Combined adenocarcinoma-carcinoid tumor of transverse colon

Bhattacharjee, Prosanta Kumar; Halder, Shyamal Kumar

doi:10.4103/0973-1482.126483

Cited by 3 publications

(2 citation statements)

References 5 publications

(8 reference statements)

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“…To our knowledge, about 10 cases of composite NET and adenocarcinoma arising in the colorectal region have been reported [ 2 – 6 ]. In addition to these colorectal cases, composite tumors of the stomach, small intestine, anal canal and gallbladder have also been documented [ 4 , 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although adenocarcinomas showing neuroendocrine differentiation or those mixed with high-grade neuroendocrine carcinoma (NEC) are sometimes encountered, composite tumors comprising NET G1 and adenocarcinoma are exceedingly rare. To the best of our knowledge, only 10 cases of possible composite NET and adenocarcinoma arising in the colorectal region have been reported in the English literature [ 2 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Composite neuroendocrine tumor and adenocarcinoma of the rectum

et al. 2017

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BackgroundAlthough adenocarcinomas showing neuroendocrine differentiation or those mixed with high-grade neuroendocrine carcinoma (NEC) are sometimes encountered, composite tumors comprising neuroendocrine tumor (NET) Grade 1 and adenocarcinoma are exceedingly rare.Case presentationA 64-year-old male presented after testing positive for fecal occult blood at a medical check-up. A biopsy demonstrated the presence of a NET and endoscopic submucosal dissection was undertaken. Histologic examination revealed that a well differentiated tubular adenocarcinoma was present in addition to the NET. Furthermore, histological transition between the two tumors was evident. Accordingly, this case was considered to be a composite tumor comprising NET and adenocarcinoma.ConclusionComposite tumors consisting of NET Grade 1 and adenocarcinoma are exceedingly rare, and only a few examples have been reported hitherto.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Composite neuroendocrine tumor and adenocarcinoma of the rectum

et al. 2017

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Mechanistic and Therapeutic Advances in Colon Cancer: A Systematic Review

Li¹,

Han²,

Zhang³

et al. 2019

Open J Proteom Genom

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Colon cancer is a common gastrointestinal malignancy in daily life and is the third most common cancer. So far, the global incidence of colon cancer has risen every year. Colon cancer mortality accounts for half of the incidence, colon cancer mortality ranks fi fth in malignant tumor mortality, which seriously threatens human survival and health. This article refers to the latest domestic and foreign related articles related to colon cancer. It summarizes common and emerging screening methods for colon cancer which can make early detection and early treatment of the disease for reducing the deterioration and metastasis of colon cancer. It discusses the diagnostic markers of colon cancer found out in recent years and its mechanism of action, to improve the level, accuracy and scientifi city of diagnosis. This article points out that the metastasis of colon cancer is the main cause of death in patients with colon cancer and to discuss the mechanism of its metastasis. It also summarizes the therapy thereof and advantages and disadvantages of colon cancer from different aspects such as intestinal fl ora, targeted therapy, traditional Chinese medicine and western medicine. Finally, the article summaries some methods that can effectively prevent colon cancer, reduce the occurrence of colon cancer from the source and improve people's quality of life.

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Mixed epithelial endocrine neoplasms of the colon and rectum – An evolution over time: A systematic review

Kanthan¹,

Tharmaradinam²,

Asif³

et al. 2020

WJG

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BACKGROUND Mixed tumors of the colon and rectum, composed of a combination of epithelial and endocrine elements of benign and malignant potential are rare neoplasms. These can occur anywhere in the gastrointestinal tract and are often diagnosed incidentally. Though they have been a well-documented entity in the pancreas, where the exocrine-endocrine mixed tumors have been known for a while, recognition and accurate diagnosis of these tumors in the colon and rectum, to date, remains a challenge. This is further compounded by the different terminologies that have been attributed to these lesions over the years adding to increased confusion and misclassification. Therefore, dedicated literature reviews of these lesions in the colon and rectum are inconsistent and are predominantly limited to case reports and case series of limited case numbers. Though, most of these tumors are high grade and of advanced stage, intermediate and low grade lesions of these mixed tumors are also increasingly been reported. There are no established independent consensus based guidelines for the therapeutic patient management of these unique lesions. AIM To provide a comprehensive targeted literature review of these complex mixed tumors in the colon and rectum that chronicles the evolution over time with summarization of historical perspectives of terminology and to further our understanding regarding their pathogenesis including genomic landscape, clinicoradiological features, pathology, treatment, prognosis, the current status of the management of the primary lesions, their recurrences and metastases. METHODS A comprehensive review of the published English literature was conducted using the search engines PubMed, MEDLINE and GOOGLE scholar. The following search terms [“mixed tumors colon” OR mixed endocrine/neuroendocrine tumor/neoplasm/lesion colon OR adenocarcinoma and endocrine/neuroendocrine tumor colon OR mixed adenocarcinoma and endocrine/neuroendocrine carcinoma colon OR Amphicrine tumors OR Collision tumors] were used. Eligibility criteria were defined and all potential relevant items, including full articles and/or abstracts were independently reviewed, assessed and agreed upon items were selected for in-depth analysis. RESULTS In total 237 full articles/abstracts documents were considered for eligibility of which 45 articles were illegible resulting in a total of 192 articles that were assessed for eligibility of which 139 have been selected for reference in this current review. This seminal manuscript is a one stop article that provides a detailed outlook on the evolution over time with summarization of historical perspectives, nomenclature, clinicoradiological features, pathology, treatment, prognosis and the current status of the management of both the primary lesions, their recurrences and metastases. Gaps in knowledge have also been identified and discussed. An important outcome of this manuscript is the justified prop...

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Combined adenocarcinoma-carcinoid tumor of transverse colon

Cited by 3 publications

References 5 publications

Composite neuroendocrine tumor and adenocarcinoma of the rectum

Composite neuroendocrine tumor and adenocarcinoma of the rectum

Mechanistic and Therapeutic Advances in Colon Cancer: A Systematic Review

Mixed epithelial endocrine neoplasms of the colon and rectum – An evolution over time: A systematic review

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