Combinations of Interleukin-10 Gene Promoter Polymorphisms with -1082A, -819T, -592A Minor Allele are Associated with Sinonasal Polyposis

Abstract

Sinonasal polyposis (SP) is a cronic inflammation of the sinonasal mucosa. Chronic sinusitis, odor loss headache and nasal obstruction are among the clinical symptoms of SP with low life quality among the patients. Sinonasal polyposis is often accompanied by allergic rhinitis, allergy, aspirin susceptibility and asthma [1]. SP has been implicated in many immunological pathways and is a localized manifestation of systemic disorders [2,3]. SP cases frequently accompanied by T helper (Th) type 1-, Th2-, or Th17-biased inflammatory processes regulated by increased expression levels of a number of cytokines with pro-and anti-inflammatory activities [4]. However, the underlying etiology of SP is multifactorial. Also the pathogenesis of SP is still unexplained.Interleukin (IL)-10 is a crucial Th2 group anti-inf-