Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD

Borroni, Barbara; Anchisi, Davide; Paghera, Barbara; Vicini, B.; Kerrouche, Nacer; Garibotto, Valentina; Terzi, Arturo; Vignolo, Luigi A.; Luca, Monica Di; Giubbini, Raffaele; Padovani, Alessandro; Perani, Daniela

doi:10.1016/j.neurobiolaging.2004.12.010

Cited by 148 publications

(88 citation statements)

References 22 publications

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“…This is in accordance with the majority of previous studies, showing that functional abnormalities in the parietal cortex have the highest predictive values for the future development of AD compared to other brain regions [1,6,8,[18][19][20]25]. However, this is not an unequivocal finding as some other studies have suggested that decreased rCBF in the posterior cingulated gyrus is superior in detecting incipient AD among subjects with MCI [22,23,27].The reason for this discrepancy is unknown, although differences in instrumentation and variations in the affection of brain areas in this heterogeneous population of subjects with MCI may be possible explanations.…”

Section: Discussionsupporting

confidence: 93%

“…However, this is not an unequivocal finding as some other studies have suggested that decreased rCBF in the posterior cingulated gyrus is superior in detecting incipient AD among subjects with MCI [22,23,27].The reason for this discrepancy is unknown, although differences in instrumentation and variations in the affection of brain areas in this heterogeneous population of subjects with MCI may be possible explanations. From a methodological point of view, the predictive accuracy of cortical rCBF obtained with the present 133 Xe method was very similar to previously reported SPECT studies [6,[18][19][20]. In fact, the reported areas under the ROC curves for the power of SPECT to predict AD in MCI populations show a range between 74 to 82 % [7,12,[19][20][21], which is quite similar to the 78 % we found for parietal rCBF in the present study.…”

Section: Discussionsupporting

confidence: 91%

“…Several studies using single photon emission computed tomography (SPECT) have shown that decreased rCBF in temporo-parietal cortex and posterior cingulate cortex can identify incipient AD among subjects with MCI [6,[18][19][20]22].…”

Section: Introductionmentioning

confidence: 99%

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Combined rCBF and CSF biomarkers predict progression from mild cognitive impairment to Alzheimer's disease

Hansson

Buchhave

Zetterberg

et al. 2009

Neurobiology of Aging

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

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Combined rCBF and CSF biomarkers predict progression from mild cognitive impairment to Alzheimer's disease

Hansson

Buchhave

Zetterberg

et al. 2009

Neurobiology of Aging

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“…CCH can be detected in mild cognitive impairment prior to dementia using different imaging techniques (Borroni et al, 2006). CCH causes capillary degeneration, which reduces the diffusion of nutrition and oxygen supply to brain cells resulting in the degeneration of the nerve tissue.…”

Section: Introductionmentioning

confidence: 99%

Chronic Cerebral Hypoperfusion Induced Synaptic Proteome Changes in the rat Cerebral Cortex

et al. 2017

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Chronic cerebral hypoperfusion (CCH) evokes mild cognitive impairment (MCI) and contributes to the progression of vascular dementia and Alzheimer's disease (AD). How CCH 2 induces these neurodegenerative processes that may spread along the synaptic network and whether they are detectable at the synaptic proteome level of the cerebral cortex remains to be established.In the present study, we report the synaptic protein changes in the cerebral cortex after stepwise bilateral common carotid artery occlusion (BCCAO) induced CCH in the rat. The occlusions were confirmed with Magnetic Resonance Angiography 5 weeks after the surgery.Synaptosome fractions were prepared using sucrose gradient centrifugation from cerebral cortex dissected 7 weeks after the occlusion. The synaptic protein differences between the sham operated and CCH groups were analysed with label free nanoUHPLC-MS/MS.

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“…99mTc-ethyl cysteinate dimer SPECT imaging was used to detect regional hypoperfusion in the two Italian patients compared with 15 age-matched normal controls, using previously described procedures. 18 Image preprocessing (spatial normalization to a standard Montreal Neurological Institute SPECT template and 12-mm FWHM smoothing) and statistical analysis were implemented in SPM99 using standard validated procedures. 19 Age and total global distribution of the tracer's uptake were entered as confounding variables.…”

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confidence: 99%

The logopenic/phonological variant of primary progressive aphasia

et al. 2008

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Objective: Primary progressive aphasia (PPA) is characterized by isolated decline in language functions. Semantic dementia and progressive nonfluent aphasia are accepted PPA variants. A "logopenic" variant (LPA) has also been proposed, but its cognitive and anatomic profile is less defined. The aim of this study was to establish the cognitive and anatomic features of LPA.Methods: Six previously unreported LPA cases underwent extensive neuropsychological evaluation and an experimental study of phonological loop functions, including auditory and visual span tasks with digits, letters, and words. For each patient, a voxel-wise, automated analysis of MRI or SPECT data were conducted using SPM2. Results:In LPA, speech rate was slow, with long word-finding pauses. Grammar and articulation were preserved, although phonological paraphasias could be present. Repetition and comprehension were impaired for sentences but preserved for single words, and naming was moderately affected. Investigation of phonological loop functions showed that patients were severely impaired in digit, letter, and word span tasks. Performance did not improve with pointing, was influenced by word length, and did not show the normal phonological similarity effect. Atrophy or decreased blood flow was consistently found in the posterior portion of the left superior and middle temporal gyri and inferior parietal lobule.

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Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD

Cited by 148 publications

References 22 publications

Combined rCBF and CSF biomarkers predict progression from mild cognitive impairment to Alzheimer's disease

Combined rCBF and CSF biomarkers predict progression from mild cognitive impairment to Alzheimer's disease

Chronic Cerebral Hypoperfusion Induced Synaptic Proteome Changes in the rat Cerebral Cortex

The logopenic/phonological variant of primary progressive aphasia

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