Combination therapy using nanomaterials and stem cells to treat spinal cord injuries

Zarepour, Arezou; Bal‐Öztürk, Ayça; Irmak, Duygu Koyuncu; Yaşayan, Gökçen; Gökmen, Aylin; Karaöz, Erdal; Zarepour, Atefeh; Zarrabi, Ali; Mostafavi, Ebrahim

doi:10.1016/j.ejpb.2022.07.004

Cited by 10 publications

(8 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, treatments with NSCs present challenges in terms of their regulation and evaluation of outcomes, including survival, distribution, differentiation, and integration. Long-term therapies generally focus on secondary damage alterations such as neuroinflammation and maladaptive plasticity, aiming at preserving the tissue and multiplying the production of exogenous NSCs to increase regeneration ( 26 , 81 ). The combination of nanotechnology with stem cells is continuously developing and has shown that it can favor clinical and therapeutic diagnosis in various CNS diseases.…”

Section: Recent Advances In the Combination Of Cellular Therapy With ...mentioning

confidence: 99%

Recent advances in the combination of cellular therapy with stem cells and nanoparticles after a spinal cord injury

et al. 2023

View full text Add to dashboard Cite

BackgroundCurrently, combined therapies could help to reduce long-term sequelae of spinal cord injury (SCI); stem cell therapy at the site of injury in combination with other therapies has shown very promising results that can be transferred to the clinical field. Nanoparticles (NPs) are versatile technologies with applications to medical research for treatments of SCI since they could deliver therapeutic molecules to the target tissue and may help to reduce the side effects of non-targeted therapies. This article's purpose is to analyze and concisely describe the diverse cellular therapies in combination with NPs and their regenerative effect after SCI.MethodsWe reviewed the literature related to combinatory therapy for motor impairment following SCI that has been published by Web of Science, Scopus, EBSCO host, and PubMed databases. The research covers the databases from 2001 to December 2022.ResultAnimal models of SCI have shown that the combination of NPs plus stem cells has a positive impact on neuroprotection and neuroregeneration. Further research is required to better understand the effects and benefits of SCI on a clinical level; therefore, it is necessary to find and select the most effective molecules that are capable of exacerbating the neurorestorative effects of the different stem cells and then try them out on patients after SCI. On the other hand, we consider that synthetic polymers such as poly [lactic-co-glycolic acid] (PLGA) could be a candidate for the design of the first therapeutic strategy that combines NPs with stem cells in patients with SCI. The reasons for the selection are that PLGA has shown important advantages over other NPs, such as being biodegradable, having low toxicity levels, and high biocompatibility; In addition, researchers could control the release time and the biodegradation kinetics, and most importantly, it could be used as NMs on other clinical pathologies (12 studies on www.clinicaltrials.gov) and has been approved by the Federal Food, Drug, and Cosmetic Act (FDA).ConclusionThe use of cellular therapy and NPs may be a worthwhile alternative for SCI therapy; however, it is expected that the data obtained from interventions after SCI reflect an important variability of molecules combined with NPs. Therefore, it is necessary to properly define the limits of this research to be able to continue to work on the same line. Consequently, the selection of a specific therapeutic molecule and type of NPs plus stem cells are crucial to evaluate its application in clinical trials.

show abstract

Section: Recent Advances In the Combination Of Cellular Therapy With ...mentioning

confidence: 99%

Recent advances in the combination of cellular therapy with stem cells and nanoparticles after a spinal cord injury

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Combining nanomaterials with SC is another innovative approach for therapeutic applications after SCI. Nanomaterial appears to be a promising platform for culturing the cells and SC-nanomaterial combination may hold further benefits for the patients, as suggested by a recent review of Zarepour et al [ 62 ]. The authors analyzed the efficacy of nanomaterials in detail, both organic and inorganic, at multiple levels: From their carriers of therapeutic agents, anti-inflammatory and neurotrophic, but also in the form of scaffolds as in the field of hydrogels for tissue regeneration.…”

Section: From Pharmacological To Stem Cell Interventionsmentioning

confidence: 99%

“…Additionally, there are concerns about the expense of developing adult stem cells, which seem to be the most effective in influencing regeneration after SCI. Another interesting area of research combining novel approaches is the application of nanomaterials, which could act as carriers for therapeutic agents or as platforms for culturing the cells [ 62 ].…”

Section: From Pharmacological To Stem Cell Interventionsmentioning

confidence: 99%

Integrated Neuroregenerative Techniques for Plasticity of the Injured Spinal Cord

et al. 2022

View full text Add to dashboard Cite

On the slow path to improving the life expectancy and quality of life of patients post spinal cord injury (SCI), recovery remains controversial. The potential role of the regenerative capacity of the nervous system has led to numerous attempts to stimulate the SCI to re-establish the interrupted sensorimotor loop and to understand its potential in the recovery process. Numerous resources are now available, from pharmacological to biomolecular approaches and from neuromodulation to sensorimotor rehabilitation interventions based on the use of various neural interfaces, exoskeletons, and virtual reality applications. The integration of existing resources seems to be a promising field of research, especially from the perspective of improving living conditions in the short to medium term. Goals such as reducing chronic forms of neuropathic pain, regaining control over certain physiological activities, and enhancing residual abilities are often more urgent than complete functional recovery. In this perspective article, we provide an overview of the latest interventions for the treatment of SCI through broad phases of injury rehabilitation. The underlying intention of this work is to introduce a spinal cord neuroplasticity-based multimodal approach to promote functional recovery and improve quality of life after SCI. Nonetheless, when used separately, biomolecular therapeutic approaches have been shown to have modest outcomes.

show abstract

“…Studies have shown that transplanted MSCs exhibit neuroprotective function and can increase the proportion of intact tissue in SCI [ [8] , [9] , [10] ]. Over the years, many different types of nanomedicines, including liposomes, polymers, micelles, and antibodies, have been developed for advanced cell therapies, and there has been substantial evidence that these submicron-sized carrier materials can improve the balance between efficacy and toxicity of therapeutic interventions [ [11] , [12] , [13] , [14] , [15] ]. Although some progress has been made with nanomedicine carriers, there are still shortcomings, such as a lack of inherent targeting and rapid clearance by immune cells [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair

Hua,

Zhao,

et al. 2024

Bioactive Materials

View full text Add to dashboard Cite

Combination therapy using nanomaterials and stem cells to treat spinal cord injuries

Cited by 10 publications

References 140 publications

Recent advances in the combination of cellular therapy with stem cells and nanoparticles after a spinal cord injury

Recent advances in the combination of cellular therapy with stem cells and nanoparticles after a spinal cord injury

Integrated Neuroregenerative Techniques for Plasticity of the Injured Spinal Cord

ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair

Contact Info

Product

Resources

About