Combination therapy for unresectable primitive myxoid mesenchymal tumor of infancy: A story of cure

Durable disease control with apatinib, irinotecan and temozolomide in a case of metastatic primitive myxoid mesenchymal tumour of infancy

“…Memmot and colleagues reported an infiltrative tumour progressing on neoadjuvant therapy with vincristine, actinomycin and cyclophosphamide (VAC), but subsequently responding to ifosfamide and doxorubicin (ID), enabling complete resection. 8 Among PMMTI cases receiving systemic therapy with a report on outcome (n = 7), anthracyclinecontaining regimen (ID or VDC) appeared to be active, whereas VA/VAC did not. Nonetheless, acute and chronic toxicities from such regimen are worrisome, as in our case where life-threatening sepsis developed.…”

“…Currently, definitive PMMTI management is usually surgical excision, especially for localised cases, 5,8 without a consensus for treatment of unresectable and/or metastatic disease. Memmot and colleagues reported an infiltrative tumour progressing on neoadjuvant therapy with vincristine, actinomycin and cyclophosphamide (VAC), but subsequently responding to ifosfamide and doxorubicin (ID), enabling complete resection.…”