Combination therapy of the granulocyte colony stimulating factor and intravenous lipid emulsion protect the hippocampus after global ischemia in rat: focusing on CA1 region

Rasouli, Babak; Ghahari, Laya; Safari, Manouchehr; Shahroozian, Ebrahim; Naeimi, Saeideh

doi:10.1007/s11011-020-00579-2

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…This suggests that the elevated secretion of G-CSF may have anti-inflammatory effects. A previous study has shown that intravenous lipid emulsion and G-CSF each have neuroprotective effects and can effectively improve memory and learning in an ischemic rat model, with a combination of the lipid emulsion and G-CSF being more effective than either alone ( 26 ). G-CSF is a glycoprotein produced by macrophages and endothelial cells, which stimulates the bone marrow to produce granulocytes and stem cells.…”

Section: Discussionmentioning

confidence: 99%

Modulation of secretory factors by lipofundin contributes to its anti‑neuroinflammatory effects

Chen,

Hu,

Jiang

et al. 2024

Exp Ther Med

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As the global population ages, the prevalence of neuroinflammatory diseases such as Alzheimer's disease, Parkinson's disease and stroke continues to increase. Therefore, it is necessary to develop preventive and therapeutic methods against neuroinflammatory diseases. Lipofundin is a lipid emulsion commonly used in clinical anesthetic solvents and nutritional supplements. Lipid emulsions have been shown to possess anti-inflammatory properties. However, the potential beneficial effect of lipofundin against neuroinflammation requires elucidation. In the present study, two cell models were used to investigate the efficacy of lipofundin against neuroinflammation. In the first model, BV2 mouse microglial cells were treated with lipopolysaccharide (LPS) to induce nitric oxide (NO) production as a model of neuroinflammation. In the second model, HMC3 human microglial were activated by LPS, and changes in the secretion of factors associated with inflammation were analyzed using Luminex xMAP ® technology. Griess assay results revealed that lipofundin significantly prevented and treated LPS-induced NO production. An anti-neuroinflammatory effect was also observed in HMC3 cells, where lipofundin exhibited excellent preventive and therapeutic properties by reducing the LPS-induced expression and secretion of interleukin-1β. Notably, lipofundin also promoted the secretion of certain growth factors, suggesting a potential neuroprotective effect. These results demonstrate that, in addition to its role as a solvent for drugs and nutritional support, lipofundin may also have beneficial effects in alleviating the progression of neuroinflammation. These findings may serve as an important reference for future translational medicine applications.

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Section: Discussionmentioning

confidence: 99%

Modulation of secretory factors by lipofundin contributes to its anti‑neuroinflammatory effects

Chen,

Hu,

Jiang

et al. 2024

Exp Ther Med

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“…The head of the hippocampus is mainly composed of the CA1 region with a complete signal output loop [ 33 , 34 ]. As a functional core area, the CA1 region is particularly sensitive to ischemia [ 35 , 36 ]. Moreover, enduring forms of memory rely on the structural connectivity of synapses that typically require activity-dependent expression of the activity-regulated cytoskeleton-associated protein (Arc).…”

Section: Introductionmentioning

confidence: 99%

Intraoperative Hypothermia Induces Vascular Dysfunction in the CA1 Region of Rat Hippocampus

et al. 2022

Brain Sciences

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Intraoperative hypothermia is very common and leads to memory decline. The hippocampus is responsible for memory formation. As a functional core area, the cornu ammonis 1 (CA1) region of the hippocampus contains abundant blood vessels and is susceptible to ischemia. The aim of the study was to explore vascular function and neuronal state in the CA1 region of rats undergoing intraoperative hypothermia. The neuronal morphological change and activity-regulated cytoskeleton-associated protein (Arc) expression were evaluated by haematoxylin-eosin staining and immunofluorescence respectively. Histology and immunohistochemistry were used to assess vascular function. Results showed that intraoperative hypothermia inhibited the expression of vascular endothelial growth factor and endothelial nitric oxide synthase, and caused reactive oxygen species accumulation. Additionally, the phenotype of vascular smooth muscle cells was transformed from contractile to synthetic, showing a decrease in smooth muscle myosin heavy chain and an increase in osteopontin. Ultimately, vascular dysfunction caused neuronal pyknosis in the CA1 region and reduced memory-related Arc expression. In conclusion, neuronal disorder in the CA1 region was caused by intraoperative hypothermia-related vascular dysfunction. This study could provide a novel understanding of the effect of intraoperative hypothermia in the hippocampus, which might identify a new research target and treatment strategy.

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Long period changes of hippocampal diffusion kurtosis imaging and its correlation with cognitive dysfunction after incomplete cerebral ischemia–reperfusion in rats

Fu,

Guan,

Zuo

2023

Exp Brain Res

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Combination therapy of the granulocyte colony stimulating factor and intravenous lipid emulsion protect the hippocampus after global ischemia in rat: focusing on CA1 region

Cited by 3 publications

References 30 publications

Modulation of secretory factors by lipofundin contributes to its anti‑neuroinflammatory effects

Modulation of secretory factors by lipofundin contributes to its anti‑neuroinflammatory effects

Intraoperative Hypothermia Induces Vascular Dysfunction in the CA1 Region of Rat Hippocampus

Long period changes of hippocampal diffusion kurtosis imaging and its correlation with cognitive dysfunction after incomplete cerebral ischemia–reperfusion in rats

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