Combinatorial chemotherapy via poloxamer 188 surface-modified PLGA nanoparticles that traverse the blood-brain-barrier in a glioblastoma model
Fatemeh Madani,
Hassan Morovvati,
Thomas J. Webster
et al.
Abstract:The effect of anti-glioblastoma therapies is dwindling due to insufficient delivery across the blood-brain-barrier. It has been stated that poloxamer 188-coated nanoparticles are able to circumvent the blood-brain-barrier. Building off of such success, this study presents the design, preparation, and evaluation of a combination of PLGA nanoparticles loaded with methotrexate (P-MTX NPs) and PLGA nanoparticles loaded with paclitaxel (P-PTX NPs) that were surface-modified by poloxamer188. Cranial tumors were impl… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.