Combinatorial chemistry methods for coating development

Chisholm, Bret J.; Potyrailo, Radislav A.; Shaffer, Ron; Cawse, James N.; Brennan, Michael J.; Molaison, Chris

doi:10.1016/s0300-9440(03)00073-0

Cited by 22 publications

(8 citation statements)

References 5 publications

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“…4 subsequently measuring bacterial growth via turbidity measurements at 600 nm. The robot is equipped with a vibration table which facilitates spreading of the coating solutions across the surface of the aluminum substrates.…”

Section: Resultsmentioning

confidence: 99%

High Throughput Screening of Marine Coatings using Biological Assays

Stafslien¹,

Chisholm²,

Christianson³

et al. 2005

MRS Proc.

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A combinatorial workflow for developing organic surface coatings has been developed. The workflow is uniquely designed to prepare and evaluate marine coatings that prevent biofouling on the hulls of ships. A critical component of the workflow is the high throughput screening of settlement and ease of removal of marine organisms from coating surfaces. Methods have been developed to directly and indirectly quantify marine bacterial biofilm growth and retention. Correlations have been developed between these high throughput bioassays and results from ocean testing.

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Section: Resultsmentioning

confidence: 99%

High Throughput Screening of Marine Coatings using Biological Assays

Stafslien¹,

Chisholm²,

Christianson³

et al. 2005

MRS Proc.

Self Cite

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“…These basic concepts of high-throughput systems have also been applied in other fields, as for example materials research. Examples include the development of thermoelectric materials [51] and the development of abrasion resistive surfaces [52]. In these cases, the objects under test are functional materials, which can be tested by their surface characteristics.…”

Section: Acceleration Of High-throughput Systemsmentioning

confidence: 99%

Accelerating High-Throughput Screening for Structural Materials with Production Management Methods

2018

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High-throughput screenings are widely accepted for pharmaceutical developments for new substances and the development of new drugs with required characteristics by evolutionary studies. Current research projects transfer this principle of high-throughput testing to the development of metallic materials. In addition to new generating and testing methods, these types of high-throughput systems need a logistical control and handling method to reduce throughput time to get test results faster. Instead of the direct material flow found in classical high-throughput screenings, these systems have a very complex structure of material flow. The result is a highly dynamic system that includes short-term changes such as rerun stations, partial tests, and temporarily paced sequences between working systems. This paper presents a framework that divides the actions for system acceleration into three main sections. First, methods for special applications in high-throughput systems are designed or adapted to speed up the generation, treatment, and testing processes. Second, methods are needed to process trial plans and to control test orders, which can efficiently reduce waiting times. The third part of the framework describes procedures for handling samples. This reduces non-productive times and reduces order processing in individual lots.

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“…[66,134,137,138] Coating libraries were prepared on plastic substrates by depositing the UV-curable formulation into wells created in a removable silicone template. [64] Several screening methods were developed to test the coatings for their key performance properties, which included adhesion to the substrate, [139] abrasion resistance, [140,141] and weathering. [142] Researchers at North Dakota State University have developed a comprehensive system for high-throughput coatings development with an initial focus on coatings for underwater marine applications.…”

Section: Applications Of Combinatorial and High-throughput Experimentmentioning

confidence: 99%

Combinatorial and High‐Throughput Methods in Macromolecular Materials Research and Development

Webster

2008

Macro Chemistry & Physics

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Combinatorial and high‐throughput experimentation is used to accelerate the rate of experimentation in macromolecular science. Combinatorial and high‐throughput methods are used in macromolecular science to discover and optimize catalysts for polymerization reactions, discover compositions that have specific desired properties, and systematically explore polymer structure–property relationships. The use of high‐throughput methods can enable the discovery of complex catalyst systems or polymer compositions that would not be feasible using conventional experimental methods. In addition, combinatorial data can be used as inputs into computer models to enable the accurate prediction of material properties as a function of composition.magnified image

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Combinatorial chemistry methods for coating development

Cited by 22 publications

References 5 publications

High Throughput Screening of Marine Coatings using Biological Assays

High Throughput Screening of Marine Coatings using Biological Assays

Accelerating High-Throughput Screening for Structural Materials with Production Management Methods

Combinatorial and High‐Throughput Methods in Macromolecular Materials Research and Development

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