Combined Amphotericin B-Flucytosine Therapy in Aspergillus Pneumonia

Codish, Stephen D.; Tobias, Jeffrey; Hannigan, Mary V.

doi:10.1001/jama.1979.03290480052025

Cited by 36 publications

(5 citation statements)

References 6 publications

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“…Amphotericin-B liposomal complex should be given to those patients who cannot tolerate high-dose amphotericin-B because of renal toxicity [62]. The combination of amphotericin-B and flucytosine is not only synergistic but allows the dosage of amphotericin to be reduced to less toxic levels [63]. Ketoconazole has a significant activity against Aspergillus spp.…”

Section: Diagnosis Of Invasive Aspergillosismentioning

confidence: 99%

Many faces of pulmonary aspergillosis

Sharma

Chwogule²

1998

Eur Respir J

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Aspergillus is a ubiquitous fungus. It is commonly isolated as an upper respiratory tract saprophyte and is the most frequent contaminant in laboratory specimens. Because species of aspergillus are omnipresent, one must be cautious in ascribing a causal role to the fungus obtained from patients. Aspergillus has low pathogenicity for humans and animals and rarely invades the immunologically competent host. Although the fungus can affect any organ system, the respiratory tract is involved in >90% of afflicted patients. Pulmonary aspergillosis, depending whether the host is atopic or immunosuppressed, may be classified under four categories: allergic or hypersensitivity syndromes, saprophytic colonization, invasive (infective) dissemination, and chemical or toxic pneumonitis. These entities differ clinically, radiologically, immunologically, and in their response to various therapeutic agents. An increased awareness, an aggressive approach to securing the diagnosis, and instituting early and appropriate therapy are needed to reduce the high morbidity and mortality caused by many of the aspergillus-related syndromes.

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Section: Diagnosis Of Invasive Aspergillosismentioning

confidence: 99%

Many faces of pulmonary aspergillosis

Sharma

Chwogule²

1998

Eur Respir J

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“…Moreover, anecdotal reports of cure of Aspergillus infections with combination therapy (3,4,9,11) have been difficult to interpret due to the variable influence of host factors.…”

mentioning

confidence: 99%

In vitro activities of amphotericin B in combination with four antifungal agents and rifampin against Aspergillus spp

Hughes¹,

Harris²,

Moody³

et al. 1984

Antimicrob Agents Chemother

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“…This is the reason it was added to our patient’s regimen [19, 20]. Considering poor clinical response to am B or other antifungals in some strains of Apsergillus , performing antifungal susceptibility testing in CGD patient is highly recommended.…”

Section: Discussionmentioning

confidence: 99%

Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient

et al. 2016

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Background and Purpose:Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infections in these patients. Case Report:Herein, we present a case of fungal infection in a girl with CGD. We confirmed aspergillosis through the positive microscopic and macroscopic examinations, as well as radiology results. Invasive aspergillosis in this patient with pneumonia, lung abscess, and osteomyelitis of the ribs was not initially treated with amphotericin B (Am B) and recombinant interferon-gamma.Conclusion:Among infectious diseases, fungal infections, in particular aspergillosis, remain a serious problem in CGD patients. Considering poor clinical response and deficient immune system, rapid diagnosis of fungal infection and optimizing the treatment of these patients are recommended.

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Combined Amphotericin B-Flucytosine Therapy in Aspergillus Pneumonia

Cited by 36 publications

References 6 publications

Many faces of pulmonary aspergillosis

Many faces of pulmonary aspergillosis

In vitro activities of amphotericin B in combination with four antifungal agents and rifampin against Aspergillus spp

Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient

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