Combinatorial synthesis of fluorescent trialkylphosphine sulfides as sensor materials for metal ions of environmental concern

Abstract

A combinatorial library of diverse alkyl-phosphine sulfides bound to Merrifield, Argopore, Argogel and Wang resins was synthesized and evaluated for their sensing properties. The library consists of 12 products with the anthranyl group as a fluorophore and phosphine sulfide alkyl derivatives as receptors of transition and heavy metal ions. The fluorescence spectral characteristics and the properties as sensing phase of these materials towards Pb(II) and Cu(II) were established.

Design of fluorescent materials for chemical sensing

“…276 Castillo and Rivero has reported the use of alkylphosphine sulfides bound resins for Pb 2+ and Cu 2+ sensing. 283 Combinatorial chemistry has also been used to improve selectivity in some molecular imprinted polymers. 102 Parallel peptide synthesis was used for a cyclopeptide library attached to a glass surface that works as an amino acid sensor by reflectometric interference spectroscopy.…”

Combinatorial and High-Throughput Development of Sensing Materials: The First 10 Years

“…Additional practical challenges may occur from difficulties in the synthesis of those best reagent structures predicted from computations. Thus, combinatorial synthetic approaches have been applied for the development of new fluorescent − and colorimetric − reagents. Recent reviews are available on the fluorescent labels and probes. , Recent developments resulted in the discovery of a wide variety of new useful reagents for the detection of metal ions, ,,, ATP, GTP, dipeptides, tripeptides, and reagents that selectively bind to amyloid 332 and different cell components. , …”

“…Additional practical challenges may occur from difficulties in the synthesis of those best reagent structures predicted from computations. Thus, combinatorial synthetic approaches have been applied for the development of new fluorescent [329][330][331][332][333][334][335] and colorimetric [336][337][338][339] reagents. Recent reviews are available on the fluorescent labels and probes.…”

Combinatorial Strategies in Fluorescent Probe Development

“…The authors screened the library against aqueous copper solutions and prepared highly sensitive fluorescent dansyl sensors based on a newly discovered molecular entity. Rivero and co-workers similarly obtained fluorescence quenching probes for Cu 2+ and Pb 2+ from a small library of phosphine sulfides modified with anthracene fluorophores. , …”