events and impaired quality of life are among the main causes of poor adherence to therapy. Erectile dysfunction is the 'prima ballerina' of drug-induced life quality impairment. Beta blockers exert detrimental effects on erectile function. In contrast, nebivolol (a third generation beta blocker with vasodilating properties and proven efficacy in patients with hypertension and heart failure) does not share the unfavourable effects of other beta blockers on erectile function due to increased nitric oxide bioavailability.Therefore, Nebivolol represents an attractive option for patients with hypertension, heart failure, and other related diseases who need to be treated with beta blockers.

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Combined Antihypertensive Therapy and Sexual Dysfunction: Terra Incognita

Cited by 15 publications

References 36 publications

Sexual Dysfunction Related to Drugs: A Critical Review. Part IV: Cardiovascular Drugs

Sexual Dysfunction Related to Drugs: A Critical Review. Part IV: Cardiovascular Drugs

Hypertension and Reproduction

Erectile Function in Cardiovascular Disease and Hypertension: the Role of Nebivolol

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