Combination Therapy Of Tadalafil And Pentoxifylline In Severe Erectile Dysfunction; A Prospective Randomized Trial

Abstract

Both tadalafil and combination of Tadalafil + Pentoxifylline improve erectile function in patients of ED. Patients with severe ED showed much significant improvement in erectile function with combination therapy.

A Small Group Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy of Daily Pentoxifylline in the Management of Patients With Erectile Dysfunction with Suboptimal Treatment Response to Sildenafil

“…Patients with severe ED in particular also experienced much greater improvements in EF with combination therapy. 16 Compared to our trial, the significant improvement in ED with combination therapy may be due to tadalafil's longer half-life (17.50 hours) compared to sildenafil (4À5 hours), but more randomized studies will be required to review this.…”

“…In terms of the incidence of AEs between the 2 treatment arms, there were no significant differences. 12,16 Our trial reflected a relative high rate of noncompliance. 33% of the trial patients had a balance of >30 of 168 caplets dispensed.…”

“…In a more recent randomized prospective trial by Kumar et al 16 involving 237 men with ED, patients who received tadalafil/pentoxifylline combination therapy had statistically significant improvements in the IIEF scores after 8 weeks as compared to those who took single agent tadalafil. Patients with severe ED in particular also experienced much greater improvements in EF with combination therapy.…”

“…More recent studies have shown results of better efficacy with combination therapy as opposed to monotherapy with PDE-5 inhibitors. 12,16 In 2007, a pilot study by Ozdal et al 12 showed that although the mean IIEF score was higher after both S-only treatment and combination treatment (SþP) compared to pretreatment scores, the increase in the IIEF score was higher in the combination therapy group by 4 (P < .001). In this pilot study, 68 patients received S only treatment for 4 weeks and were subjected to the IIEF questionnaire and a washout period of 4 weeks.…”

Understanding the cellular basis and pathophysiology of Peyronie’s disease to optimize treatment for erectile dysfunction

“…They observed a slight improvement in IIEF scores in men with severe ED when compared to tadalafil alone. The clinical relevance is unclear and further studies need to be done to look at this further ( 65 ).…”