Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis

Abstract

Abstract. Adenomyosis is a pathological gynaecological condition characterized by benign invasion of the endometrium into the myometrium. High intensity focused ultrasound (HIFU) is one of the most common therapeutic strategies for the treatment of adenomyosis. However, the efficacy of single HIFU therapy is insufficient for the treatment of patients with adenomyosis. In the present study, the efficacy of HIFU and metformin for the treatment of adenomyosis was analyzed in 274 patients with adenomyosis who were admitted to Jinan Maternity and Child Care Hospital. The results demonstrated that there was a significant reduction in menstrual flow and pain between patients who received HIFU and metformin, and those who received single HIFU treatment (P<0.01). Furthermore, the outcomes demonstrated that inflammatory cytokines levels were significantly lower compared with the baseline values (P<0.01). In conclusion, the outcomes of the current study indicate that combined HIFU and metformin treatment is more efficacious in patients with enlarged adenomyosis compared with single HIFU treatment.

Focused Ultrasound Treatment of a Spheroid In Vitro Tumour Model

“…This ATP detection assay is currently the most sensitive and has minimal interferences [24]. While FUS treatment induced a significant reduction of viable cells in both tumour spheroids over time with plate reader estimation, specialised techniques of spatial-temporal quantification [25] might bring more relevant data. The significant reduction of the spheroid area in U87 spheroids is congruent with the significant loss in cellular ATP metabolism showing the collapse of U87 cells.…”

High-intensity focused ultrasound (HIFU) combined with gonadotropin-releasing hormone analogs (GnRHa) and levonorgestrel-releasing intrauterine system (LNG-IUS) for adenomyosis: a case series with long-term follow up

“…The previous study indicated that combined HIFU and metformin treatment have a superior effect in patients with enlarged adenomyosis compared with single HIFU treatment, even though HIFU monotherapy could significantly reduce menstrual flow and pain [47]. Another report by Guo Y et al [44] revealed that combination therapy of GnRHa and HIFU could also improve the short-term clinical efficacy of HIFU ablation.…”

Influences of screening magnetic resonance imaging parameters on high-intensity focused ultrasound outcome for adenomyosis

“…The findings demonstrated that follow-up inflammatory cytokine concentration (interleukin-1, 6, and 8), cancer antigen 125, menstrual volume, and pain of HIFU plus metformin group were significantly better than those of single HIFU group, suggesting that combined HIFU and metformin treatment is more efficient than single HIFU ablation. 23…”