Combination therapy application of Abemaciclib with Doxorubicin in triple
negative breast cancer cell line MDA-MB-231
Tugce Nur Eralp,
Akin Sevinc,
Banu Mansuroglu
Abstract:Due to lack of clinical biomarkers, Triple Negative Breast Cancer (TNBC) is more likely to have spread to other tissues at time of diagnosis and therapy planning generally involves use of cytotoxic chemotherapy agents, such as Doxorubicin. We aimed to investigate possible advantages of using combination strategy using Doxorubicin alongside Abemaciclib. After determining the IC50 values for Doxorubicin (DOX) and Abemaciclib (ABE); CompuSyn and ComBenefit software were used to reveal the effect resulting from th… Show more
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