Combination therapy with vitamin D analogues

Lamba, Sonika; Lebwohl, Mark

doi:10.1046/j.1365-2133.2001.144s58027.x

Cited by 34 publications

(8 citation statements)

References 31 publications

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“…Findings for some poor responding patient categories make a strong case for trying such alternatives instead of digressing guidelines resorting to over treatment or under treatment with traditional drugs. Vitamin D3 analogues are reported to be as effective as steroids and yield a synergistic benefit in psoriasis, reducing required mutual doses39. Tazarotene, the newer retinoid is especially inhibitory to the dermal infiltration of inflammatory cells40.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Conventional Drug Therapy of Plaque Psoriasis in the Context of Consensus Guidelines: A Prospective Observational Study in 150 Patients

2013

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BackgroundEvidence for superior outcome by adhering to therapy guidelines is imperative to their acceptance and adaptation for the optimal management of disease variants.ObjectiveComparative study of prospective outcomes in simultaneous consideration of independent variables in groups of 150 patients of plaque psoriasis either treated adhering to or in digression of standard guidelines.MethodsThe psoriasis area severity index (PASI) and the dermatology life quality index (DLQI), prior to and after three months of uninterrupted therapy were examined in treatment groups among 150 patients. Recovery rates of 75% or more in PASI were compared. Independent variables were also examined for their bearing on the outcome.ResultsThe vast majority was early onset disease phenotype. All three treatment regimens when administered in adherence to the guidelines yielded significantly superior rates of defined recovery both in PASI and DLQI. Compromise of the therapeutic outcome appeared in high stress profiles, obesity, female sex and alcohol, tobacco or smoking habit.ConclusionConventional drug therapy of plaque psoriasis yields superior outcome by adhering to the consensus guidelines. Psychiatric address to stress must be integral and special considerations for phenotypic/syndromic variants is emphasized for effective therapy of psoriasis.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Conventional Drug Therapy of Plaque Psoriasis in the Context of Consensus Guidelines: A Prospective Observational Study in 150 Patients

2013

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“…The effectiveness of calcipotriol in the treatment of psoriasis has primarily been attributed to its effects on epidermal proliferation and differentiation/keratinisation [10-12] although the effects on skin infiltrating T cells are relevant to its mode of action [13,14]. Calcipotriol has been shown to reduce CD3, CD4, CD8 and CD45RO positive T-cells in psoriatic skin [15].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model

et al. 2009

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The aim of the present study was to compare the effects of Daivobet® and calcipotriol on clinical score and biomarker responses in a modified version of the Scholtz-Dumas psoriasis plaque assay. Furthermore, it was the aim to compare the effects of calcipotriol and betamethasone in the murine psoriasis xenograft model. Twenty four patients with psoriasis were treated topically once daily for three weeks, whereas the grafted mice were treated for four weeks. Clinical responses were scored twice weekly and biopsies were taken at the end of each study to analyse for skin biomarkers by histology and immunohistochemistry. The results clearly demonstrate effects on both clinical signs and biomarkers. In the patient study the total clinical score was reduced significantly with both Daivobet® and calcipotriol. Both treatments reduced epidermal thickness, Ki-67 and cytokeratin 16 expression. T cell infiltration was significantly reduced by Daivobet® but only marginally by calcipotriol. Both treatments showed strong effects on the epidermal psoriatic phenotype.Results from the xenograft model essentially showed the same results. However differences were observed when investigating subtypes of T cells.The study demonstrates the feasibility of obtaining robust biomarker data in the psoriasis plaque test that correlate well with those obtained in other clinical studies. Furthermore, the biomarker data from the plaque test correlate with biopsy data from the grafted mice.

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“…[108,109] There was a reduction of CD3 + CD4 + CD8 + memory T cells in psoriatic skin [110] as well as significant reduction in biomarkers of epidermal proliferation, differentiation, and lymphocyte infiltration. [110][111][112] Likewise, in a study with K252a, a high affinity NGF-R blocker, we have shown that within 2 weeks of administration in SCID mouse psoriatic xenograft model, it reduced clinical, immunological as well as pathological characteristics of psoriasis.…”

Section: Drugs Targeting Proliferation and Differentiationmentioning

confidence: 96%

Severe combined immunodeficiency mouse-psoriatic human skin xenograft model: A modern tool connecting bench to bedside

Kundu-Raychaudhuri

Datta-Mitra

Abria

et al. 2014

Indian J Dermatol Venereol Leprol

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Psoriasis is a multifactorial chronic inflammatory disease. Research into the pathogenesis of this disease is hindered by the lack of a proper animal model. Over the past two decades, many scientists were involved in the development of animal models that nearly mirror the immunopathogenesis of psoriasis. One such model, which has opened doors to the study of molecular complexities of psoriasis as well as its treatment, is the severe combined immunodeficiency (SCID) mouse-human skin chimera model. This model not only mirrors the clinical and histopathological features of psoriasis but also help in the study of cell proliferation, angiogenesis, function of T cells, neurogenic inflammation and cytokines involved in inflammatory reactions. In this article, we have reviewed the prospects and the limitations of the SCID mouse model of psoriasis.

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Combination therapy with vitamin D analogues

Cited by 34 publications

References 31 publications

Effectiveness of Conventional Drug Therapy of Plaque Psoriasis in the Context of Consensus Guidelines: A Prospective Observational Study in 150 Patients

Effectiveness of Conventional Drug Therapy of Plaque Psoriasis in the Context of Consensus Guidelines: A Prospective Observational Study in 150 Patients

Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model

Severe combined immunodeficiency mouse-psoriatic human skin xenograft model: A modern tool connecting bench to bedside

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