Combined anti-solvent and cooling method of manufacturing indomethacin–saccharin (IMC–SAC) co-crystal powders

Chun, Nan-Hee; Lee, Min-Jeong; Song, Geon-Hyung; Chang, Kwan-Young; Kim, Chang-Sam; Choi, Guang J.

doi:10.1016/j.jcrysgro.2014.07.057

Cited by 29 publications

(21 citation statements)

References 18 publications

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“…The yield was further augmented by introducing cooling into the system: the timing of the cooling influenced the formation of the cocrystals. The metastable α-indomethacin formed only when the cooling was applied before the nucleation [124].…”

Section: Conventional Methodsmentioning

confidence: 99%

Production of pure drug nanocrystals and nano co-crystals by confinement methods

Fontana

Figueiredo

Zhang

et al. 2018

Advanced Drug Delivery Reviews

127

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The use of drug nanocrystals in the drug formulation is increasing due to the large number of poorly water-soluble drug compounds synthetized and due to the advantages brought by the nanonization process. The downsizing processes are done using a top-down approach (milling and homogenization currently employed at the industrial level), while the crystallization process is performed by bottom-up techniques (e.g., antisolvent precipitation, use of supercritical fluids or spray and freeze drying). In addition, the production of nanocrystals in confined environment can be achieved within microfluidics channels. This review analyzes the processes for the preparation of nanocrystals and co-crystals, divided by top-down and bottom-up approaches, together with their combinations. The combination of both strategies merges the favorable features of each process and avoids the disadvantages of single processes. Overall, the applicability of drug nanocrystals is highlighted by the widespread research on the production processes at the engineering, pharmaceutical, and nanotechnology level.

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Section: Conventional Methodsmentioning

confidence: 99%

Production of pure drug nanocrystals and nano co-crystals by confinement methods

Fontana

Figueiredo

Zhang

et al. 2018

Advanced Drug Delivery Reviews

127

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“…A suitable type of solvent is used in solution method for the preparation of cocrystals. Different types of solution methods such as solvent evaporation [76] , solution crystallization technique [41] , antisolvent addition [82] , slurry conversion method [83] and reaction crystallization method [84] are discussed with suitable examples. Grinding methods are of two types: neat grinding and solvent drop grinding [85,86] .…”

Section: Differnt Methods Of Cocrystals Formationmentioning

confidence: 99%

“…This solution is then added to distilled water or suitable solution to precipitate the coformer on the drug [82,98,99] .…”

Section: Solution-based Methodsmentioning

confidence: 99%

Pharmaceutical Cocrystals: An Overview

Kumar¹,

Nanda²

2017

pharmaceutical-sciences

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“…This technique mainly includes: Solvent evaporation [12], solvent drop grinding [13], liquid-assisted grinding [14], solution crystallization [15], cooling crystallization [16], supercritical fluids [17], slurry method [18], antisolvent method [19], reaction crystallization method [20], ultrasound-assisted solution technique [21], supercritical fluid atomization techniques [22], and spray drying techniques [23].…”

Section: Liquid-based Techniquementioning

confidence: 99%

Cocrystals: A Complete Review on Conventional and Novel Methods of Its Formation and Its Evaluation

Yadav

Khursheed

Singh

2019

Asian J Pharm Clin Res

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The active moiety with poor solubility is posing a challenge in drug development which may reduce the effectiveness in patients when administered orally. Cocrystal formation is one of the latest approaches for improving the various parameters of a drug molecule such as solubility, melting point, pharmacokinetic, pharmacodynamic, and bioavailability. Cocrystals are crystalline single state materials composed of two or more than two different molecular amalgams held together in a fixed stoichiometric ratio. There are various techniques used for the preparation of cocrystals such as solvent evaporation, grinding, and cooling crystallization. The quantitative and qualitative aspects of these cocrystals are evaluated using various validated instruments such as nuclear magnetic resonance, powder X-ray diffraction, and differential scanning calorimetry.

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Combined anti-solvent and cooling method of manufacturing indomethacin–saccharin (IMC–SAC) co-crystal powders

Cited by 29 publications

References 18 publications

Production of pure drug nanocrystals and nano co-crystals by confinement methods

Production of pure drug nanocrystals and nano co-crystals by confinement methods

Pharmaceutical Cocrystals: An Overview

Cocrystals: A Complete Review on Conventional and Novel Methods of Its Formation and Its Evaluation

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