Combination Therapy of Polymyxin B and Amikacin for Community-Acquired Pseudomonas aeruginosa Pneumonia with MODS in a Previously Healthy Patient: A Case Report

Abstract

Background: Pseudomonas aeruginosa (P. aeruginosa) is an uncommon but fatal causative pathogen for community-acquired pneumonia (CAP). Few case reports described the previously healthy individuals with CAP caused by P. aeruginosa. Case Presentation: A 67-year-old male farmer was referred to our hospital with a 6-day history of fever and shortness of breath. The radiologic findings revealed a dense consolidation site in the right lung, considering infection lesion, accompanying with mediastinal and right hilar lymphadenopathy. Sputum sample results showed P. aeruginosa and multidrugresistant Acinetobacter baumannii. The combination of polymyxin B and amikacin was given to him based on the lab results, the manifestations of the patient were alleviated and he returned to his home after a 35-day hospitalization. Conclusion:We need to keep close attention to community-acquired P. aeruginosa pneumonia due to its high mortality, further studies are needed to identify the infectious source, effective examination, and optimal therapy including medications and duration.

Molecular Epidemiology of Community-Acquired Methicillin-Resistant Staphylococcus aureus and Clinical Characteristics of Different Sites of Infection

“…Pneumonia caused by CA-MRSA is prone to be secondary to influenza virus infection. 31 , 32 In our research, 37.5% of CA-MRSA pneumonia cases had an influenza virus infection, and 83.3% caused severe pneumonia. Before we recognized CA-MRSA, necrotizing fasciitis, necrotizing pneumonia, and severe sepsis caused by S. aureus were rarely reported; however, there are many reports of CA-MRSA infections now.…”

Late diagnosis of X‐linked hyper‐IgM syndrome presenting as community‐acquired Pseudomonas aeruginosa pneumonia‐related septic shock

“…P. aeruginosa is an important cause of nosocomial infections and community‐acquired infections in immunocompromised patients and patients with structural lung disease. Community‐acquired P. aeruginosa infections are rare but have an acute onset, rapid progression, and lead to the development of short‐term shock 1 . The patient in our study diagnosed severe CAP due to P. aeruginosa and also progressed to septic shock quickly.…”

“…Communityacquired P. aeruginosa pneumonia-related septic shock confirmed. The invasive progress raised our suspicion of underlying immunodeficiencies 1. The patient in our study diagnosed severe CAP due to P. aeruginosa and also progressed to septic shock quickly.…”

“…Pseudomonas aeruginosa , a gram‐negative aerobic bacterium, is an uncommon but fatal causative pathogen for community‐acquired pneumonia (CAP) 1 . X‐linked hyper‐IgM syndrome (XHIGM; HIGM1; OMIM:308230) is one type of inborn errors of immunity (IEIs), resulting from defects in the CD40 ligand/CD40 signaling pathways leading to impairment of immunoglobulin isotype switching in B cells.…”

Late diagnosis of X-linked hyper-IgM syndrome presenting as community-acquired pseudomonas aeruginosa pneumonia-related septic shock

“…The typical patient presenting with nosocomial P. aeruginosainfection is mechanically ventilated, has slowly progressive lung infiltrates, and has been colonized for days 6 . Community-acquired P. aeruginosa infections are rare but have an acute onset, rapid progression, and lead to the development of short-term shock 7,8 . The patient in our study diagnosed severe community-acquired pneumonia (CAP) due to P. aeruginosa and also progressed to septic shock quickly.…”