Combined analysis of miRNA‐181a with phase angle derived from bioelectrical impedance predicts radiotherapy‐induced changes in body composition and survival of male patients with head and neck cancer

Abstract

Background Nutritional deficits developing as an effect of applied radiotherapy (RTH) negatively affect patients' quality of life, survival, and therapy outcomes. We demonstrated novel approach to prediction of RTH‐induced changes in body composition of patients with head and neck cancer using phase angle (PA) derived from bioelectrical impedance in combination with miRNA‐181a expression. Results Patients with simultaneous presence of low PA and high miRNA expression were at a significantly higher risk of decreasing the fat‐free mass index (FFMI) <14.9 kg/m2 (odds ratio [OR] = 5.14; P = .02), FFM < 44.7 kg (OR = 6.20; P = .04), and lean mass (OR = 10.0; P = .04) during the therapy period. Receiver operating curve analysis allowed to predict changes in FFMI, lean mass, and FFM with area under the curve calculation over 0.700. The simultaneous presence of high miRNA and low PA negatively affected patients' survival (OR = 5.12; P = .02). Conclusion Evaluation of PA in combination with miRNA demonstrates higher diagnostic accuracy and predictive value for detecting RTH‐induced changes in body composition of patients with cancer.

Predicational ability of phase angle on protein energy wasting in kidney disease patients with renal replacement therapy: A cross‐sectional study

“…Phase angle ( R = .516, p < .01), BMI ( R = .466, p < .01), and waist circumference ( R = .889, p < .01) were positively correlated with MAC, while albumin ( R = −.426, p < .01) and EW/TBW ( R = −0.357, p < .004) were negatively correlated with MAC, respectively (Krishnamoorthy et al., 2015; Tan et al., 2019). Considering M‐BIA as predictor in the evaluation of health in populations (Norman et al., 2012; Powrózek et al., 2019; Vermeulen, Lopes, Alves et al., 2019), our result also indicated that PA can be used as independent factor associated with malnutrition in CKD patients.…”

“…Considering M-BIA as predictor in the evaluation of health in populations (Norman et al, 2012;Powrózek et al, 2019;, our result also indicated that PA can be used as independent factor associated with malnutrition in CKD patients. Karavetian et al (2019)…”

“…Yoshida's study indicated that patients with severe motor and intellectual disabilities have lower PA value and ECW/TBW (Yoshida et al., 2017). Besides PA, MAC and body composition also could be used as the indicators for PEW diagnosis in RRT patients (Krishnamoorthy et al., 2015; Leal Escobar et al., 2019; Powrózek et al., 2019; Shin et al., 2017). PEW is a malnourished problem and difficult to be assessed, while many studies demonstrated that PA is a practical indicator for this assessment (Player et al., 2019; Tan et al., 2019).…”

Low miR 511-5p Expression as a Potential Predictor of a Poor Nutritional Status in Head and Neck Cancer Patients Subjected to Intensity-Modulated Radiation Therapy

“…The high level of miR-181a expression along with a low value of the phase angle (PA) was associated with a higher risk of reducing FFM parameters (OR = 4.72; p = 0.04) and FFMI (OR = 3.21; p = 0.04). Moreover, patients with low PA and high expression of the studied miRNA had shorter OS (HR = 3.18; 95% Cl = 1.19-8.50; p = 0.002) [52].…”

Nutritional Deficiencies in Radiotherapy-Treated Head and Neck Cancer Patients

“…The presence of the A allele of the ITGAM significantly (over 14-fold) reduced the risk of severe disturbances in nutritional status assessed according to the SGA scale (OR = 0.07) during RT miRNA-130a [78] Patients with low miRNA expression had over a three-fold higher risk of BMI decrease below 18.5, over six-fold higher risk of losing over 5% of body weight, and higher risk of > 10% weight reduction OR = 14.18, after the RT miRNA-181a + PA [107] Patients with simultaneous presence of low PA and high miRNA expression were at a significantly higher risk of decreasing the FFMI < 14.9 kg/m 2 (OR = 5.14), FFM < 44.7 kg (OR = 6.20), and lean mass (OR = 10.0) during RT Elevations in inflammatory cytokines and impairments in leptin/ghrelin functioning are associated with symptoms of cancer cachexia. Moreover, leptin level can decrease after the commencement of RT [108].…”