Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk

Su, Kuo Jung; Ho, Chuan Chen; Lin, Chiao‐Wen; Chen, Mu Kuan; Su, Shih Chi; Yu, Yung Luen; Yang, Shun Fa

doi:10.1007/s13277-015-4367-1

Cited by 11 publications

(9 citation statements)

References 18 publications

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“…For example, increased expression of FUT1 has been associated with increased propensity to metastasize in melanoma and advanced stage in ovarian cancer, while downregulation of FUT1 in a HER2-positive breast cancer cell line decreased proliferation [92–94]. DNA variants in FUT2 has been associated with increased risk of oral cancer in individuals who smoke and/or chew betel quid while in pancreatic cancer, secretor status was not associated with risk [95,96]. In an evaluation of variants within FUT loci variants within FUT2 and FUT3 were associated with interstinal- and diffuse-type gastric cancer, respectively [97].…”

Section: Modification Of Abo Phenotypesmentioning

confidence: 99%

The role of the histoblood ABO group in cancer

Rummel

Ellsworth²

2016

Future Sci. OA

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Since the first link between blood type and cancer was described in 1953, numerous studies have sought to determine whether the histoblood ABO group is associated with tumorigenesis. In 2009, the first significant association between a SNP located within the ABO glycosyltransferase gene and increased risk of pancreatic cancer was reported. Here, we describe the history and possible functions of the histoblood ABO group and then provide evidence for a role of blood group antigens in the most common cancer types worldwide using both blood type and SNP data. We also explore whether confusion regarding the role of blood type in cancer risk may be attributable to heterogeneity within tumor types.

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Section: Modification Of Abo Phenotypesmentioning

confidence: 99%

The role of the histoblood ABO group in cancer

Rummel

Ellsworth²

2016

Future Sci. OA

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“…The association of rs1047781 with cancer antigen 19-9 (CA19-9) levels and carcinoembryonic antigen (CEA) concentration in esophageal squamous cell cancer and pancreatic cancer also was confirmed by genome-wide association studies 16 . Moreover, our previously study also shown that interactions of FUT2 polymorphisms with betel quid chewing habits maybe altering oral cancer susceptibility 17 . However, the effects of FUT2 polymorphisms are still unclear in HCC.…”

Section: Introductionmentioning

confidence: 81%

“…Allelic discrimination of the FUT2 polymorphisms rs281377, rs1047781, rs601338, and rs602662 was assessed using an ABI StepOne Real-Time PCR System (Applied Biosystems), SDS v3.0 software (Applied Biosystems), and the TaqMan assay 17 - 19 . The final volume for each reaction was 5 μL, containing 2.5 μL TaqMan Genotyping Master Mix, 0.125 μL TaqMan probes mix, and 10 ng genomic DNA.…”

Section: Methodsmentioning

confidence: 99%

FUT2 genetic variants as predictors of tumor development with hepatocellular carcinoma

et al. 2017

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Lewis antigens related to the ABO blood group are fucosylated oligosaccharides and are synthesized by specific glycosyltransferases (FUTs). FUTs are involved in various biological processes including cell adhesion and tumor progression. The fucosyltransferase-2 gene (FUT2) encodes alpha (1,2) fucosyltransferase, which is responsible for the addition of the alpha (1,2)-linkage of fucose to glycans. Aberrant fucosylation occurs frequently during the development and progression of hepatocellular carcinoma (HCC). However, the association of FUT2 polymorphisms with HCC development has not been studied. Therefore, we aimed to investigate the association of FUT2 polymorphisms with demographic, etiological, and clinical characteristics and with susceptibility to HCC. In this study, a total of 339 patients and 720 controls were recruited. The genotypes of FUT2 at four single-nucleotide polymorphisms (SNPs; rs281377, rs1047781, rs601338, and rs602662) were detected by real-time polymerase chain reaction from these samples. Compared with the wild-type genotype at SNP rs1047781, which is homozygous for nucleotides AA, at least one polymorphic T allele (AT or TT) displayed significant association with clinical stage (p = 0.048) and tumor size (p = 0.022). Our study strongly implicates the polymorphic locus rs1047781 of FUT2 as being associated with HCC development.

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“…Genes such as ALDOB (aldolase, fructose-bisphosphate B) [68], KHK (ketohexokinase) [69], CHRNA7 [70], GSTA3 [71], APOA1 [72], CEBPA (CCAAT enhancer binding protein alpha) [73], PCK1 [74], ATP1A1 [75], CLCA1 [76], EMB (embigin) [77], SLC22A18 [78], FUT5 [79] and ITLN1 [80] were linked with progression of various cancer types, but these genes might be identified with growth of NET. Polymorphic genes such as GSTA1 [81], GSTA2 [82], MGST1 [83], NAT2 [84], SULT1A2 [85], SULT2A1 [86], UGT1A6 [87], UGT2B15 [88], UGT2B17 [89], ABCC2 [90], FUT2 [91] and APOB (apolipoprotein B) [92] were liable for progression of various cancer types, but these polymorphic genes might be diagnosed with growth of NET. Genes such as G6PC [93] and SGK1 [94] were associated with proliferation of various cancer cells types, but these gene might be linked with proliferation of NET cells.…”

Section: Discussionmentioning

confidence: 99%

Identification of key genes and associated pathways in neuroendocrine tumors through bioinformatics analysis and predictions of small drug molecules

Devarbhavi

Vastrad²,

Tengli

et al. 2020

Preprint

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Neuroendocrine tumor (NET) is one of malignant cancer and is identified with high morbidity and mortality rates around the world. With indigent clinical outcomes, potential biomarkers for diagnosis, prognosis and drug target are crucial to explore. The aim of this study is to examine the gene expression module of NET and to identify potential diagnostic and prognostic biomarkers as well as to find out new drug target. The differentially expressed genes (DEGs) identified from GSE65286 dataset was used for pathway enrichment analyses and gene ontology (GO) enrichment analyses and protein - protein interaction (PPI) analysis and module analysis. Moreover, miRNAs and transcription factors (TFs) that regulated the up and down regulated genes were predicted. Furthermore, validation of hub genes was performed. Finally, molecular docking studies were performed. DEGs were identified, including 453 down regulated and 459 up regulated genes. Pathway and GO enrichment analysis revealed that DEGs were enriched in sucrose degradation, creatine biosynthesis, anion transport and modulation of chemical synaptic transmission. Important hub genes and target genes were identified through PPI network, modules, target gene - miRNA network and target gene - TF network. Finally, survival analyses, receiver operating characteristic (ROC) curve and RT-PCR validated the significant difference of ATP1A1, LGALS3, LDHA, SYK, VDR, OBSL1, KRT40, WWOX, NINL and PPP2R2B between metastatic NET and normal controls. In conclusion, the DEGs and hub genes with their regulatory elements identified in this study will help us understand the molecular mechanisms underlying NET and provide candidate targets for future research.

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Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk

Cited by 11 publications

References 18 publications

The role of the histoblood ABO group in cancer

The role of the histoblood ABO group in cancer

FUT2 genetic variants as predictors of tumor development with hepatocellular carcinoma

Identification of key genes and associated pathways in neuroendocrine tumors through bioinformatics analysis and predictions of small drug molecules

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