Combination Therapies in the Management of Large (≥ 5 cm) Hepatocellular Carcinoma: Microwave Ablation Immediately Followed by Transarterial Chemoembolization

Feasibility and Efficacy of Microwave Ablation Combined with Iodine-125 Seed Implantation in Local Control of Recurrent Retroperitoneal Liposarcomas: Initial Clinical Experience

“…All patients tolerated the procedures well; no procedure‐related deaths occurred, and no patients requested to immediately stop treatment during these procedures. Complications of MWA were mild to moderate and easy to handle, as previous studies reported . Post‐ablation pain (grade ≥2) was noted in the treatment of six (54.5%) tumors, and the number of patients experiencing fever, emesis, and nerve injury were five (45.5%), two (18.2%), and one (9.0%), respectively.…”

“…In general, thermal ablation has been adapted for application in lower‐volume tumors . Increasingly, studies have demonstrated the efficacy of MWA in larger tumors . In our opinion, when MWA was performed in patients with rRPLs, boundary residue was often inevitable due to tumor size and the close proximity of vital organs.…”

Harms and benefits of adoptive immunotherapy for postoperative hepatocellular carcinoma: an updated review

“…However, 5-year disease-free survival (DFS) associated with these treatments is only about 37% [ 3 , 4 ]. Guidelines recommend transarterial chemoembolization (TACE) for intermediate or advanced HCC [ 1 , 2 ], but progression-free survival (PFS) is also unsatisfactory [ 5 , 6 ]: even after more aggressive hepatic resection, the 5-year recurrence rate can be as high as 74% [ 7 , 8 ]. These data indicate that even after curative surgery, patients with HCC have poor prognosis, highlighting the need for effective adjuvant therapies that improve patient outcomes.…”

Contrast-enhanced ultrasound with sulphur-hexafluoride in diagnosis of early HCC in cirrhosis

“…La 1) Esistono evidenze che i trattamenti locoregionali combinati (TACE + ablazione percutanea) aumentino la risposta tumorale alla terapia, ampliando il volume di necrosi tumorale ottenibile (284)(285)(286)(287)(288)(289)(290). Secondo una recente revisione sistematica della letteratura con meta-analisi (290) che ha incluso 7 studi randomizzati, la combinazione di TACE e ablazione percutanea appare più efficacedell'ablazione isolata sia in termini di tasso di recidiva sia di sopravvivenza.…”