Combinatorial biosynthesis of plant-specific coumarins in bacteria

Lin, Yuheng; Sun, Xinxiao; Yuan, Qipeng; Yan, Yajun

doi:10.1016/j.ymben.2013.04.004

Cited by 83 publications

(76 citation statements)

References 56 publications

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“…The numbering of coumarin starts from the ring oxygen, i.e., oxygen receives position-1 and goes round anti-clockwise along with the ring (Keri et al 2015). Coumarins can be classified into four categories: simple coumarin, furanocoumarin, pyranocoumarin, and coumarin with substituent on the pyrone ring (Jain and Joshi 2012;Lin et al 2013b;Venugopala et al 2013;Rohini and Srikumar 2014), as shown in Table 1.…”

Section: Coumarins: Classifications and Propertiesmentioning

confidence: 99%

“…Coumarins and their derivatives have demonstrated a vast array of therapeutic applications including antioxidant, antibacterial, antiviral, anti-inflammatory, antinociceptive, antidepressant, antitumor, antiasthmatic, hepatoprotective, antiallergic, antifungal, and inhibiting serine protease and HIV (Aslam et al 2010;Kumar et al 2013;Lin et al 2013b;Patil et al 2013;Abdel-Wahab et al 2014;Vekariya and Patel 2014). They can be used as cholinesterase (ChE) inhibitors for the treatment of Alzheimer's disease and treating Parkinson's disease (Anand et al 2012;Sandhu et al 2014).…”

Section: Coumarins: Classifications and Propertiesmentioning

confidence: 99%

“…Although present in natural form, the isolation and purification of coumarins may be difficult, expensive, and oscillatory. There is the possibility that climatic factors can interfere in the accumulation of active principles of the plant (Lin et al 2013b;Venugopala et al 2013;Hara et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Fungi as a source of natural coumarins production

Costa

Tavares

Oliveira

2016

Appl Microbiol Biotechnol

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Natural coumarins and derivatives are compounds that occur naturally in several organisms (plant, bacteria, and fungi) consisting of fused benzene and α-pyrone rings. These compounds show high technological potential applications in agrochemical, food, pharmaceuticals, and cosmetics industries. Therefore, the need for bulk production of coumarins and the advancement of the chemical and pharmaceutical industries led to the development of synthetic coumarin. However, biotransformation process, synthetic bioengineering, metabolic engineering, and bioinformatics have proven effective in the production of natural products. Today, these biological systems are recognized as green chemistry innovation and business strategy. This review article aims to report the potential of fungi for synthesis of coumarin. These microorganisms are described as a source of natural products capable of synthesizing many bioactive metabolites. The features, classification, properties, and industrial applications of natural coumarins as well as new molecules obtained by basidiomycetes and ascomycetes fungi are reported in order to explore a topic not yet discussed in the scientific literature.

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Section: Coumarins: Classifications and Propertiesmentioning

confidence: 99%

Section: Coumarins: Classifications and Propertiesmentioning

confidence: 99%

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Fungi as a source of natural coumarins production

Costa

Tavares

Oliveira

2016

Appl Microbiol Biotechnol

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“…When using a tyrosine-overproducing strain, 767 mg/liter caffeic acid was produced in 72 h using shake flasks. In this work, the authors used Rhodotorula glutinis TAL (RgTAL), which was reported to be the most active TAL among all the identified ones (150,(173)(174)(175) (Table 4). Zhang and Stephanopoulos (152) also used RgTAL for caffeic acid biosynthesis, in an experiment using two parallel routes and a tyrosine overproducer strain (Fig.…”

Section: Figmentioning

confidence: 99%

Heterologous Production of Curcuminoids

Rodrigues

Prather

Kluskens

et al. 2015

Microbiol Mol Biol Rev

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SUMMARY Curcuminoids, components of the rhizome of turmeric, show several beneficial biological activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities. Despite their numerous pharmaceutically important properties, the low natural abundance of curcuminoids represents a major drawback for their use as therapeutic agents. Therefore, they represent attractive targets for heterologous production and metabolic engineering. The understanding of biosynthesis of curcuminoids in turmeric made remarkable advances in the last decade, and as a result, several efforts to produce them in heterologous organisms have been reported. The artificial biosynthetic pathway (e.g., in Escherichia coli ) can start with the supplementation of the amino acid tyrosine or phenylalanine or of carboxylic acids and lead to the production of several natural curcuminoids. Unnatural carboxylic acids can also be supplemented as precursors and lead to the production of unnatural compounds with possibly novel therapeutic properties. In this paper, we review the natural conversion of curcuminoids in turmeric and their production by E. coli using an artificial biosynthetic pathway. We also explore the potential of other enzymes discovered recently or already used in other similar biosynthetic pathways, such as flavonoids and stilbenoids, to increase curcuminoid yield and activity.

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“…Recent findings that coumarin is formed by the action of two hydroxylases allowed reconstruction of its biosynthetic pathway in microbial cells. Lin et al designed artificial biosynthetic pathways in E. coli [76] and produced scopoletin and umbelliferone from the corresponding De: tyrR phenylpropanoid acids, ferulic acid, caffeic acid, and 4-coumaric acid. They used TAL to produce scopoletin and umbelliferone from aromatic amino acids.…”

Section: Alkaloidsmentioning

confidence: 99%