Combination Therapy (Monomycine and Methyluracil) in Leishmaniasis Cutis

Abstract

Fifty patients with leishmaniasis cutis were treated with 250,000 units of monomycine intramuscularly every 8 hours and 0.5 g of methyluracil orally twice daily for a total period of 10 days. The follow-up study of all the patients for a period of 12 months showed persistent effectiveness of the treatment without the appearance of any sign and symptom of the so-called metaleishmaniasis (leishmaniasis recidivans). This paper highlights our results of treatment of leishmaniasis cutis, especially the rapid reduction of inflammatory reaction, quick regression of the skin process, and the rapid formation of scar without significant cosmetic effect in comparison with the data available in the literature.

Cutaneous leishmaniasis: successful treatment with itraconazole

“…Antimonials, 2,10 rifampicin, 27 antimalarial, 3 dapsone, 28 amphotericin B, 2,3,10 iposomal amphotericin B, 10 cotrimoxazole, 29 allopurinol, 28 monomycineethyluracil, 30 metronidazole, 31 pentamidine, 2 miltefosine, 10 pentoxifiline, 32 or itraconazole. 7-10 Immunotherapy Vaccination, 2 "Leishmanization", 3 levamisole 3 or interferon-γ.…”