Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats

Lavich, Tatiana Ramos; Cordeiro, Renato S.B.; Calixto, João B.; Silva, Patrı́cia M.R. e; Martins, Marco A.

doi:10.1016/s0014-2999(02)02947-3

Cited by 21 publications

(23 citation statements)

References 34 publications

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“…This indicates that the carrageenan challenge was capable of triggering a hyperalgesic response, which was very rapid in onset, peaking within 15 to 60 min post-challenge and remaining significant for at least 6 h. Moreover, the ability to develop carrageenaninduced thermal hyperalgesia was completely absent in rats pretreated intraperitoneally with indomethacin. This agrees with the interpretation that the modified hot-plate test is suitable for the detection of peripheral hyperalgesia, as supported by our previous study using stimuli such as antigen, histamine, 5-hydroxytryptamine or bradykinin (14).…”

Section: Discussionsupporting

confidence: 92%

A novel hot-plate test sensitive to hyperalgesic stimuli and non-opioid analgesics

Lavich

Cordeiro

Silva

et al. 2005

Braz J Med Biol Res

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It is widely accepted that the classical constant-temperature hotplate test is insensitive to cyclooxygenase inhibitors. In the current study, we developed a variant of the hot-plate test procedure (modified hot-plate (MHP) test) to measure inflammatory nociception in freely moving rats and mice. Following left and right hind paw stimulation with a phlogogen and vehicle, respectively, the animals were placed individually on a hot-plate surface at 51ºC and the withdrawal latency for each paw was determined simultaneously in measurements performed at 15, 60, 180, and 360 min post-challenge. Plantar stimulation of rats (250 and 500 µg/paw) and mice (125-500 µg/paw) with carrageenan led to a rapid hyperalgesic response of the ipsilateral paw that reached a plateau from 15 to 360 min after challenge. Pretreatment with indomethacin (4 mg/kg, ip) inhibited the phenomenon at all the times analyzed. Similarly, plantar stimulation of rats and mice with prostaglandin E 2 (0.5 and 1 µg/ paw) also resulted in rapid hyperalgesia which was first detected 15 min post-challenge. Finally, we observed that the MHP test was more sensitive than the classical Hargreaves' test, being able to detect about 4-and 10-fold lower doses of prostaglandin E 2 and carrageenan, respectively. In conclusion, the MHP test is a simple and sensitive method for detecting peripheral hyperalgesia and analgesia in rats and mice. This test represents a low-cost alternative for the study of inflammatory pain in freely moving animals.

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Section: Discussionsupporting

confidence: 92%

A novel hot-plate test sensitive to hyperalgesic stimuli and non-opioid analgesics

Lavich

Cordeiro

Silva

et al. 2005

Braz J Med Biol Res

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“…However, further studies have to be carried out to fully elucidate the anti-allergic mechanisms of TNTP and C. guianensis seed oil. Allergic reactions are frequently accompanied by the onset of pain (or nociception) and hyperalgesia (i. e. sensitization to noxious stimuli) [20,32]. Indeed, Lavich and coworkers [20] showed that allergen-induced thermal hyperalgesia in rats is mediated by the synergistic effects of bradykinin, serotonin and histamine.…”

Section: Discussionmentioning

confidence: 99%

“…Bradykinin B 2 receptor antagonists, such as HOE 140, attenuate airway microvascular permeability and plasma leakage into the pleural cavity, trachea, bronchi and nasal mucosa of antigen-challenged rats and guinea-pigs [10,[15][16][17][18]. Bradykinin has also shown to be involved in hyperalgesia, since B 1 and B 2 receptor antagonists inhibited hyperalgesia in different experimental models of inflammation and allergy [19,20].…”

Section: Introductionmentioning

confidence: 99%

Anti-allergic effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on allergen-induced vascular permeability and hyperalgesia

et al. 2005

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Objective: We investigated the anti-allergic and analgesic properties of an oil and a derived fraction of tetranortriterpenoids (TNTP) obtained from the seeds of Carapa guianensis Aublet. Materials and methods: Pleurisy, paw and ear edema were induced in Swiss and C57/Bl10 mice mice, whereas thermal hyperalgesia was assessed in Wistar rats (n = 6 -10 per group). Values of p < 0.05 were regarded as significant. Results: C. guianensis oil (100 to 400 mg/kg, p. o.) and TNTP (12.5 to 100 mg/kg, p. o.) inhibited pleural exudation, paw and ear edema induced by ovalbumin (OVA) in sensitized mice. TNTP (12.5 to 100 mg/kg, p. o.) also inhibited paw edema induced by histamine, PAF and bradykinin. TNTP (100 mg/kg, p. o.) inhibited prostaglandin E 2 generation in the pleural cavity in response to antigenic challenge. Moreover, C. guianensis oil (100 to 400 mg/kg) and TNTP (12.5 to 100 mg/kg) decreased OVA-and histamine-induced hyperalgesia. Conclusion: Taken together, these findings demonstrate the anti-edematogenic and analgesic effects of C. guianensis oil, and points out TNTP as the responsible bioactive compounds.

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“…(BARNES et al, 1988). Além disso, elas estão implicadas em processos nociceptivos em diversas condições inflamatórias (BESSON, 1997), inclusive em humanos (SCIBERRAS et al, 1987), bem como na formação do edema (KAY, 2001), a histamina e a serotonina agem sinergicamente com a bradicinina induzindo hiperalgesia térmica (LAVICH et al, 2003).…”

Section: Corticosteróides Como a Dexametasona Indiretamente Inibem Founclassified

“…Esta amina está envolvida na nocicepção e inflamação através de receptores serotoninérgicos 5-HT 1 , 5-HT 2 , 5-HT 3 , 5-HT 4 and 5-HT 7 (SUFKA et al, 1992;DOAK & SAWYNOK, 1997;PARADA et al, 2001;LAVICH et al, 2003).…”

Section: Corticosteróides Como a Dexametasona Indiretamente Inibem Founclassified

Alterações locais induzidas pela secreção tóxicas de Philodryas patagoniensis (Girard, 1857) (Serpentes: Colubridae)

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Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats

Cited by 21 publications

References 34 publications

A novel hot-plate test sensitive to hyperalgesic stimuli and non-opioid analgesics

A novel hot-plate test sensitive to hyperalgesic stimuli and non-opioid analgesics

Anti-allergic effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on allergen-induced vascular permeability and hyperalgesia

Alterações locais induzidas pela secreção tóxicas de Philodryas patagoniensis (Girard, 1857) (Serpentes: Colubridae)

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