Combined androgen blockade therapy can convert RT-PCR detection of prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA) transcripts from positive to negative in the peripheral blood of patients with clinically localized prostate cancer and increase biochemical failure-free survival after curative therapy

Lembessis, Peter; Msaouel, Pavlos; Halapas, Antonios; Sourla, Antigone; Panteleakou, Zacharoula; Pissimissis, Nikolaos; Milathianakis, Constantine; Bogdanos, John; Papaioannou, Andreas; Maragoudakis, E; Dardoufas, C.; Dimopoulos, Theodoros; Koutsilieris, Michael

doi:10.1515/cclm.2007.301

Cited by 23 publications

(11 citation statements)

References 39 publications

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“…Notably, in the present meta-analysis, we have extracted merely the data at baseline as the timing of the assessment. Indeed, too many confounders exist during treatment: different therapeutic options; transient dissemination of CTC during the surgical and invasive procedure 75 76 ; destruction or conversion of CTC induced by chemotherapy 77 . The diagnostic accuracy and prognostic value of CTC therefore should only be interpreted for the initial evaluation of tumor burdens.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Value of Circulating Tumor Cells in Head and Neck Squamous Cell Carcinoma: a systematic review and meta-analysis

Fauré

et al. 2016

Sci Rep

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Several techniques have been developed to detect circulating tumor cells (CTC) in patients with head and neck squamous cell carcinoma (HNSCC), but their diagnostic and prognostic value are not yet fully established. A computerized retrieval of literatures was conducted without time restrictions using the electronic database in December 2014. Diagnostic accuracy variables were pooled and analyzed by the Meta-DiSc software. Engauge Digitizer and Stata software were used for pooled survival analysis. Twenty-two retrieved studies were eligible for systematic review, of which 9 conformed for the diagnostic test meta-analysis and 5 for the prognostic analysis. Subgroup analysis showed 24.6% pooled sensitivity and 100% pooled specificity of detections by using positive selection strategy, which moreover presented low heterogeneity. The presence of CTC was significantly associated with shorter disease free survival (DFS, HR 4.62, 95% CI 2.51–8.52). In conclusion, current evidence identifies the CTC detection assay as an extremely specific, but low sensitive test in HNSCC. Also, the presence of CTC indicates a worse DFS.

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Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Value of Circulating Tumor Cells in Head and Neck Squamous Cell Carcinoma: a systematic review and meta-analysis

Fauré

et al. 2016

Sci Rep

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“…An important aspect in CTC detection is the timing of the assessment because it has been suggested that surgical interventions may cause transient dissemination of CTCs in the bloodstream [55,56] whereas chemotherapy and other systemic treatments may destroy CTCs or downregulate marker expression and thus convert CTC+ patients to CTC- [57]. Our findings suggest that nontreated patients or patients who were assessed ≥7 days after the last treatment were less likely to have detectable bladder/urothelial CTCs in their bloodstream.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of circulating tumor cell detection in bladder and urothelial cancer: systematic review and meta-analysis

Msaouel

Koutsilieris

2011

BMC Cancer

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BackgroundThe diagnostic value and prognostic significance of circulating tumor cell (CTC) detection in patients with bladder cancer is controversial. We performed a meta-analysis to consolidate current evidence regarding the use of CTC detection assays to diagnose bladder and other urothelial cancers and the association of CTC positivity with advanced, remote disease.MethodsStudies that investigated the presence of CTCs in the peripheral blood of patients with bladder cancer and/or urothelial cancer were identified and reviewed. Sensitivities, specificities, and positive (LR+) and negative likelihood ratios (LR-) of CTC detection in individual studies were calculated and meta-analyzed by random effects model. Overall odds ratio of CTC positivity in patients with advanced disease versus those with organ-confined cancer was also calculated.ResultsOverall sensitivity of CTC detection assays was 35.1% (95%CI, 32.4-38%); specificity, LR+, and LR- was 89.4% (95%CI, 87.2-91.3%), 3.77 (95%CI, 1.95-7.30) and 0.72 (95%CI, 0.64-0.81). CTC-positive patients were significantly more likely to have advanced (stage III-IV) disease compared with CTC-negative patients (OR, 5.05; 95%CI, 2.49-10.26).ConclusionsCTC evaluation can confirm tumor diagnosis and identify patients with advanced bladder cancer. However, due to the low overall sensitivity, CTC detection assays should not be used as initial screening tests.

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“…Recent studies have revealed that the EMT phenotype in CTCs may facilitate tumor metastasis. Characterizing the epithelial versus mesenchymal phenotypes of CTCs may be useful to identify the most aggressive CTC subpopulations and establish an appropriate therapy (Zehentner et al, 2006;Lembessis et al, 2007;Tsouma et al, 2008;Theodoropoulos et al, 2010;Yu et al, 2013;Okabe et al, 2014;Satelli et al, 2015;Zhao et al, 2019). Because of the aggressiveness and mortality of metastatic melanoma cancer, it has become increasingly urgent to define novel diagnostic melanoma biomarkers that can be useful to predict an increased risk of metastasis at an early stage.…”

Section: Introductionmentioning

confidence: 99%

Stem–Mesenchymal Signature Cell Genes Detected in Heterogeneous Circulating Melanoma Cells Correlate With Disease Stage in Melanoma Patients

Rapanotti

Campione

Viguria

et al. 2020

Front. Mol. Biosci.

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During the process of metastasis, cancer cells dissociate from primary tumors, migrate to distal sites, and finally colonize, eventually leading to the formation of metastatic tumors. These cancer cells, defined circulating tumor cells (CTCs) spreading through the blood stream, may develop metastatic lesions or remain dormant. Some emerging clinical evidence supports that some tumor cells may possess metastatic properties already in the earlier stages of tumorigenesis. Because the initiation and progression of vertical growth in human melanoma is fundamental to the notion of tumor virulence and progression, we decided to immune-magnetic collect and molecularly characterize circulating melanoma cells (CMCs) from melanoma patients AJCC staged = pT1b (i.e., transition from radial to vertical phase). CMCs are phenotypically and molecularly heterogeneous, thus we performed a "home-made Liquid-Biopsy," by targeting the melanoma-associated-antigen, MCAM/MUC18/CD146, and/or the melanoma-initiating marker, ABCB5. We assessed a biomarker qualitative expression panel, contemplating the angiogenic-potential, melanoma-initiating and melanoma-differentiation drivers, cellcell adhesion molecules, matrix-metallo-proteinases, which was performed on three enriched subpopulations from a total of 61 blood-samples from 21 melanoma patients. At first, a significant differential expression of the specific transcripts was documented between and within the CMC fractions enriched with MCAM-, ABCB5-, and both MCAM/ABCB5-coated beads, when analyzing two distinct groups: early AJCC-(stage I-II) and advanced-staged patients (stage II-IV). Moreover, in the early-AJCC stagedgroup, we could distinguish "endothelial," CD45 − MCAM + enriched-, "stem" S-CMCs, CD45 − ABCB5 + enriched-and a third hybrid bi-phenotypic CD45 − MCAM + /ABCB5 + enriched-fractions, due to three distinct gene-expression profiles. In particular, the endothelial-CMCs were characterized by positive expression of genes involved in

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Cited by 23 publications

References 39 publications

Diagnostic and Prognostic Value of Circulating Tumor Cells in Head and Neck Squamous Cell Carcinoma: a systematic review and meta-analysis

Diagnostic and Prognostic Value of Circulating Tumor Cells in Head and Neck Squamous Cell Carcinoma: a systematic review and meta-analysis

Diagnostic value of circulating tumor cell detection in bladder and urothelial cancer: systematic review and meta-analysis

Stem–Mesenchymal Signature Cell Genes Detected in Heterogeneous Circulating Melanoma Cells Correlate With Disease Stage in Melanoma Patients

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