Combinatorial/Library Peptide Synthesis

Lebl, Michal

doi:10.1002/9783527631827.ch12

Cited by 1 publication

(1 citation statement)

References 291 publications

(251 reference statements)

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“…Combinatorial techniques have allowed researchers to greatly expand the existing library of potential drug molecules since the mid 1980s. − While there are millions of potential drug molecules synthesized and available, it is vital to note how few actually are approved for human use. In many cases the overall toxicity of the drug molecule, insolubility and instability in biological systems, and undesired interactions (side effects) of the pharmaceutical can lead to the termination of promising clinical trials .…”

Section: Introductionmentioning

confidence: 99%

Chemically Reducible Lipid Bilayer Coated Mesoporous Silica Nanoparticles Demonstrating Controlled Release and HeLa and Normal Mouse Liver Cell Biocompatibility and Cellular Internalization

2012

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A controlled release system composed of mesoporous silica nanoparticles with covalently bound dipalmitoyl moieties supporting phosphorylated lipids has been successfully synthesized and characterized. This MSN system demonstrates controlled release of fluorescein molecules under disulfide reducing conditions. Flow cytometry analyses confirm increased biocompatibility of the resulting lipid bilayer MSNs (LB-MSNs) from nonfunctional MSNs. Fluorescently labeled LB-MSNs are examined via confocal fluorescent microscopy ex vivo and were found to enter both normal and cancer cell lines. The LB-MSNs presented here have potential to be used as rapid and diverse functionalized, stable liposome analogues for drug delivery.

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