Combination therapy of human adipose-derived stem cells and basic fibroblast growth factor hydrogel in muscle regeneration

Hwang, Ji Hye; Kim, In Gul; Piao, Shilong; Jung, Ae Ryang; Lee, Jun-Young; Парк, Ки Донг; Lee, Ji Youl

doi:10.1016/j.biomaterials.2013.04.049

Cited by 62 publications

(58 citation statements)

References 28 publications

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“…The most striking result was the reduction of fibrosis to only roughly 20% and the recovery of functional parameters reaching 89% of uninjured muscles. Indicators of regenerative events (immature myofibers, reinnervation, and neovascularization) were also significantly improved [83]. When associated to Matrigel TM , early improvements were observed.…”

Section: Msc-biomaterials Systems For In Vivo Skeletal Muscle Regeneramentioning

confidence: 65%

“…AT-MSCs also contribute to enhanced regeneration, reducing fibrosis and improving histological and functional features after only 4 weeks. However MSCs alone did improve the process, their association to a biomaterial vehicle and bioactive cues further enhanced those results, as detailed later in this section [83].…”

Section: Evidence On the Application Of Mscs For In Vivo Skeletal Musmentioning

confidence: 82%

“…Further, in vivo applications suggest that, to variable extent, MSCs are capable of integrating host muscular tissues, being identifiable at the lesion site shortly after implantation (Figure 2) [54,67,[75][76][77][83][84][85]. The long time observation of administered MSCs in host muscle has also been reported, even when delivered systemically [2,4].…”

Section: Evidence On the Application Of Mscs For In Vivo Skeletal Musmentioning

confidence: 94%

“…This in situ forming gel was loaded with a prosurvival growth factor (bFGF), sustaining controlled release for up to 3 weeks. In vivo, the loaded hydrogel significantly improved contractile force of healing muscles, reduced local fibrosis, and increased multinucleated regenerating myofibers and neurovascular structures on site [83]. Stem cell implantation is a possible strategy to enhance the recovery rates whether they are delivered alone or in association to biomaterial scaffolds.…”

Section: Msc-biomaterials Systems For In Vivo Skeletal Muscle Regeneramentioning

confidence: 99%

“…These biomaterial scaffolds are also valuable in recreating an advantageous mechanical and chemical microenvironment for the proliferation and differentiation of resident or delivered progenitors [8]. In addition, these matrices may act as (as in the case of ECM) [93] or be modified/loaded with bioactive signaling molecules participating in the repair process [83].…”

Section: Msc-biomaterials Systems For In Vivo Skeletal Muscle Regeneramentioning

confidence: 99%

See 4 more Smart Citations

Trends in Mesenchymal Stem Cells' Applications for Skeletal Muscle Repair and Regeneration

Caseiro¹,

Pereira²,

Bártolo³

et al. 2015

Progress in Stem Cell Transplantation

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Skeletal muscle injuries are quite frequent in traumatic scenarios, such as war injuries or road-or work-related accidents. The skeletal muscle has good regenerative ability, but the extent or recurrence of muscle injury might impair complete structural and functional recovery. Severe tissue loss overwhelms skeletal muscle´s intrinsic regenerative capabilities and culminates in the development of noncontractile fibrous tissue scar. Conservative RICE -based and surgical treatments show limited efficacy in terms of improving these severe cases outcomes, pressing the need for new approaches on skeletal muscle's therapy. Since the first suggestions of the potential of mesenchymal stem cells for regenerative medicine and tissue engineering, many applications have been explored for a variety of tissues and diseases, including the skeletal muscle, which is the focus of this literature review.

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Section: Msc-biomaterials Systems For In Vivo Skeletal Muscle Regeneramentioning

confidence: 65%

Section: Evidence On the Application Of Mscs For In Vivo Skeletal Musmentioning

confidence: 82%

Section: Evidence On the Application Of Mscs For In Vivo Skeletal Musmentioning

confidence: 94%

Section: Msc-biomaterials Systems For In Vivo Skeletal Muscle Regeneramentioning

confidence: 99%

Section: Msc-biomaterials Systems For In Vivo Skeletal Muscle Regeneramentioning

confidence: 99%

See 3 more Smart Citations

Trends in Mesenchymal Stem Cells' Applications for Skeletal Muscle Repair and Regeneration

Caseiro¹,

Pereira²,

Bártolo³

et al. 2015

Progress in Stem Cell Transplantation

View full text Add to dashboard Cite

show abstract

Oxidoreductase‐Initiated Radical Polymerizations to Design Hydrogels and Micro/Nanogels: Mechanism, Molding, and Applications

Wang

Chen

et al. 2018

Advanced Materials

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Due to their 3D cross-linked networks and tunable physicochemical properties, polymer hydrogels with different sizes are applied widely in tissue engineering, drug-delivery systems, pollution regulation, ionic conducting electrolytes, agricultural drought-resistance, cosmetics, and the food industry. Novel, environmentally friendly, and efficient oxidoreductase-initiated radical polymerizations to design hydrogels and micro/nanogels have gained increasing attention. Herein, the recent advances on the use of novel enzyme-initiated systems for hydrogel polymerization, including the mechanisms, and molding of polymeric and hybrid-polymeric networks are reviewed. Preliminary progress related to interfacial enzymatic polymerization for the generation of hybrid micro/nanogels is introduced as an emerging initiating approach. In addition, certain biological applications in tissue engineering, bioimaging, and therapy are demonstrated step by step. Finally, some perspectives on the safety profile of enzymatic formed hydrogels, new enzymatic systems, and potential theranostic applications are discussed.

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Biomaterial and stem cell‐based strategies for skeletal muscle regeneration

Dunn

Talovic

Patel

et al. 2019

Journal Orthopaedic Research

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Adult skeletal muscle can regenerate effectively after mild physical or chemical insult. Muscle trauma or disease can overwhelm this innate capacity for regeneration and result in heightened inflammation and fibrotic tissue deposition resulting in loss of structure and function. Recent studies have focused on biomaterial and stem cell‐based therapies to promote skeletal muscle regeneration following injury and disease. Many stem cell populations besides satellite cells are implicated in muscle regeneration. These stem cells include but are not limited to mesenchymal stem cells, adipose‐derived stem cells, hematopoietic stem cells, pericytes, fibroadipogenic progenitors, side population cells, and CD133+ stem cells. However, several challenges associated with their isolation, availability, delivery, survival, engraftment, and differentiation have been reported in recent studies. While acellular scaffolds offer a relatively safe and potentially off‐the‐shelf solution to cell‐based therapies, they are often unable to stimulate host cell migration and activity to a level that would result in clinically meaningful regeneration of traumatized muscle. Combining stem cells and biomaterials may offer a viable therapeutic strategy that may overcome the limitations associated with these therapies when they are used in isolation. In this article, we review the stem cell populations that can stimulate muscle regeneration in vitro and in vivo. We also discuss the regenerative potential of combination therapies that utilize both stem cell and biomaterials for the treatment of skeletal muscle injury and disease. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1246–1262, 2019.

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Combination therapy of human adipose-derived stem cells and basic fibroblast growth factor hydrogel in muscle regeneration

Cited by 62 publications

References 28 publications

Trends in Mesenchymal Stem Cells' Applications for Skeletal Muscle Repair and Regeneration

Trends in Mesenchymal Stem Cells' Applications for Skeletal Muscle Repair and Regeneration

Oxidoreductase‐Initiated Radical Polymerizations to Design Hydrogels and Micro/Nanogels: Mechanism, Molding, and Applications

Biomaterial and stem cell‐based strategies for skeletal muscle regeneration

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