Combination Therapy of Epidermal Graft and Systemic Corticosteroid for Vitiligo

Triple combination of systemic corticosteroids, excimer laser, and topical tacrolimus in the treatment of recently developed localized vitiligo

“…The resulting prayer marks are mainly distributed on the forehead, elbows, knees, and ankles ( Fig. 1A) 3 . In one reported case, the mark was on the nasal bridge 4 .…”

“…During Sajda, the forehead repeatedly comes into contact with the ground (especially with the prayer rug). These repeated and long periods of friction leads to skin changes such as thickening, hyperpigmentation, and lichenification [1][2][3][4] .…”

“…Other reported histological changes were basal cell hyperpigmentation, hyperkeratosis, and acanthosis. Cangiano et al 3 published a case report in which prayer marks were associated with the worsening of an underlying chronic disease. Sharma et al 2 also reported a case in which prayer marks appeared 2 months before an acute myocardial infarction.…”

“…Therefore, delay in treatment initiation may make treatment more difficult, and thus there is a strong need for early intervention for a successful treatment. Multiple combination modalities have been suggested, including topical agents and phototherapy, or systemic corticosteroid and surgery 3 . In this open pilot study, we investigated the efficacy of a triple combination treatment, consisting of systemic corticosteroids, excimer laser, and topical tacrolimus, in patients with recently developed localized vitiligo.…”

Advanced Treatment Modalities for Vitiligo

“…Next, connect a 60-mL syringe to the 20-mL syringe using a stopcock. 45 Epidermal suction blistering is highly effective, with a response rate of 83% to 90%, and has been shown to have an excellent side-effect profile, with mainly hyperpigmentation of the donor sites and imperfect color matching being reported. Other options include using an angiosterrometer, a modified gastric suction pump, or a double syringe device.…”