Combination Therapies with Thiazolidinediones are Associated with a Lower Risk of Acute Exacerbations in New-Onset COPD Patients with Advanced Diabetic Mellitus: A Nested Case-Control Study
Abstract:BACKGROUND: The effects of oral antihyperglycemic drugs (OADs) for T2DM on outcomes of co-existing COPD patients have been less concerned. We examined the association of combinational OADs and risk of AECOPD in T2DM patients with co-existing COPDMETHODS: A nested case-control study was conducted using data from the National Health Insurance Research Database of Taiwan. Among new-onset COPD-T2DM patients, 65,370 were prescribed with metformin and 2nd line OADs before the date of COPD onset. Each AECOPD case was… Show more
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