Combined Actions of Quinidine and Digitalis on the Heart

Gold, Harry; Modell, Walter; Price, Leo

doi:10.1001/archinte.1932.00150180119008

Cited by 31 publications

(3 citation statements)

References 16 publications

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“…Gold et al [71] cautioned against use of quinidine and digi talis and years ago, and current data seem to bear out this observation.…”

Section: Antiarrhythmic Drugsmentioning

confidence: 80%

Clinical Use of Digitalis Glycosides

Doherty¹

1985

Cardiology

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Digitalis glycosides continue to place high on the list of prescribed drugs. Digoxin is 8th on prescriptions written in the United States in 1980, digitoxin 16th, and digitalis leaf 23rd. There is little doubt that most physicians continue to believe these drugs are useful. The application of more definite indications, smaller doses, and the recognition of the role of pharmacokinetics and drug interactions make use of the glycosides more challenging than ever before in 1985.

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“…Gold et al [71] cautioned against use of quinidine and digi talis and years ago, and current data seem to bear out this observation.…”

Section: Antiarrhythmic Drugsmentioning

confidence: 80%

Clinical Use of Digitalis Glycosides

Doherty¹

1985

Cardiology

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“…One of these was quinidine, a chemical extraction from quinine used in the treatment of cardiovascular diseases (or "disorders of the heart"). 64 By the late 1950s, the Dutch quinine industry (the Nedchem combination) and the German manufacturer Boehringer were the two largest quinidine producers in the world. 65 Furthermore, quinine became a much-in-demand ingredient for tonic production.…”

Section: Nationalization and Changing Production And Trade Network Imentioning

confidence: 99%

From Colonial Agro-Industrialism to Agro-Industrialism: game changing evolution of the Dutch transoceanic cinchona-quinine enterprise (1940s–1960s)

Hoogte¹,

Pieters²

2016

Itinerario

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By the turn of the twentieth century, the Dutch colony of the Netherlands Indies dominated the worldwide supply of antifebrifuge (to reduce fever) cinchona bark, the raw material for quinine, an antimalarial medicine. Over the next four decades, the high-quality and laboratory-conditioned cultivation of cinchona became the backbone of a Dutch transoceanic cinchona-quinine enterprise that dominated the international quinine markets. However, in the two decades after the Second World War, the Netherlands Indies’ cinchona bark dominance ended, and the Dutch transoceanic cinchona-quinine production and trade network collapsed. How can we explain this shift? In this study, we argue that this change was part of a process of globalization of cinchona bark production that created new sources and transoceanic production and distribution chains and hence new networks of control that were increasingly less associated with a specific nation than with multinational companies. Colonial networks of control were replaced by new industrial networks of control, and the colonial agro-industrial system was reconfigured into a global agro-industrial system. At the same time, this study also shows that the economic decolonization of Indonesia forced a process of deglobalization that resulted in a translocation of the cinchona-quinine trade networks. As such, this study shows a mix of globalization and deglobalization happening in tandem with Indonesian decolonization and agricultural globalization.

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“…The concomitant use of digoxin and quinidine is an accepted drug combination, but there are hazards in its use (Gold et al 1932). When quinidine is given to patients (Ejvinsson 1978;Doering 1979; Leahey et al 1978;Schenck-Gustafsson et a1 1981), dogs (Gibson & Nelson 1980) or guinea-pigs (Kim et al 1981;Geiger et al 1982;Sat0 et al 1983) receiving digoxin, the serum digoxin concentration increases.…”

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confidence: 99%

Effect of quinidine on the tissue binding of digoxin in guinea-pigs

Okudaira

Sawada

Sugiyama

et al. 1986

Journal of Pharmacy and Pharmacology

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The mechanism of quinidine-induced decrease in the tissue distribution of digoxin to heart, liver and skeletal muscle has been examined in guinea-pigs. Quinidine, in the presence of adenosine-5'-triphosphate (ATP), inhibited the specific binding of digoxin in homogenates of heart, liver and muscle, while in the absence of ATP the inhibition was observed only in heart. The decrease in the tissue-to-plasma unbound concentration ratios (Kpu) of heart and muscle determined from in-vitro binding studies was comparable to that in the Kpu values observed in-vivo, while in liver it was not sufficient to account for the fall in Kpuin-vivo values. It is concluded that quinidine-induced decrease in the tissue distribution of digoxin in heart and muscle is due to inhibition of tissue binding of this drug, while that in liver could be partially attributed to the decrease in the tissue binding.

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Combined Actions of Quinidine and Digitalis on the Heart

Cited by 31 publications

References 16 publications

Clinical Use of Digitalis Glycosides

Clinical Use of Digitalis Glycosides

From Colonial Agro-Industrialism to Agro-Industrialism: game changing evolution of the Dutch transoceanic cinchona-quinine enterprise (1940s–1960s)

Effect of quinidine on the tissue binding of digoxin in guinea-pigs

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