Combinatorial Methods, Automated Synthesis and High‐Throughput Screening in Polymer Research: Past and Present

Hoogenboom, Richard; Meier, Mar Michael; Schubert, Ulrich S.

doi:10.1002/marc.200390013

Cited by 199 publications

(165 citation statements)

References 116 publications

(117 reference statements)

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“…To manage the rapid synthesis and screening, high-throughput approaches seem to be ideally suited. [7][8][9] High-throughput experimentation methods have also been applied by other research groups to determine structure-property relationships in, e.g., polymeric sensor materials, [10] crosslinked materials, [11] and biomaterials. [12] In our studies, we have chosen the cationic ring-opening polymerization of 2-oxazolines, which was first reported in 1966 by four independent research groups, [13][14][15][16] for the library preparation.…”

Section: Talents and Trendsmentioning

confidence: 99%

Poly(2‐oxazoline)s: Alive and Kicking

Hoogenboom

2007

Macro Chemistry & Physics

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109

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The development of various living/controlled polymerization techniques has allowed the synthesis of a large variety of well‐defined (co)polymers with varied polymer length, composition, and architecture, for example. Screening this large possible parameter space for a polymer with certain properties can be a very demanding process. Therefore, we aim to rapidly synthesize and systematically screen libraries of copolymers to determine structure‐property relationships that might allow the future design of novel (co)polymers with predictable properties. The cationic ring‐opening polymerization of 2‐oxazolines has been adapted for the synthesis of libraries of well‐defined (co)polymers. In this contribution, the optimization of the polymerization procedure using both high‐throughput experimentation and microwave irradiation is discussed. Subsequently, the microwave‐assisted synthesis of well‐defined libraries of (co)poly(2‐oxazoline)s and the determination of structure‐property relationships for these polymers is described. Moreover, the polymerization of a soy‐based 2‐oxazoline monomer will be illustrated as a ‘green’ approach to replace current oil‐based feedstock by renewable resources.magnified image

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Section: Talents and Trendsmentioning

confidence: 99%

Poly(2‐oxazoline)s: Alive and Kicking

Hoogenboom

2007

Macro Chemistry & Physics

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109

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“…[9] Genetic algorithms have already been used in the pharmaceutical industry, [10] material development [11] and catalysis [10] leading to successful implementation. These tools have also proven to be extremely useful in membrane technology to develop better performing membranes, directing membrane composition towards improved separation properties.…”

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confidence: 99%

Optimization of cellulose acetate nanofiltration membranes for micropollutant removal via genetic algorithms and high throughput experimentation

Cano-Òdena

Spilliers

Dedroog

et al. 2011

Journal of Membrane Science

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Nanofiltration (NF) and reverse osmosis (RO) membranes have a high potential to remove low molecular weight trace contaminants in water that cannot be removed efficiently by conventional biological or physico-chemical treatments. However, membrane performance depends on several parameters involved in membrane synthesis. Multi-parameter optimization strategies, such as genetic algorithms (GAs) are extremely promising to minimize time and material consumption to direct membrane synthesis towards better separation properties (selectivity) of the targeted compounds combined with useful fluxes.Cellulose acetate membranes were prepared via phase inversion. The optimized parameters included compositional (polymer concentration, solvent) and also, for first time when using GA as optimization strategy in membrane synthesis, non-compositional on the level of the 2 membrane synthesis process and post treatment (temperature, annealing time), which have a great impact on membrane performance.Dead-end filtrations were carried out to evaluate membrane performance to retain ibuprofen in water by using High-Throughput experimentation (HT), which enables parallel testing and rapid acquisition of data sets and minimize time and material consumption. Ibuprofen was selected as it is one of the smallest molecules from relevant micropollutants present in drinking water. As result, membranes with ibuprofen retention up to 96% and permeabilities in the normal range of cellulose acetate (CA)-based reverse osmosis membranes were obtained, which also showed promising NaCl retention and twice the permeability compared to membranes prepared via a classical optimization parameter-by-parameter.

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“…In case of polysaccharides, co-electrodeposition is applied after materials are dissolved or suspended in aqueous solution and integrated into thin films [142]. To produce thin film compositional libraries, premixing of biopolymer solutions followed by temperature gradient over the coating [55], casting processes [143], or flow-coating methods [144] have been used.…”

Section: Compositional Libraries Thin Films By C-maplementioning

confidence: 99%

Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

Axente¹,

Sima²,

Ristoscu³

et al. 2016

Recent Advances in Biopolymers

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This chapter provides an overview of recent advances in the field of laser-based synthesis of biopolymer thin films for biomedical applications. The introduction addresses the importance of biopolymer thin films with respect to several applications like tissue engineering, cell instructive environments, and drug delivery systems. The next section is devoted to applications of the fabrication of organic and hybrid organic-inorganic coatings. Matrix-assisted pulsed laser evaporation (MAPLE) and Combinatorial-MAPLE are introduced and compared with other conventional methods of thin films assembling on solid substrates. Advantages and limitations of the methods are pointed out by focusing on the delicate transfer of bio-macromolecules, preservation of properties and on the prospect of combinatorial libraries' synthesis in a single-step process. The following section provides a brief description of fundamental processes involved in the molecular transfer of delicate materials by MAPLE. Then, the chapter focuses on the laser synthesis of two polysaccharide thin films, namely Dextran doped with iron oxide nanoparticles and Levan, followed by an overview on the MAPLE synthesis of other biopolymers. The chapter ends with summary and perspectives of this fast-expanding research field, and a rich bibliographic database.

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Combinatorial Methods, Automated Synthesis and High‐Throughput Screening in Polymer Research: Past and Present

Cited by 199 publications

References 116 publications

Poly(2‐oxazoline)s: Alive and Kicking

Poly(2‐oxazoline)s: Alive and Kicking

Optimization of cellulose acetate nanofiltration membranes for micropollutant removal via genetic algorithms and high throughput experimentation

Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

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