Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs
Felix E. Y. Aggor,
Martinna Bertolini,
Bianca M. Coleman
et al.
Abstract:Oropharyngeal candidiasis (OPC) is the most common human fungal infection, arising typically from T cell immune impairments. IL-17 and IL-22 contribute individually to OPC responses, but here we demonstrate that the combined actions of both cytokines are essential for resistance to OPC. Mice lacking IL-17RA and IL-22RA1 exhibited high fungal loads in esophagus- and intestinal tract, severe weight loss, and symptoms of colitis. Ultimately, mice succumbed to infection. Dual loss of IL-17RA and IL-22RA impaired e… Show more
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