Combined aerobic and resistance training improves physical capacity in women treated for gynecological cancer

Background The primary objective of this systematic review was to update our previous review on randomized controlled trials (RCTs) of exercise in cancers other than breast or prostate, evaluating: 1) the application of principles of exercise training within the exercise prescription; 2) reporting of the exercise prescription components (i.e., frequency, intensity, time, and type (FITT)); and 3) reporting of participant adherence to FITT. A secondary objective was to examine whether reporting of these interventions had improved over time. Methods MEDLINE, EMBASE, CINAHL and SPORTDiscus databases were searched from 2012 to 2020. Eligible studies were RCTs of at least 4 weeks of aerobic and/or resistance exercise that reported on physiological outcomes relating to exercise (e.g., aerobic capacity, muscular strength) in people with cancer other than breast or prostate. Results Eighty-six new studies were identified in the updated search, for a total of 107 studies included in this review. The principle of specificity was applied by 91%, progression by 32%, overload by 46%, initial values by 72%, reversibility by 7% and diminishing returns by 5%. A significant increase in the percentage of studies that appropriately reported initial values (46 to 80%, p < 0.001) and progression (15 to 37%, p = 0.039) was found for studies published after 2011 compared to older studies. All four FITT prescription components were fully reported in the methods in 58% of all studies, which was higher than the proportion that fully reported adherence to the FITT prescription components in the results (7% of studies). Reporting of the FITT exercise prescription components and FITT adherence did not improve in studies published after 2011 compared to older studies. Conclusion Full reporting of exercise prescription and adherence still needs improvement within exercise oncology RCTs. Some aspects of exercise intervention reporting have improved since 2011, including the reporting of the principles of progression and initial values. Enhancing the reporting of exercise prescriptions, particularly FITT adherence, may provide better context for interpreting study results and improve research to practice translation.

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“… + + + + + + + + None Gehring 2018 [ 72 ] + ? + + NR NR + + NR + + + + + None Hausmann 2018 [ 73 ] + NR NR NR ? ?…”

Section: Resultsmentioning

confidence: 99%

Attention to principles of exercise training: an updated systematic review of randomized controlled trials in cancers other than breast and prostate

et al. 2021

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“…7 Þetta er í samraemi við norska rannsókn sem sýndi að konur sem fengu ekki markvissa íhlutun í formi þjálfunar misstu þrek á ári á meðan konur sem höfðu fengið þjálfunaríhlutun í 16 vikur og íhlutun síðan haett voru enn með baett þrek ári seinna. 23 Regluleg hreyfing er mjög gagnleg fólki sem greinist með krabbamein, meðal annars vegna þess að hreyfing getur spornað gegn því að fólk þyngist. 12,13,24 Regluleg hreyfing getur einnig dregið úr líkum á því að fólk greinist með ýmsar tegundir krabbameina.…”

Section: Inngangurunclassified

Þrek, holdafar og heilsutengd lífsgæði eftir krabbameinsmeðferð

Guðmundsson

Jóhannsson

2020

LBL

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“…Gorzelitz et al, 2022 [ 30 ] USA 40 I 20 C 20 95% Endometrial (100%) 34.8±15.0 I (83%) II (5%) III (12%) Surgery (75%) Chemo (8%) Radio (7%) Chemo + Radio (10%) I 61±10 C 61±8 I 42.2±19.5 C 37.9±8.6 6. Hausmann et al, 2018 [ 31 ] Norway 60 I 21 C 16 90% Ovarian (25%) Cervical (27%) Uterine (47%) Vulva (1%) NR NR Surgery (93%) 1 Chemo (47%) 1 Radio (13%) 1 57±13 NR 7a. Iyer et al, 2018 [ 32 ] USA 95 I 50 C 45 I 84% C 82% Ovarian (100%) 18.8±10.8 I (27%) II (23%) III (32%) IV (18%) Surgery (76%) 1 Chemo (88%) 1 I 58±9 C 59±7 I 28.8±7.1 C 29.9±6.6 7b.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of exercise interventions for women during and after gynaecological cancer treatment – a systematic scoping review

Rose

Stewart

Clifford

et al. 2023

Support Care Cancer

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Purpose To systematically synthesise evidence of exercise intervention efficacy for physical/psychosocial outcomes that matter to women during/following treatment for gynaecological cancer. Methods Five databases were searched (PubMed, EMBASE, CINAHL, PsychInfo, Scopus). Exercise-only intervention studies that included women during/ following treatment for any gynaecological cancer, with/ without control comparison, on any physical or psychosocial outcome(s), were included and qualitatively appraised using the Revised Cochrane Risk of Bias tool and a modified Newcastle-Ottawa Scale. Results Seven randomised controlled trials (RCTs), three single-arm pre-post studies, and one prospective cohort study satisfied were included (11 studies). Most studies were completed following treatment (91%), included combined (aerobic and resistance; 36%) and aerobic (36%) training, were fully/mostly (63%) unsupervised, and had a moderate-to-high risk of bias. Overall, 33 outcomes (64% objectively-measured) were assessed. Improvements were observed in aerobic capacity (V̇O2 Peak +1.6 mL/kg/min, 6-minute walk distance +20-27 m), lower- (30-second sit-to-stand +2-4 repetitions) and upper-limb strength (30-second arm curl +5 repetitions; 1RM grip strength/chest press +2.4-3.1 kg), and agility (timed up-and-go -0.6 seconds). However, changes in quality of life, anthropometry/body composition, balance and flexibility were inconsistent. There was no evidence to support worsening of outcomes. Conclusion Preliminary research into the role of exercise post-gynaecological cancer suggests an improvement in exercise capacity, muscular strength, and agility which, in the absence of exercise, typically decline following gynaecological cancer. Future exercise trials involving larger and more diverse gynaecological cancer samples will improve understanding of the potential and magnitude of effect of guideline-recommended exercise on outcomes that matter to patients.

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Combined aerobic and resistance training improves physical capacity in women treated for gynecological cancer

Abstract: Combined aerobic and resistance training twice a week in 16 weeks improves V̇O and maximal strength in women treated for gynecological cancer. The training effects were sustained after 1 year in the PT group.

Cited by 7 publications

References 39 publications

Attention to principles of exercise training: an updated systematic review of randomized controlled trials in cancers other than breast and prostate

Attention to principles of exercise training: an updated systematic review of randomized controlled trials in cancers other than breast and prostate

Þrek, holdafar og heilsutengd lífsgæði eftir krabbameinsmeðferð

Efficacy of exercise interventions for women during and after gynaecological cancer treatment – a systematic scoping review

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