Combination Studies of <i>Eucalyptus torelliana</i> F. Muell. Leaf Extracts and Clarithromycin on <i>Helicobacter pylori</i>

Lawal, Temitope O.; Adeniyi, Bolanle A.; Moody, J. O.; Mahady, Gail B.

doi:10.1002/ptr.3719

Cited by 8 publications

(5 citation statements)

References 20 publications

(29 reference statements)

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“…These studies well supported the application of some of essential oils of eucalyptuses for antibacterial [1][2][3] , antifungal 4-12 , antioxidant 13,14 , cytotoxic 15 and medical treatment [16][17][18][19][20][21] . These studies well supported the application of some of essential oils of eucalyptuses for antibacterial [1][2][3] , antifungal 4-12 , antioxidant 13,14 , cytotoxic 15 and medical treatment [16][17][18][19][20][21] .…”

Section: Introductionmentioning

confidence: 61%

The Chemical Composition andin vitroAntifungal Activities of Essential Oils of FiveEucalyptusSpecies

Nikbakht

Rahimi‐Nasrabadi

Ahmadi

et al. 2015

Journal of Essential Oil Bearing Plants

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This study was designed to examine the chemical composition of essential oils of three Eucalyptus spices (E. spathulata, E. microtheca, and E. torquata) and in vitro antifungal activities of the essential oils of five Eucalyptus spices (E. largiflorens, E. oleosa, E. spathulata, E. microtheca, and E. torquata). The chemical composition of the hydrodistilled essential oils of leaves of these three spices were analyzed by GC-MS and GC-FID. The predominant and common components in the all oils were α-pinene (2.3 -14.5 %), 1,8cineole (6.6 -69.6 %), terpinen-4-ol (0.8 -9.6 %), α-terpineol (1.1 -4.3 %), aromadenderene (0.3 -10.5 %) and viridiflorol (0.0 -5.7 %). The antifungal activities of essential oils have been investigated by minimum inhibitory concentration (MIC) and disc diffusion methods against A. flavus, A. parasiticus, A. niger, P. chryzogenum and P. citrinum. A high antifungal activity was found in the leaf oil of E. largiflorens. The relationship between the some major constituents and the antifungal activity was also discussed. We concluded that the terpinen-4-ol may be considered as correspond antifungal constituent.

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Section: Introductionmentioning

confidence: 61%

The Chemical Composition andin vitroAntifungal Activities of Essential Oils of FiveEucalyptusSpecies

Nikbakht

Rahimi‐Nasrabadi

Ahmadi

et al. 2015

Journal of Essential Oil Bearing Plants

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“…In vitro anti-H. pylori activity was observed when the Terminalia macroptera root was used and also for Eucalyptus tolleria leaf extract (when used with clarithromycin) [53,54]. Interestingly, in drug-resistant strains, Combretum molle and Sclerocarya birrea were shown to be potentially effective in vitro [55,56]. The sap of the lacquer tree (Rhus verniciflua Stokes) was illustrated to have anti-H. pylori activity in a mouse model [57].…”

Section: Adjuvant Therapymentioning

confidence: 99%

Treatment of Helicobacter pylori infection 2012

et al. 2012

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Helicobacter pylori resistance rates to antibiotics vary in different countries and even in different regions of the same country. Choice of treatment is strongly dependent on antibiotic resistance rates. In some countries, triple therapy with a proton-pump inhibitor, amoxicillin, and clarithromycin is still the best option, but eradication results fall short of what would be desired (90-95%) in countries with clarithromycin resistance >20%, bismuth-containing quadruple therapy, or nonbismuth sequential or concomitant therapies may then be the preferred option. Newer antibiotic regimens are awaited. Vaccination would be the best option, especially for developing countries, but little progress has been made in designing a vaccine.A considerable amount of work has been conducted over the last year assessing many issues around Helicobacter pylori eradication therapy. These focussed primarily on assessing the efficacy of current standard triple therapy and exploring new first-line treatments. There was also progress in investigating antibiotic resistance rates, and the rescue therapies required to deal with ensuing treatment failures. There has also been an evolution in the use of adjunctive therapies. This article will address the published literature over the last year pertaining to these topics. Triple TherapyNumerous studies over the last year have assessed the efficacy of standard triple therapy with amoxicillin, clarithromycin, and a proton-pump inhibitor for the eradication of H. pylori, which have been perceived to be in decline in recent years. One such study looked at cure rates reported in all published literature from Spain between 1997 and 2008 and found that while cure rates have in fact been stable over that period, they remain inadequate with a mean cure rate of 80% by intention-to-treat and 83% by per-protocol [1]. Similar results were obtained from a multicenter study in Japan that revealed an eradication rate of 80.7% with an incidence of adverse drug reactions of 4.4% [2]. Other studies have looked at whether the efficacy of triple therapy can be improved by prolonging the course of therapy. In China, a study of shorter regimens showed eradication rates of 76, 89, and 91% for 3-day, 5-day, and 7-day regimens, respectively [3]. Increasing efficacy by prolongation of therapy was also noted in Greek patients, with eradication rates of 74.5% for 7 days, 80.6% for 10 days, and 90.2% for 14 days of therapy [4]. Another study showed that efficacy could be maintained when lower doses of medications were given, which reduced costs and side effects with cure rates of 77.2% for 10 mg rabeprazole, 500 mg amoxicillin, and 250 mg clarithromycin vs 78.9% for the standard 20 mg, 1 g, and 500 mg doses of these drugs [5].Regardless of the type of therapy used, study from Canada showed widespread failure to comply with test and treat in up to 10% of cases and a failure to confirm eradication in 32% [6]. This illustrates that efficacious first-line therapy will always depend on adherence to guidelines by phy...

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“…However, the precise mechanisms through which formulae function are poorly understood and, thus hampering the modernization of TCM, must be addressed using chemical fingerprinting coupled with systems biology. Recently, some researchers have made good attempts in this explanation using some approaches to identify the combinational roles of multi-component therapeutics from herb medicines (Du et al, 2013;Lawal et al, 2012;Zhou et al, 2012aZhou et al, , 2012b.…”

Section: Introductionmentioning

confidence: 99%

Potentiating Therapeutic Effects by Enhancing Synergism Based on Active Constituents from Traditional Medicine

Zhang

Sun

Wang

2013

Phytotherapy Research

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Shifting current drug discovery tide from 'finding new drugs' to 'screening natural products' may be helpful for overcoming the 'more investment, fewer drugs' challenge. Traditional Chinese medicine (TCM), relying on natural products, has been playing a very important role in health protection and disease control for thousands of years in Asia, whose therapeutic efficacy is based on the 'synergism', that is, the combinational effects to be greater than that of the individual drug. Based on syndromes and patient characteristics and guided by the theories of TCM, formulae are designed to contain a combination of various kinds of crude drugs that, when combined, generally assume that a synergism of all ingredients will bring about the maximum of therapeutic efficacy. The increasing evidence has shown that multiple active component combinations of TCM could amplify the therapeutic efficacy of each agent, representing a new trend for modern medicine. However, the precise mechanism of synergistic action remains poorly understood. The present review highlights the concept of synergy and gives some examples of synergistic effects of TCM, and provides an overview of the recent and potential developments of advancing drug discovery towards more agile development of targeted combination therapies from TCM.

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Combination Studies of Eucalyptus torelliana F. Muell. Leaf Extracts and Clarithromycin on Helicobacter pylori

Cited by 8 publications

References 20 publications

The Chemical Composition andin vitroAntifungal Activities of Essential Oils of FiveEucalyptusSpecies

The Chemical Composition andin vitroAntifungal Activities of Essential Oils of FiveEucalyptusSpecies

Treatment of Helicobacter pylori infection 2012

Potentiating Therapeutic Effects by Enhancing Synergism Based on Active Constituents from Traditional Medicine

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