Combination Therapy Use and Associated Events in Clinical Practice Following Dissemination of Trial Findings: A De-Implementation Study Using Interrupted Time Series Analysis

Optimizing TSH testing: minimizing overdiagnosis and unnecessary interventions

“…However, it is essential to recognize that education alone may not suffice to change deeply entrenched practices [1]. Research indicates that relying solely on education for de-implementation often yields limited effectiveness, emphasizing the need for a multifaceted, multi-level approach in current strategies, which has shown to yield more promising results [51].…”

“…Research indicates that relying solely on education for de-implementation often yields limited effectiveness, emphasizing the need for a multifaceted, multi-level approach in current strategies, which has shown to yield more promising results [51]. Moreover, the implementation process tends to accelerate significantly when clear policies and effective communication channels are established among research, Pharmacy Benefit Management (PBM) Services, and clinical practice [1]. Therefore, it is critical to seamlessly integrate educational strategies into a comprehensive framework to ensure their effectiveness.…”

“…The journey from clinical trial discoveries to their practical application in healthcare is remarkably slow, often taking up to 17 years. This slow process reveals a significant healthcare paradox: the hesitancy to adopt proven interventions while outdated or less effective practices continue, particularly in thyroid health management [1,2]. This situation points to a significant gap between knowledge generation and its application, underscoring a critical area for improvement across all medical areas, including endocrinology [3].…”