Combination Therapy of Sucralfate and Ranitidine, Compared with Sucralfate Monotherapy, in Patients with Peptic Reflux Esophagitis

Abstract

A double-blind, multicenter, randomized study was performed in 75 patients with endoscopically documented reflux esophagitis. Patients were randomly given 1 g sucralfate four times a day or the combination of sucralfate three times a day and 300 mg ranitidine after dinnertime. Endoscopy was performed at the beginning of the study, after 8 weeks, and, if, the reflux esophagitis was not healed, after 16 weeks. Four patients had to be excluded from evaluation; 71 patients could therefore be evaluated. Both groups showed symptomatic improvement to similar extents. Endoscopy showed symptomatic improvement in 67% of the patients treated with sucralfate and in 74% of the combination therapy group. Complete healing or Savary-Miller stage 1 was seen in 26.5% and in 31.4%, respectively. We conclude that sucralfate monotherapy in patients with milder forms of reflux esophagitis is comparable with a combination of sucralfate during the day and ranitidine after dinnertime. This study does not support the commonly used combination of sucralfate and H2-receptor antagonists in reflux esophagitis.

Suspected clindamycin-associated oesophageal injury in cats: Five cases

“…Optimal medical management for oesophagitis has not been determined in human or veterinary medicine. Controlled clinical trials in humans are limited and often conflicting (Vermeijden et al 1992, Vigneri et al 1995. In this series, medical management was instituted on a case by case basis at the discretion of the clinician.…”

7 Day Comparative Effectiveness in Heartburn Relief and Endoscopic Healing. Randomized Controlled Trial using Omeprazole, Ranitidine, Antacids and Esolgafate, A Pre-Polymerized Cross-Linked Sucralfate (PCLS) Barrier Therapy

“…The expected experience of standard sucralfate for symptomatic relief of eGERD is that 7 days would be insufficient time to provide symptomatic relief on par with standard of care therapeutic options. Specifically, Vermeijden et al [39] reported the best known outcomes for sucralfate in the treatment of eGERD. Using standard sucralfate, patients required 56 days to achieve 80% symptomatic relief.…”

“…In this trial, pre-polymerized sucralfate required only 7 days for 80% symptomatic relief. Additionally, Vermeijden et al [39] observed that in 56 days, 4 grams daily of standard sucralfate (or 224 grams) was required to achieve a healing rate of 68%. In this trial using 3 grams per day for 7 days (or 21 grams) of pre-polymerized sucralfate suspension barrier, 80% complete healing and 20% partial healing was achieved.…”

Efficacy and Safety of AlbisD Compared With Omeprazole 20 mg in Patients With Non-erosive Reflux Disease: A Randomized, Open-label, Active-controlled, Pilot Study

“…21 It is even as effective as H2RAs in improving GERD symptoms and healing erosive esophagitis. 22,23 Third, the other component of AlbisD, bismuth, can inhibit certain bacterial activities. However, its inhibitory effect on bacteria such as H. pylori may not have played an important role in improving the symptoms of the study patients, because GERD or NERD are not closely associated with H. pylori status.…”