2022
DOI: 10.3390/ijms23169014
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Abstract: Head and neck squamous cell carcinomas (HNSCCs) are a type of cancer originating in the mucosal epithelium of the mouth, pharynx, and larynx, the sixth most common cancer in the world. However, there is no effective treatment for HNSCCs. More than 90% of HNSCCs overexpress epidermal growth factor receptors (EGFRs). Although small molecule inhibitors and monoclonal antibodies have been developed to target EGFRs, few EGFR-targeted therapeutics are approved for clinical use. Ferroptosis is a new kind of programme… Show more

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Cited by 11 publications
(3 citation statements)
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“…3 F). Because nuclear receptor coactivator 4 (NCOA4), SLC3A2, GPX4, ACSL3, and FTH1 were previously established to control ferroptosis in tumor cells [ [40] , [41] , [42] , [43] ], we focused on the role of IGF2BP3 in ferroptosis in the current study.
Fig.
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Section: Resultsmentioning
confidence: 99%
“…3 F). Because nuclear receptor coactivator 4 (NCOA4), SLC3A2, GPX4, ACSL3, and FTH1 were previously established to control ferroptosis in tumor cells [ [40] , [41] , [42] , [43] ], we focused on the role of IGF2BP3 in ferroptosis in the current study.
Fig.
…”
Section: Resultsmentioning
confidence: 99%
“…In addition, RSL3 can directly act on xCT on the cell membrane surface to inhibit the cellular uptake of cystine, thereby inhibiting the synthesis of endogenous antioxidant GSH, leading to intracellular REDOX imbalance and excessive reactive oxygen species, which can damage intracellular DNA/RNA, protein and lipid biomolecules. Production of toxic oxidation products (such as lipid hydroperoxides, malondialdehyde, and 4-hydroxynonenal), in which the accumulation of phospholipid hydroperoxides, the oxidation product of unsaturated fatty acids in the cell membrane, is considered to be a hallmark of ferroptosis [21] . RSL3 can induce ferroptosis in breast cancer, colorectal cancer, pancreatic cancer, ovarian cancer, rhabdomyosarcoma, acute lymphoblastic leukemia, lung cancer, melanoma and other tumor cells [22,23] .…”
Section: Discussionmentioning
confidence: 99%
“…Currently, there are many drugs for tumor ferroptosis, and most of them inhibit system x c − and GPX4 to promote ferroptosis [ 53 , 54 , 180 , 181 ]. The structural formula of the current chemical drugs targeting ferroptosis for lung cancer is shown in Fig.…”
Section: Drugs Targeting Ferroptosis In Lung Cancermentioning
confidence: 99%