Combinatorial chemistry methods for coating development

Chisholm, Bret J.; Potyrailo, Radislav A.; Shaffer, Ron; Cawse, James N.; Brennan, Michael J.; Molaison, Chris

doi:10.1016/j.porgcoat.2003.01.001

Cited by 7 publications

(3 citation statements)

References 1 publication

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“…[66,134,137,138] Coating libraries were prepared on plastic substrates by depositing the UV-curable formulation into wells created in a removable silicone template. [64] Several screening methods were developed to test the coatings for their key performance properties, which included adhesion to the substrate, [139] abrasion resistance, [140,141] and weathering.…”

Section: Applications Of Combinatorial and High-throughput Experimentmentioning

confidence: 99%

Combinatorial and High‐Throughput Methods in Macromolecular Materials Research and Development

Webster

2008

Macro Chemistry & Physics

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Combinatorial and high‐throughput experimentation is used to accelerate the rate of experimentation in macromolecular science. Combinatorial and high‐throughput methods are used in macromolecular science to discover and optimize catalysts for polymerization reactions, discover compositions that have specific desired properties, and systematically explore polymer structure–property relationships. The use of high‐throughput methods can enable the discovery of complex catalyst systems or polymer compositions that would not be feasible using conventional experimental methods. In addition, combinatorial data can be used as inputs into computer models to enable the accurate prediction of material properties as a function of composition.magnified image

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Section: Applications Of Combinatorial and High-throughput Experimentmentioning

confidence: 99%

Combinatorial and High‐Throughput Methods in Macromolecular Materials Research and Development

Webster

2008

Macro Chemistry & Physics

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“…Revisiting correlations between conventional and CHT testing must be done with each workflow to ensure satisfactory outcomes. CHT tests are generally designed to provide continuous quantitative responses in contrast to conventional coatings tests which are often observational, ordinal rankings with varying degrees of subjectivity. , …”

Section: Introductionmentioning

confidence: 99%

High-Throughput Industrial Coatings Research at The Dow Chemical Company

et al. 2016

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At The Dow Chemical Company, high-throughput research is an active area for developing new industrial coatings products. Using the principles of automation (i.e., using robotic instruments), parallel processing (i.e., prepare, process, and evaluate samples in parallel), and miniaturization (i.e., reduce sample size), high-throughput tools for synthesizing, formulating, and applying coating compositions have been developed at Dow. In addition, high-throughput workflows for measuring various coating properties, such as cure speed, hardness development, scratch resistance, impact toughness, resin compatibility, pot-life, surface defects, among others have also been developed in-house. These workflows correlate well with the traditional coatings tests, but they do not necessarily mimic those tests. The use of such high-throughput workflows in combination with smart experimental designs allows accelerated discovery and commercialization.

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“…In recent years, the combinatorial methodology originally developed within the pharmaceutical industry has been successfully applied to coating research and development as a means to reduce the time and cost for new coating development. – High-throughput (HT) methods for preparating, depositing, curing, and testing many key properties of surface coatings have been previously described. For example, a combinatorial workflow for the development of protective coatings for plastic substrates has been described in detail by Chisholm et al, while a complete combinatorial workflow for the development of new marine coatings has been described by Webster et al A key component of a combinatorial workflow for the development of new organic coatings for corrosion control is the generation of a HT method for assessment of corrosion protection.…”

Section: Introductionmentioning

confidence: 99%

Combinatorial Materials Research Applied to the Development of New Surface Coatings X: A High-Throughput Electrochemical Impedance Spectroscopy Method for Screening Organic Coatings for Corrosion Inhibition

Bahr

Chisholm

et al. 2008

J. Comb. Chem.

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The objective of the study was to develop a high-throughput electrochemical impedance spectroscopy (HT-EIS) method for rapid and quantitative evaluation of corrosion protective coatings. A 12-element, spatially addressable electrochemical platform was designed, fabricated, and validated. This platform was interfaced to a commercial EIS instrument through an automated electronic switching unit. The HT-EIS system enables four parallel EIS measurements to be run simultaneously, which significantly reduces characterization time compared to that of serial EIS measurements using a multiplexer. The performance of the HT-EIS system was validated using a series of model systems, including a Randles equivalent circuit, an electrochemical reaction (Ti/K4FeCN6, K3FeCN6), a highly uniform polymer film, and several polymer coatings. The results of the validation studies showed that the HT-EIS system enables a major reduction in characterization time and provides high quality data comparable to data obtained with conventional, single-cell EIS measurement systems.

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Combinatorial chemistry methods for coating development

Cited by 7 publications

References 1 publication

Combinatorial and High‐Throughput Methods in Macromolecular Materials Research and Development

Combinatorial and High‐Throughput Methods in Macromolecular Materials Research and Development

High-Throughput Industrial Coatings Research at The Dow Chemical Company

Combinatorial Materials Research Applied to the Development of New Surface Coatings X: A High-Throughput Electrochemical Impedance Spectroscopy Method for Screening Organic Coatings for Corrosion Inhibition

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