Combination Treatment of Osteoporosis: A Clinical Review

Crandall, Carolyn J.

doi:10.1089/152460902753668420

Cited by 11 publications

(3 citation statements)

References 30 publications

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“…P4 administration resulted in increased T-cadherin expression, whereas E2, which had no effect alone, was shown to attenuate the stimulatory effect of P4, suggesting it is able to modulate Tcadherin transcription in vivo in response to cyclic changes in hormone levels. This is a significant finding in a bone cell model, since hormone-induced changes in bone structure and density contribute to significant morbidity in menopausal females (Crandall, 2002). Microarray analysis has also shown that T-cadherin is involved during fracture healing, suggesting that it has a role not only in bone formation, but also in the maintenance and turnover of mature bone tissue (Hadjiargyrou et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Regulation of T-cadherin by hormones, glucocorticoid and EGF

Bromhead

Miller

McDonald

2006

Gene

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Section: Discussionmentioning

confidence: 99%

Regulation of T-cadherin by hormones, glucocorticoid and EGF

Bromhead

Miller

McDonald

2006

Gene

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“…However, nandrolone has been used for the medical treatment of chronic diseases associated with a catabolic state such as burns, cornea healing, and osteoporosis [ 33 , 34 ], treatment of breast and prostate cancers [ 35 , 36 ], and, for its anti-anemic effects, treatment of male dialysis patients over the age of 50 [ 37 ]. ND is used in clinical practice to increase bone mineral mass, reduce bone loss, and decrease the incidence of fractures, with particular application to osteoporotic patients [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Nandrolone Decanoate in the Osseointegration of Dental Implants in a Rabbit Model: Histological and Micro-Radiographic Results

Lupi

Sassi

Addis³

et al. 2021

Materials

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Despite high rates of osseointegration in healthy patients, complex cases present an increased risk of osseointegration failure when treated with dental implants. Furthermore, if immediate loading of the implants is used, maximizing the response of the host organism would be desirable. Anabolic steroids, such as Nandrolone Decanoate (ND), are reported to have beneficial clinical effects on various bone issues such as osteoporosis and bone fractures. However, their beneficial effects in promoting osseointegration in dental implant placement have not been documented. The study aimed to examine histological changes induced by ND in experimental dental implants in rabbit models. Two dental implants were placed in the tibias of 24 adult rabbits. Rabbits were allocated to one of two groups: control group or test group. Rabbits in the latter group were given nandrolone decanoate (15 mg/kg, immediately after implant placement and after 1 week). Micro-radiographic and histological analyses were assessed to characterize the morphological changes promoted by the nandrolone decanoate use. Total bone volume and fluorescence were significantly higher in the control group after 2 weeks. Such a difference between the two groups might indicate that, initially, nandrolone lengthens the non-specific healing period characteristic of all bone surgeries. However, after the beginning of the reparative processes, the quantity of newly formed bone appears to be significantly higher, indicating a positive stimulation of the androgen molecule on bone metabolism. Based on micro-radiology and fluorescence microscopy, nandrolone decanoate influenced bone regeneration in the implant site. The anabolic steroid nandrolone decanoate affects the healing processes of the peri-implant bone and therefore has the potential to improve the outcomes of implant treatment in medically complex patients.

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“…At present, there are generally two major pharmacological approaches for the clinical treatment of osteoporosis. 3,4 One is for anabolic agents for stimulating bone formation, and another is anti-resorptive agents for inhibiting the bone resorption. 5,6 Among all these agents, strontium renalate has received significant attention due to its dual effects on stimulating bone formation and inhibiting bone resorption.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of strontium/calcium containing poly(γ-glutamic acid) – organosiloxane fibrous hybrid materials for osteoporotic bone regeneration

Gao

Zhao

et al. 2018

RSC Adv.

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Recent researches have proved that combination of several therapeutic metal ions, such as silicate (Si), calcium (Ca), strontium (Sr) and so on, with biomaterials may have promising effects for stimulating bone regeneration. In the present study, the Sr/Ca containing silicate hybrid materials (Sr/Ca-g-PGA-silica) with a mimetic native extracellular matrix (ECM) structure have been developed by electrospinning. With the aim to promote the solubility of g-PGA in aqueous-based solution and introduce Sr/Ca elements into the prepared hybrid materials, SrCO 3 and CaCO 3 were employed due to their nontoxicity and no by-products during chemical reaction between g-PGA and SrCO 3 /CaCO 3 . Results of SEM, EDX and elemental mapping images showed that Sr and Ca have been successfully incorporated into the prepared fibrous hybrid materials with homogeneous dispersion. Results of ICP-AES revealed that there was continuous Si, Sr and Ca ion release behavior of Sr/Ca-g-PGA-silica hybrid materials in Tris-HCl buffer solution and the Si ions release rate can be tailored by adjusting the molar ratio of Sr to Ca. Immersion of Sr/Ca-g-PGA-silica hybrid materials in a simulated body fluid (SBF) resulted in the formation of an apatite-like surface layer within 3 days, indicating their excellent bioactivity. In addition, the prepared Sr/Ca-g-PGA-silica hybrid materials supported the proliferation and alkaline phosphatase (ALP) activity of osteoblast in vitro, showing their good biocompatibility. Altogether, the results indicated that the prepared Sr/Ca-g-PGA-silica hybrid materials with an adjusted ionic release behavior have great potential for providing an excellent ECM for osteoporotic bone regeneration.

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Combination Treatment of Osteoporosis: A Clinical Review

Cited by 11 publications

References 30 publications

Regulation of T-cadherin by hormones, glucocorticoid and EGF

Regulation of T-cadherin by hormones, glucocorticoid and EGF

The Impact of Nandrolone Decanoate in the Osseointegration of Dental Implants in a Rabbit Model: Histological and Micro-Radiographic Results

Fabrication of strontium/calcium containing poly(γ-glutamic acid) – organosiloxane fibrous hybrid materials for osteoporotic bone regeneration

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